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丹参注射液对消炎痛引起的大鼠胃粘膜损伤的保护作用 被引量:2
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作者 庹必光 葛正龙 +2 位作者 欧刚卫 晏永慧 赵逵 《遵义医学院学报》 1995年第1期18-20,共3页
本研究通过建立大鼠消炎痛胃粘膜损伤模型,观察丹参0.1ml/kg、0.2ml/kg、0.6ml/kg和2ml/kg以及给丹参后不同的作用时间对消炎痛引起的胃粘膜损伤的保护作用。结果表明丹参具有明显的保护胃粘膜的作用,但其保护作用不随着剂量... 本研究通过建立大鼠消炎痛胃粘膜损伤模型,观察丹参0.1ml/kg、0.2ml/kg、0.6ml/kg和2ml/kg以及给丹参后不同的作用时间对消炎痛引起的胃粘膜损伤的保护作用。结果表明丹参具有明显的保护胃粘膜的作用,但其保护作用不随着剂量的增加而增强。不同作用时间的结果表明以给丹参后1h效果较好。 展开更多
关键词 丹参 消炎痛 胃粘膜损伤 实验药理药
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Serious response during tilt-table test in elderly and its prophylactic management 被引量:2
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作者 韩阳 李晓霞 +2 位作者 蒋伟莉 王招娣 陈天秩 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2005年第4期304-306,共3页
Objective: To evaluate the serious response during tilt-table test (TTT) and its prophylactic management. Method: Seventy-six elderly patients were tested at a tilt angle of 70 degrees for a maximum of 45 min and then... Objective: To evaluate the serious response during tilt-table test (TTT) and its prophylactic management. Method: Seventy-six elderly patients were tested at a tilt angle of 70 degrees for a maximum of 45 min and then subjected to isoprotere- nol-provocative tilt testing. ECG and blood pressure were monitored during the test and patients were kept at normal saline con- dition through a peripheral intravenous duct. Results: Fifty-one of 76 patients were defined as positive including 23 having serious response; 6 of the 23 patients had arteriosclerosis involving internal carotid arteries and 7 cases had bradycardia, two of which were associated with II°-I A-V block and the others with chronic atrial fibrillation. The serious response consisted of cardiac arrest for more than 5 s (6 cases), or serious bradycardia for more than 1 min (7 cases) or serious hypotension for more than 1 min (10 cases). Those with serious response were managed by returning to supine position, thus driving up legs and intravenous atropine, CPR (2 cases with cardiac arrest) and needing oxygen supplementation (11 cases). Only 2 hypotension patients recovered gradually by 10 min after emergency management, while others recovered rapidly with no complications. Conclusion: Although non-invasive, TTT may result in serious response, especially in elderly. Therefore proper patient selection, control of isoproterenol infusion and close observation of vital signs are decisive for a safe consequence. 展开更多
关键词 Tilt-table test (TTT) Vasovagal syncope (VVS) Serious response Prophylactic management
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Inhibition of Urogenital Chlamydia Trachomatis in Vitro by 12 Diuretic Traditional Chinese Medicines
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作者 李建军 涂裕英 +1 位作者 佟菊贞 汪培士 《Chinese Journal of Sexually Transmitted Infections》 2002年第1期38-40,共3页
Objective: To detect the inhibition of urogenitalchlamydia trachomatis (CT) by 12 traditional Chinesemedicines in vitro.Methods: The inhibition of CT isolates by these medicineswas detected by micro-culture technique ... Objective: To detect the inhibition of urogenitalchlamydia trachomatis (CT) by 12 traditional Chinesemedicines in vitro.Methods: The inhibition of CT isolates by these medicineswas detected by micro-culture technique with McCoy cellsin vitro. Results: All the diuretic traditional Chinese medicinesinhibited urogenital CT The minimum inhibitoryconcentrations (MICs) ranged from 0.122 mg ml^(-1) to 62.5mg ml^(-1). Diathus superbus L., Poria cocos (Shew.) Woft,Polyporus umbellatus (Pers.) Fries, and Artemisia capillariesThunb showed stronger inhibition than the other eighttraditional Chinese medicines. The numbers and sizes ofinclusions bodies reduced gradually and disappeared finallywith the increase of the concentrations. Conclusion: All the 12 diuretic traditional Chinesemedicines inhibited urogenital CT. 展开更多
关键词 Diuretic traditional Chinese medicines chlamydia trachomatis nongonococcal urethritis drug sensitivity assay
