关于“语言是形式,而不是实质(体)”的解说

在索绪尔的《普通语言学教程》中,"语言是形式,而不是实质(体)"这句话多次出现,几乎贯穿了整本书的内容,也体现了索绪尔语言学上的主要观点。反对观点认为索绪尔只注重研究语言的形式,忽视了语言的意义。笔者认为索绪尔这句话是正确的,索绪尔所说的形式并不是单纯的语言的外在表现形式,实质也并非仅仅只是语言的意义。笔者将从以下三个方面来具体阐释"语言是形式,而不是实质(体)"。

Knowledge Graph Based Method for Tracing Quality of Aerospace Products

Nowadays,the internal structure of spacecraft has been increasingly complex.As its“lifeline”,cables require extensive manpower and resources for manual testing,and it is challenging to quickly and accurately locate quality problems and find solutions.To address this problem,a knowledge graph based method is employed to extract multi-source heterogeneous cable knowledge entities.The method utilizes the bidirectional encoder representations from transformers(BERT)network to embed word vectors into the input text,then extracts the contextual features of the input sequence through the bidirectional long short-term memory(BiLSTM)network,and finally inputs them into the conditional random field(CRF)network to predict entity categories.Simultaneously,by using the entities extracted by this model as the data layer,a knowledge graph based method has been constructed.Compared to other traditional extraction methods,the entity extraction method used in this study demonstrates significant improvements in metrics such as precision,recall and an F1 score.Ultimately,employing cable test data from a particular aerospace precision machining company,the study has constructed the knowledge graph based method in the field to achieve visualized queries and the traceability and localization of quality problems.

白细胞介素4在输注供体肝脏非实质细胞诱导免疫耐受中的作用

目的 探讨皮肤移植受体在输注供体肝脏非实质细胞 (NPC)诱导免疫耐受过程中 ,白细胞介素 4(IL 4)所起的作用。方法 将 2× 1 0 7个C3H/He (C3H)小鼠的肝脏非实质细胞通过尾静脉输入C57BL/ 6(B6)小鼠的体内 ,48h后B6小鼠腹腔注射环磷酰胺 2 0 0mg/kg ,1 8d后接受C3H小鼠皮片的移植 ,分别于NPC细胞输注前及输注后 7、1 8、30、60d采血监测IL 4水平的动态变化。结果 1 5只接受皮片移植的小鼠 ,其皮片存活时间显著延长 ,皮片平均存活时间 (70± 1 7.2 )d ,正常对照组其移植皮肤的平均存活时间仅 (1 0± 0 .4)d ,用Elisa法检测NPC输注后不同时期IL 4水平的动态变化发现 ,B6小鼠体内血清IL 4水平逐渐升高 ,在长期耐受的小鼠中 ,其水平增加尤其显著 ,甚至成倍的提高。结论 IL

Conscious Entities in Superluminal Parallel Universe

Tachyons are theoretical superluminal particles, i.e., faster than light particles. The idea of existence of tachyons comes from Arnold Sommerfeld. Bilaniuk and Sudarshan （1969） published the article ＂Particles beyond the Light Barrier＂ in Physics Today magazine where they analyze the theoretical properties of tachyons. From the tachyon idea I have hypothesized the existence of a Superluminal Parallel Universe constituted by Superluminal Conscious Entities that, like the theoretical tachyons, only can exist at speeds greater than the speed of light. This hypothesis should be subject to scientific inquiry but also to philosophical speculation or spiritual imagination. Later I imagine that the Superluminal Parallel Universe is the Spiritual World thought by theologians and idealistic philosophers. I relate the Superluminal Conscious Entities with Spirits and the Superluminal Parallel Universe comprising infinity of Superluminal Conscious Entities with God, the Universal Spirit, thus being simultaneously Unity and Infinity given that superluminal speed implies non-local, instantaneous connections. I imagine that the material Universe might have emerged from that God, assuming that many Spirits could lose superluminality generating the two classes of substances of the Universe： the class of subluminal particles of matter and the class of luminal particles, like photons. I imagine a Soul as a quasi superluminal entity dropped from a Spirit to animate material entities. The substances of both Universes would have evolved in parallel, with life arising and evolving from the subluminal substance driven by companion Souls. Let＇s also imagine that the natural way of being of Spirits and free Souls is a state similar to conscious dreaming. In this imagination, we all, Souls, would have been a part of God and we all might be again. We all are makers of the Universe. We all might get connected with the Spirits in God to beg for and to receive inspiration.

