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人纤维蛋白原装量差异试验的摸索
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作者 邵逸文 孙琪英 +3 位作者 曹大伟 赵景辉 赵明芬 王彬 《中国卫生标准管理》 2021年第1期101-104,共4页
目的由于人纤维蛋白原黏度较大,对于装量差异检查方法的精准度与实验时程有一定的影响。本实验旨在《中国药典》2015年版中装量差异检查方法的基础上进行试验摸索,提高日常检验工作的效率。方法利用氢氧化钠溶液作为该药品的清洗剂,对... 目的由于人纤维蛋白原黏度较大,对于装量差异检查方法的精准度与实验时程有一定的影响。本实验旨在《中国药典》2015年版中装量差异检查方法的基础上进行试验摸索,提高日常检验工作的效率。方法利用氢氧化钠溶液作为该药品的清洗剂,对模制瓶进行清洗,实验设置0.1 mol/L、0.5 mol/L、1 mol/L、5 mol/L、10 mol/L、25 mol/L共6个浓度的氢氧化钠溶液作为清洗液对人纤维蛋白原进行清洗,后对比常规试验方法的试验时程、装量差异结果,得出结论。结果在氢氧化钠溶液浓度超过5 mol/L时,模制瓶瓶壁上无药品残留。后与常规方法相比较,对同一批药品来说,装量差异准确度提高。常规方法最大装量差异在0.03%,利用氢氧化钠清洗后的最大装量差异为0.3%,装量差异准确度提高了10倍。由于用于冲洗的时间由平均17 min减少至1.3 min,试验时程得到缩短。结论发现利用氢氧化钠作为清洗剂对人纤维蛋白原进行清洗时更加精确、省时。 展开更多
关键词 人纤维蛋白原 装量差异 蛋白质 氢氧化钠 模制瓶 实验时程
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The shortest period of coal spontaneous combustion on the basis of oxidative heat release intensity 被引量:5
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作者 Yang Yongliang Li Zenghua +3 位作者 Hou Shisong Gu Fanjun Gao Siyuan Tang Yibo 《International Journal of Mining Science and Technology》 SCIE EI 2014年第1期99-103,共5页
It’s necessary to forecast the shortest spontaneous combustion period for preventing and controlling the coal spontaneous combustion.During the experimental process,a calculating model of the SSCP is established on t... It’s necessary to forecast the shortest spontaneous combustion period for preventing and controlling the coal spontaneous combustion.During the experimental process,a calculating model of the SSCP is established on the basis of the oxidative heat release intensity and thermal capacity at different temperatures.According to the basic parameters of spontaneous combustion,heat of water evaporation and gas desorption,the SSCPs of different coals are further predicted.Finally,this study analyzed the relationships of the SSCP and the judging indexes of the self-ignite tendency.The result shows that the SSCP non-linearly increases with the decrease of dynamic oxygen adsorption and increase of activation energy.Compared with the practical fire situation of mine,this reliable method can meet the actual requirement of mine production. 展开更多
关键词 Coal spontaneous combustion The shortest period of spontaneouscom bustion Heat release intensity of coal oxidation Thermal capacity Judging indexes
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Numerical and Experimental Study on Droplet Spreading Motion after Impingement Considering Dynamic Contact Angle with CCUP (CIP-Combined Unified Procedure) Method
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作者 Soyoun Son Gwonhyun Ko Hongsun Ryou 《Journal of Energy and Power Engineering》 2013年第1期10-16,共7页
The contact angle is one of important parameters to simulate droplet spreading and impingement phenomena on the surface. In the most numerical research, it is assumed constant value and it is implemented as boundary c... The contact angle is one of important parameters to simulate droplet spreading and impingement phenomena on the surface. In the most numerical research, it is assumed constant value and it is implemented as boundary condition. However, contact angle is changed according to contact line velocity and time. Hence, for accurate simulation, dynamic contact angle which has various values as time elapsed is adopted. In the present study, the numerical analysis is performed on the droplet spreading phenomena considering dynamic contact angle function which is obtained from single droplet spreading experiment on the flat and bare surface. The CIP (cubic interpolated pseudo-particle) method by Yabe is used for analysis of interface between liquid and gas phases. The numerical results considering contact angle function which newly modeled as time and contact angle are compared with numerical results considering Hoffman's function and experimental data for range of Weber number which are 4.427 and 11.334. In contrast of numerical result considering Hoffman's function, the numerical result shows good agreement with experimental data as time elapsed in contact angle evolution, deformation of droplet spreading radius and height. Indeed, overall, the results display the increasing maximum spreading radius and the decreasing height as Weber numbers increased. 展开更多
关键词 CIP method droplet spreading height droplet spreading radius dynamic contact angle Hoffman's fimction.