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Preparation and quality assessment of high-purity ginseng total saponins by ion exchange resin combined with macroporous adsorption resin separation 被引量:13
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作者 ZHAO Yu-Nan WANG Zhong-Li +2 位作者 DAI Jian-Guo CHEN Lin HUANG Yu-Fang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期382-392,共11页
AIM: To prepare high-purity ginseng total saponins from a water decoction of Chinese ginseng root.METHOD: Total saponins were efficiently purified by dynamic anion-cation exchange following the removal of hydrophili... AIM: To prepare high-purity ginseng total saponins from a water decoction of Chinese ginseng root.METHOD: Total saponins were efficiently purified by dynamic anion-cation exchange following the removal of hydrophilic impurities by macroporous resin D101. For quality control, ultrahigh-performance liquid chromatography with a charged aerosol detector (CAD) was applied to quantify marker components. The total saponin content was estimated by a colorimetric method using a vanillin-vitriol system and CAD response. RESULTS: D201, which consisted of a cross-linked polystyrene matrix and -]N+(CI-13)3 functional groups, was the best of the four anion exchange resins tested. However, no significant difference in cation exchange ability was observed between D001 (strong acid) and D 113 (weak acid), although they have different functional groups and matrices. After purification in combination with D101, D201, and D 113, the estimated contents of total saponins were 107% and 90% according to the colorimetric method and CAD response, respectively. The total amount of representative ginsenosides Re, Rd, Rgl, and compound K was approximately 22% based on ultrahigh-performance liquid chromatography-CAD quantitative analysis. CONCLUSION: These findings suggest that an ion exchange resin, combined with macroporous adsorption resin separation, is a promising and feasible purification procedure for neutral natural polar components. 展开更多
关键词 Panax ginseng GINSENOSIDES Ion exchange resin Macroporous resin Quality assessment
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Ma Huang Tang ameliorates asthma though modulation of Th1/Th2 cytokines and inhibition of Th17 cells in ovalbumin-sensitized mice 被引量:11
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作者 MA Chun-Hua MA Zhan-Qiang +1 位作者 FU Qiang MA Shi-Ping 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期361-366,共6页
AIM: Ma Huang Tang (Ephedra decoction, MHT) is a famous classical formula from Shang Han Lun by Zhang Zhongjing in the Han Dynasty. The anti-asthmatic effects of MHT and the possible mechanisms were tested. METHOD... AIM: Ma Huang Tang (Ephedra decoction, MHT) is a famous classical formula from Shang Han Lun by Zhang Zhongjing in the Han Dynasty. The anti-asthmatic effects of MHT and the possible mechanisms were tested. METHOD: An asthma model was established by ovalbumin (OVA)-induction in mice. A total of forty-eight mice were randomly assigned to six experimental groups: control, model, dexamethasone (2 mg·kg^-1) and MHT (5, 10, and 20 mg·kg^-1). Airway resistance (Raw) was measured by the forced oscillation technique, histological studies were evaluated by hematoxylin and eosin (HE) staining, Thl/Th2 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay (ELISA), and Thl7 cells were evaluated by flow cytometry (FCM).RESULTS: This study demonstrated that MHT inhibited OVA-induced increases in Raw and eosinophil cotmt; interleukin (IL)-4 and IL-17 levels were recovered in bronchoalveolar lavage fluid, increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that MHT substantially inhibited OVA-induced eosinophilia in lung tissue. Flow cytometry studies demonstrated that MHT substantially inhibited Thl 7 cells.CONCLUSION: These findings suggest that MHT may effectively ameliorate the progression of asthma, and could be further investigated for potential use as a therapy for patients with allergic asthma, 展开更多