Mass Transfer Enhancement of Gas Absorption by Adding the Dispersed Organic Phases

Mass transfer enhancement of gas absorption by adding a dispersed organic phase has been studied in this work. Various dispersed organic phases （heptanol, octanol, isoamyl alcohol, heptane, octane, and isooctane） were tested respectively in the experiment. According to the theoretical model and experimental data, the overall volumetric mass transfer coefficient and enhancement factor were obtained under different dispersed organic phase volume fraction and stirring speed. The experimental results indicate that gas-liquid mass transfer is enhanced at different level by adding a dispersed organic phase. The best performance of enhancement were achieved with the dispersed organic phase volumetric fraction of 5% and under an intermediate stirring speed of 670 r·min^-1. Among the organic phases tested in the experiment, alcohols show better performance, which gave 20% higher enhance-ment of overall volumetric mass transfer coefficient than adding alkanes.

Possible mechanism for hepatitis B virus X gene to induce apoptosis of hepatocytes

AIM： To investigate the possible mechanism for HBV X gene to induce apoptosis of hepatocyte HL-7702 cells.METHODS： HBV X gene eukaryon expression vector pcDNA3-X was established and transfected into HL-7702 cells by lipid-mediated transfection, including transient and stable transfection. Positive clones were screened by incubating in the selective medium with 600 μg/mL G418 and named HL-7702/HBV-encoded X protein （HBx） cells. The expressions of Fas/FasL, Bax/Bcl-2, and c-myc mRNA were measured by semi-quantitative RT-PCR in HL-7702/HBx and control group, respectively.RESULTS： RT-PCR analysis confirmed that HBV X gene was transfected into HL-7702 cells successfully. By semiquantitative RT-PCR analysis, Bax and c-myc mRNA levels in HL-7702/HBx cells of transient transfection were significantly higher than those in control, FasL and c-myc mRNA levels in HL-7702/HBx cells of stable transfection were significantly higher than those in control, whereas the Bcl-2 mRNA levels in HL-7702/HBx cells of transient and stable transfection were significantly lower than thosein control.CONCLUSION： HBV X gene may promote the apoptosis of hepatocytes by regulating the expressions of Fas/FasL, Bax/Bcl-2, and c-myc gene in a dose-dependent manner.

Systemic delivery of full-length C/EBPβ / liposome complex suppresses growth of human colon cancer in nude mice

C/EBPβ (CCAAT/enhancer-binding protein β) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBPβ protein results in cellular growth arrest and apoptosis. Using a nonviral liposome as carrier, we delivered the full-length C/EBPβ expression plasmid, pCN, into nude mice bearing CW-2 human colon cancer tumors via tail vein. Southern blots revealed that the major organs and tumors were transfected. Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN- treated mice, and such suppression was due to the overexpression of C/EBPβ, leading to the increased apoptosis in tumors of pCN-treated mice. No apparent toxic effects of pCN/liposome complex were observed in the animals. Thus, C/EBPβ has tumor suppression effect in vivo and may be used in gene therapy for cancers.