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Experimental and Analytical Study of Torsional Vibration under Multiaxial Loading in Time Domain
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作者 Dionisio Jose Rodrigues da Costa Ladario da Silv +1 位作者 Jorge Rodrigues Duran Jose Flavio Feiteira 《Journal of Mechanics Engineering and Automation》 2016年第3期148-157,共10页
The torsional vibration of power transmission shaft is a phenomenon whose analytical modeling can be represented by a differential equation of motion proposed by technical literature. The solutions of these equations ... The torsional vibration of power transmission shaft is a phenomenon whose analytical modeling can be represented by a differential equation of motion proposed by technical literature. The solutions of these equations need coefficients and parameters that, usually, must be experimentally estimated. This work uses a resistive electric SG (strain gage) to dynamically determine strains produced in the shaft due to harmonic oscillatory motion under multiaxial loading. This movement is simulated on a prototype specially developed for this purpose. It comprises a pulley attached to the end of a stepped cantilevered shaft, which is clamped at the opposite end. In this configuration, a cam generates a torque to the system, springs regulate the stiffness and the damping coefficient of the assembly, as well as they can be suitably adjusted to produce an underdamped condition. The main advantage, highlighted in this study, refers to a major simplification. Although the system under study shows multiple degrees of freedom (torsion and bending), the shape and the positioning of linking SGs with the resistor bridge (Wheatstone Bridge), allow "to evaluate the loading effects independently, as if only one degree of freedom of the system exists at a time domain. Strains graphs for two forms of cyclic torsional oscillation, analytical and experimental, were successfully generated. 展开更多
关键词 Underdamped system free and forced response torsional vibration strain gauges.
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Aniline destruction by supercritical water oxidation and its reaction kinetics
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作者 WANG Jing-chang ZHAO Qi-cheng +1 位作者 LI Zhi-yi ZHANG Ping 《Journal of Environmental Science and Engineering》 2009年第7期14-17,共4页
Supercritical water oxidation (SCWO) is an effective method for wastewater treatment. In this study, a lot of experiments are carried out to study the influence of various factors on the aniline destruction rate in ... Supercritical water oxidation (SCWO) is an effective method for wastewater treatment. In this study, a lot of experiments are carried out to study the influence of various factors on the aniline destruction rate in the SCWO process with a novel experiment setup. The experimental results show that the aniline destruction rate rises with the increase of the residence time, the reaction temperature and the reaction pressure. A dynamics analysis of the aniline SCWO reaction is conducted and the dynamic equation is obtained. 展开更多
关键词 wastewater treatment supercritical water oxidation aniline destruction
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补肾方药对老年大鼠学习记忆退化的影响 被引量:4
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作者 康湘萍 金国琴 《中华中医药杂志》 CAS CSCD 北大核心 2012年第4期981-986,共6页
目的:从糖皮质激素受体-脑源性神经营养因子-NMDAR(GCR-BDNF-NMDAR)信号转导通路角度,探讨老年大鼠学习记忆退化的分子机制及补肾方药——左归丸、右归丸的调整作用。方法:以自然衰老(24月龄)SD雄性大鼠为动物模型,随机分为老年对照组... 目的:从糖皮质激素受体-脑源性神经营养因子-NMDAR(GCR-BDNF-NMDAR)信号转导通路角度,探讨老年大鼠学习记忆退化的分子机制及补肾方药——左归丸、右归丸的调整作用。方法:以自然衰老(24月龄)SD雄性大鼠为动物模型,随机分为老年对照组、老年皮质酮(GC)拮抗组、老年左归组和老年右归组,另设一组青年对照组(5月龄)。采用ELISA法检测大鼠血清皮质酮含量、Morris水迷宫法观察大鼠空间学习记忆能力、电生理方法记录在体大鼠LTP变化,Western Blot及免疫组化法观察大鼠学习记忆相关信号转导蛋白表达变化,同时观察补肾方药对上述指标变化的改善作用。结果:与青年对照组相比,老年大鼠血清皮质酮含量显著升高、空间学习记忆能力显著下降(P<0.05)、海马CA1区LTP明显受到抑制、与学习记忆相关的信号分子蛋白表达均明显降低(P<0.05),左归丸、右归丸能不同程度地改善上述指标的衰老性变化。结论:左归丸、右归丸改善老年大鼠增龄性学习记忆退化的部分机制可能与提高GCR、BDNF、NMDAR、钙/钙调素依赖性蛋白激酶Ⅱ(CaMKⅡ)、细胞外调节蛋白激酶(ERK1/2)、CAMP反应元件结合蛋白(CREB)蛋白表达,拮抗高水平皮质酮对大脑海马区域的毒性作用有关。 展开更多
关键词 老年大鼠 皮质酮 时程增强实验 学习记忆相关信号分子 左归丸 右归丸
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