One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present...One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.展开更多
Based on the viewpoint that there are similarities to the genetic principles in the mechanics and the engineering fields; based on data in some referents and author＇s theoretical approach, this paper is to consider t...Based on the viewpoint that there are similarities to the genetic principles in the mechanics and the engineering fields; based on data in some referents and author＇s theoretical approach, this paper is to consider the microscopic-damage and the macroscopic-damage behaviors of materials that are distinct differences, thereby to propose computing models and methods of subsection calculations in whole process; to consider the behaviors between the short cracks and long ones both of which are always continuous, thereby to propose some computing models and methods of the successive calculations. These computing models refer to formulas of the threshold sizes of cracks （or threshold values of damages）; the propagating rates of cracks; the predicting calculations of lifetime; Particularly, in which it provides a best new comprehensive figure that it could be including mid describing all problems mentioned above. So it may be as a bridge to link the traditional material mechanics, the material discipline and the modem mechanics on fatigue-damage-fracture; perhaps, it can also be as route diagram to guide designs and calculations to some materials and structures. Therefore, above works realize calculations of the strength problems, the growth rate of cracks （damages） mid prediction of lifetime in whole process that would have practical significances.展开更多
文摘One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.
文摘Based on the viewpoint that there are similarities to the genetic principles in the mechanics and the engineering fields; based on data in some referents and author＇s theoretical approach, this paper is to consider the microscopic-damage and the macroscopic-damage behaviors of materials that are distinct differences, thereby to propose computing models and methods of subsection calculations in whole process; to consider the behaviors between the short cracks and long ones both of which are always continuous, thereby to propose some computing models and methods of the successive calculations. These computing models refer to formulas of the threshold sizes of cracks （or threshold values of damages）; the propagating rates of cracks; the predicting calculations of lifetime; Particularly, in which it provides a best new comprehensive figure that it could be including mid describing all problems mentioned above. So it may be as a bridge to link the traditional material mechanics, the material discipline and the modem mechanics on fatigue-damage-fracture; perhaps, it can also be as route diagram to guide designs and calculations to some materials and structures. Therefore, above works realize calculations of the strength problems, the growth rate of cracks （damages） mid prediction of lifetime in whole process that would have practical significances.