Imaging protein crystal growth behaviour in batch cooling crystallisation

The temporal and spatial growth behaviour of protein crystals, subject to different cooling strategies in protein crystallisation was investigated. Although the impact of temperature and cooling rate on crystal growth of small molecules was well documented, much less has been reported on their impact on the crystallisation of proteins. In this paper, an experimental set-up is configured to carry out such a study which involves an automatic temperature controlled hot-stage crystalliser fitted with a real-time imaging system. Linbro parallel crystallisation experiments(24-well plate) were also conducted to find the suitable initial conditions to be used in the hot-stage crystallisation experiments, including the initial concentration of HEW lysozyme solutions, precipitate concentration and pH value. It was observed that fast cooling rates at the early stage led to precipitates while slow cooling rates produced crystal nuclei, and very slow cooling rates, much smaller than for small molecules are critical to the growth of the nuclei and the crystals to a desired shape. The interesting results provide valuable insight as well as experimental proof of the feasibility and effectiveness of cooling as a means for achieving controlled protein crystallisation, compared with the evaporation approach which was widely used to grow single large crystals for X-ray diffraction study. Since cooling rate control can be easily achieved and has good repeatability, it suggests that large-scale production of protein crystals can be effectively achieved by manipulating cooling rates.

Gas–Liquid Mass Transfer Characteristics in a Gas–Liquid–Solid Bubble Column under Elevated Pressure and Temperature

abstract The volumetric mass transfer coefficient kLa of gases （H2, CO, CO2） and mass transfer coefficient kL on liquid par-affin side were studied using the dynamic absorption method in slurry bubble column reactors under elevated temperature and elevated pressure. Meanwhile, gas-holdup and gas-liquid interfacial area a were obtained. The effects of temperature, pressure, superficial gas velocity and solid concentration on the mass transfer coeffi-cient were discussed. Experimental results show that the gas-liquid volumetric mass transfer coefficient kLa and interfacial area a increased with the increase of pressure, temperature, and superficial gas velocity, and decreased with the slurry concentration. The mass transfer coefficient kL increased with increasing superficial gas velocity and temperature and decreased with higher slurry concentration, while it changed slightly with pressure. Ac-cording to analysis of experimental data, an empirical correlation is obtained to calculate the values of kLa for H2 （CO, CO2） in the gas-paraffin-quartz system in a bubble column under elevated temperature and elevated pressure.

Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats

AIM: To study the protective effect of eukaryotic expression plasmid encoding augmenter of liver regeneration (ALR) on acute hepatic injury and hepatic failure in rats. METHODS: The PCR-amplified ALR gene was recombined with pcDNA3 plasmid, and used to treat rats with acute hepatic injury. The rats with acute hepatic injury induced by intraperitoneal injection of 2 mL/kg 50% carbon tetrachloride (CCl4) were randomly divided into saline control group and recombinant pcDNA3-ALR plasmid treatment groups. Recombinant pcDNA3-ALR plasmid DNA (50 or 200 μg/kg) was injected into the rats with acute hepatic injury intravenously, intraperitoneally, or intravenously and intraperitoneally in combination 4 h after CCl4 administration, respectively. The recombinant plasmid was injected once per 12 h into all treatment groups four times, and the rats were decapitated 12 h after the last injection. Hepatic histopathological alterations were observed after HE staining, the expression of proliferating cell nuclear antigen (PCNA) in liver tissue was detected by immunohistochemical staining, and the level of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was determined by biochemical method. The recombinant plasmid DNA (200 μg/kg) and saline were intraperitoneally injected into the rats with acute hepatic failure induced by intraperitoneal injection of 4 mL/kg 50% CCl4 after 4 h of CCl4 administration, respectively. Rats living over 96 h were considered as survivals.RESULTS: The sequence of ALR cDNA of recombinant pcDNA3-ALR plasmid was accordant with the reported sequence of rat ALR cDNA. After the rats with acute hepatic injury were treated with recombinant pcDNA3-ALR plasmid, the degree of liver histopathological injury markedly decreased. The pathologic liver tissues, in which hepatic degeneration and necrosis of a small amount of hepatocytes and a large amount of infiltrating inflammatory cells were observed, and they became basically normal in the most effective group after four times of injection of recombinant pcDNA3-ALR plasmid. The indexes of PCNA significantly increased in the recombinant pcDNA3-ALR plasmid treatment groups compared to model group. The level of serum AST and ALT remarkably reduced in recombinant pcDNA3-ALR plasmid treatment groups compared to model group. The results showed that the effect of 200 μg/kg recombinant pcDNA3-ALR plasmid in the rats with acute liver injury was stronger than that of 50μg/kg pcDNA3-ALR DNA.The effect of intravenous injection of recombinant pcDNA3ALR plasmid was better. After the rats with acute hepatic failure were treated with recombinant pcDNA3-ALR plasmid,the survival rate (40%) significantly increased in treatment groups compared to control group (15%, P＜0.01).CONCLUSION: The ALR gene may play an important role in relieving acute hepatic injury and hepatic failure by promoting hepatic cell proliferation and reducing level ofAST and ALT in CCl4-intoxicated rats.

