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大黄对实热证模型大鼠肝基因表达谱的影响 被引量:5
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作者 张发艳 王世军 +1 位作者 韩冰冰 赵海军 《辽宁中医杂志》 CAS 2012年第11期2297-2300,F0003,共5页
目的:利用基因芯片技术研究寒性中药大黄对2,4-二硝基苯酚致实热证模型大鼠肝脏全基因表达谱的影响,从基因水平分析大黄作用机制。方法:SPF级Wistar大鼠24只,随机分为空白对照组、模型对照组和大黄治疗组。造模后6h取肝组织,应用RatRef... 目的:利用基因芯片技术研究寒性中药大黄对2,4-二硝基苯酚致实热证模型大鼠肝脏全基因表达谱的影响,从基因水平分析大黄作用机制。方法:SPF级Wistar大鼠24只,随机分为空白对照组、模型对照组和大黄治疗组。造模后6h取肝组织,应用RatRef-12基因芯片检测各组大鼠肝脏基因表达,筛选差异表达基因,进行基因功能分类。结果:大黄水煎液组与实热模型组比较有177条差异表达基因。其中可注释基因113条,查询到29项显著性基因功能。其中生物学过程24项,主要为代谢过程功能包含59(52.21%)条差异基因;分子功能2项,主要涉及催化活性包含61(53.98%)条差异基因,其中氧化还原酶活性包含26(23%)条差异基因。结论:寒性中药大黄可调节代谢相关的基因降低机体代谢水平,实现其"清热泻火"作用。 展开更多
关键词 大黄 实热证模型 全基因表达谱系 泻火 验研究
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Validation of the TASS/SMR-S Code for the Core Heat Transfer Model on the Steady Experimental Conditions
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作者 In Sub Jun Kyoo Hwan Bae Young Jong Chung Won Jae Lee 《Journal of Energy and Power Engineering》 2012年第3期338-345,共8页
The SMART (System-integrated Modular Advanced ReacTor) which is a 330 MWt advanced integral PWR was developed by the KAERI (Korea Atomic Energy Institute) for electricity generation and seawater desalination. To e... The SMART (System-integrated Modular Advanced ReacTor) which is a 330 MWt advanced integral PWR was developed by the KAERI (Korea Atomic Energy Institute) for electricity generation and seawater desalination. To enhance its safety, the various design concepts were adopted such as the most containing of the RCS (reactor coolant system) components and a PRHRS (passive residual heat removal system). To ensure the safety and performance of the SMART, a thermal hydraulic evaluation and safety analysis are performed by the TASS/SMR-S code. It uses a one dimensional node/path modeling and point kinetics for the core power simulation. The code also has specific models reflecting the design features of the SMART such as a helical tube and PRHRS heat transfer models. In this study, the validation of the core heat transfer model in the TASS/SMR-S code on the steady conditions was performed with the Bennett's heated tube tests and THTF (thermal hydraulic test facility) experiment. From the results of the TASS/SMR-S code calculation, the CHF (critical heat flux) point and the fuel rod surface temperature were predicted conservatively compared to the test results. 展开更多
关键词 SMART TASS/SMR-S code core heat transfer model Bennett tube test THTF experiment.
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