Vapor Pressure Measurement and Correlation of 2-Methyl-Butanol Acetate Containing Calcium Chloride

The CaCl2 solubility in 2-methyl-butanol acetate and the vapor pressure of 2-methyl-butanol acetate containing CaCl2 were measured in the range of 90-135°C and from very low salt concentration to saturation.The experimental data were correlated with two equations,a modified Antoine equation with the dissolved salt taken into account and a nonrandom two liquid-electrolyte（e-NRTL）model.Both models are in good agreement with the experimental data.This study provides essential physical data for further investigation of vapor-liquid equilibrium system containing salt.

Laboratory Research on Tahe AR Fluid Coking on Weak Acid Catalysts

Fluid coking on micro-spherical particles with acid sites on them could produce more light oils from Tahe AR.The conversion rate could increase by about 20% on the catalyst B compared to that obtained on the catalyst A and the light oil yield could increase by about 12%.The yield of gasoline and diesel was more than 50% from Tahe AR over the catalyst B.Tests on acidity of the catalyst B by pyridine FT-IR spectrometry showed that the total acid content and the ratio of weak acid number to total acid number were higher than other catalysts.

Application of Functional Training in College Volleyball Teaching

Volleyball Teaching in Colleges and universities is faced with multiple challenges, such as the teaching content is simple, the training method is single, the students’ physical quality is poor, the physical condition of the physical condition is the guarantee of volleyball technology. This research is on body function training on volleyball teaching methods of this technology in the project, the function of training system into the volleyball technique teaching, through the method of experimental teaching method to verify the function of training to the technical level of the student volleyball has been effectively improved.

日语的形式体言和形式名词

在日语语法中,我们经常可以见到“形式体言”或者“形式名词”这两个语法术语。应该说,这是概念完全不同的两个语法术语。但是,长期以来,在我国传统的日语语法体系中,却有很多人将二者混同起来了。这实在是一种不应该发生的误会。因此,笔者觉得重申“形式体言”和“形式名词”的不同,消除不应有的误会,不无必要。

Applying Theoretical-Methodological Tools for the Implementation of ISO 9001： 2015 Clause 4 Context of the Organization

Nowadays, in order to satisfy the ISO 9001： 2015 requirements, organizations access to information from web sites, consultant guides, Internet forums, books, and courses, as a first approximation, however, the quality, reliability, validity, and accuracy of the information content in these is limited. The research topic of this study is the use of theoretical methodological tools, whose implementation supports the organizations in the fulfillment of requirement 4 of ISO 9001：2015, adapting it to their particular needs, minimizing rework in the documentation, increasing the motivation of the personnel involved and promoting well-being within the work environment. Some theoretical methodological tools were implemented in the case of Engineering laboratories of the Faculty of Higher Studies Arag6n, that support and complement the teaching-learning process in the theoretical-practical subjects of the curricula of the engineering bachelor＇s degrees, providing students with practical training in the use of equipment, devices, and tools, as well as extracurricular courses. In the study participated the stakeholders of laboratories. From the results, it was observed that the time for the documentation of the quality management system was reduced using the theoretical tools proposed in this study. In conclusion, this study will thus be useful as a starting point in using formal tools for the implementation of ISO 9001： 2015 standard.

The Influence of Glucose on Numerical Simulation of a Vascular Solid Tumor Growth

Glucose is the mainly nutrient substances in tumor growth,which played an important role in tumor cells' growth,proliferation and immigration.Numerical simulation will help a good understanding for the influence of glucose which affected on a vascular solid tumor growth.We present a hybrid on-Lattice Model to simulate the influence of glucose on a-vascular tumor growth.The hybrid model we developed focuses on five key variables implicated in the invasion process:tumor cells,extracellular matrix,matrix-degradative enzymes,oxygen and glucose.And about the discrete model,we consider cell evolution dynamics on cell level.Results indicate that the number of proliferation and quiescent cells is decreasing by decreasing the initial glucose concentration,consequently increase necrotic area relatively.Thus there is inhabitation effect on tumor growth by decreasing initial glucose concentration.

Determination of Bed Void Fraction from Fixed Bed Breakthrough Curve

Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as ＂apparent＂ bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.

An overview of the thermography-based experimental studies on roadway excavation in stratified rock masses at CUMTB

This paper presents an overview of experimental investigations conducted at China University of Mining and Technology Beijing(CUMTB) on roadway excavation using large-scale geomechanical model tests.The simulated sedimentary rocks are composed by alternating layers of sandstone, mudstone and coal seam inclined at varied angles with respect to the horizontal including 0°, 45°, 60°, and 90°. During the excavation, infrared thermography was employed to detect the thermal response of the surrounding rocks under excavation. The obtained raw thermograms were processed using denoising algorithm, data reduction procedure and Fourier analysis. The infrared temperature(IRT) characterizes the overall rock response; the processed thermal images represent the structural behavior, and the Fourier spectrum describes damage development in the frequency domain. Deeper understanding was achieved by the comparative analyses of excavation in differently inclined rock masses using the image features of IRTs, thermal images and Fourier spectra.

Animal Experiment Study on Antitumor Effect of Matrine Liposome

Objective： To study the antitumor effect of matrine liposome in mice. Methods： The mice were selected as the research object, and SPSS （statistic package for social science）, matrine and matrine liposome were used for grouping. The antitumor effects of EAC, S 180 and H22 were evaluated by tumor weight, thymus weight and spleen weight. Results： The inhibitory effect of matrine liposome on EAC, S180 and H22 in mice was significantly higher than matrine, P 〈 0.05, which had statistical significance. Conclusion： Matrine liposome can effectively enhance the anti-tumor effect and improve the immunity of animals, which is worthy of clinical promotion.

Development and Test of an Experimental Apparatus to Study Thermal-Choking in Ideal Gases and Self-decomposition in Superheated N2O

N2O represents a popular oxidizer for hybrid rocket motors for a variety of reasons, including safety, ease of access and self-pressurization. It is often used as a saturated two-phase fluid in these applications to take advantage of self-pressurization. Recent interest in using this oxidizer in regeneratively cooled engines requires a detailed heat transfer process analysis to the coolant, in order to quantify performance. Since the injection of N2O typically takes place in the two-phase region, our study focuses on heat transfer rates in this region, and extends the region to include superheated vapor. This analysis is critical for these cooling applications, because the exothermic decomposition nature of N2O also means that unchecked heating in the superheated region may result in a runaway reaction in the cooling passages. Furthermore, provided that sufficient heat transfer rates are available, N2O is expected to accelerate in the cooling passages due to Rayleigh flow effects much like those of a calorically perfect gas. The proximity of superheated N2O to its saturated vapor curve, at the conditions studied here, makes the suitability of a perfect gas model questionable, but that benchmarks is still useful. This paper presents the development of an experimental apparatus （a ＂Rayleigh tube＂）, specifically designed to study this problem, and test the analytical methods developed to model it. Since we focus on the development of the apparatus, the data presented were uses primarily calorically perfect gas surrogates, but the goal is to apply the apparatus and method to N2O. The design and construction of the Rayleigh tube is presented, along with preliminary results with perfect gases. Finally, we present preliminary results on heated N2O flow. Using a simple model for predicted dry-out point, we investigate where superheating may be expected to occur. We present estimates of critical heating and compare them to the heat required to achieve self-decomposition.