关键词 Ma Huang Tang ASTHMA THL/TH2 Thl7 cells
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Study of the anti-MRSA activity of Rhizoma coptidis by chemical fingerprinting and broth microdilution methods 被引量:6
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作者 LUO Jiao-Yang YAN Dan YANG Mei-Hua 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期393-400,共8页
AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that causes both hospital- and community-acquired infections, and for which single-drug treatments are becoming less efficient. Rhiz... AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that causes both hospital- and community-acquired infections, and for which single-drug treatments are becoming less efficient. Rhizoma coptidis has been used for more than two thousand years in China to treat diarrhea, fever, and jaundice. In this study, the anti-MRSA activity of Rhizoma coptidis is examined and its effective components sought. METHODS: The mecA and norA genes were determined by PCR amplification and sequencing. Drug susceptibility of Staphylococcus aureus ATCC43300 was performed using the VITEK2 compact system. The chemical fingerprint of Rhizoma coptidis was investigated using HPLC and preparative liquid chromatography, and the anti-MRSA activity was determined using an improved broth microdilution method. RESULTS: The drug susceptibility test revealed that the penicillin-binding protein phenotype of the strain changed in comparison to penicillin-sensitive Staphylococcus aureus. Ten batches of Rhizoma coptidis showed anti-MRSA activity on the norA-negative Staphylococcus aureus strain, as well as the strain that contained a norA gene. The spectrum-effect relationship revealed that the berberine alkaloids were the effective components, within which berberine, coptisine, palmatine, epiberberine,, and jatrorrhizine were the major components. CONCLUSION: This study lays a foundation for in vivo studies of Rhizoma eoptidis and for the development of multi-component drugs. 展开更多
关键词 MRSA Rhizoma coptidis mecA and norA gene Broth microdilution method Preparative liquid chromatography
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Modified Si-Miao-San ameliorates pancreatic B cell dysfunction by inhibition of reactive oxygen species-associated inflammation through AMP-kinase activation 被引量:5
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作者 SHANG Shu-Wan YANG Jiang-Lin +2 位作者 HUANG Fang LIU Kang LIU Bao-Lin 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期351-360,共10页
AIM: To observe the effect of modified Si-Miao-San (mSMS) on advanced glycation end products (AGEs)-induced pancreatic B cell dysfunction, as well as examining the underlying mechanisms.METHOD: Pancreatic B cel... AIM: To observe the effect of modified Si-Miao-San (mSMS) on advanced glycation end products (AGEs)-induced pancreatic B cell dysfunction, as well as examining the underlying mechanisms.METHOD: Pancreatic B cells (INS-l) were stimulated with advanced glycation end products (AGEs, 200 μg.mL^-1) for 24 h to produce dysfunction in pancreatic B cells and the effects of mSMS observed on insulin secretion, NF-κB (p65) phosphorylation, reactive oxygen species (ROS) production, mitochondria membrane potential (△ψm), cell apoptosis, phosphorylation of AMP-kinase (AMPK), and caspase 3 activity. RESULTS: The AGEs challenge resulted in increased basal insulin secretion, but decreased insulin secretion in response to high glucose, whereas this situation was reversed by mSMS treatment. AGEs stimulation induced NF-κB (p65) phosphorylation and reactive oxygen species (ROS) production, as well as Agtm collapse and cell apoptosis, mSMS inhibited ROS production and inhibited NF-κB activation by attenuating p65 phosphorylation. Meanwhile, AGEs-induced A^m collapse and cell apoptosis were also reversed by mSMS treatment. Compound C, an inhibitor of AMP-Kinase (AMPK), abolished the beneficial effects of mSMS on the regulation of B cell fimction, indicatin~ the involvement of AMPK. cONCLUSION: mSMS ameliorated AGEs-induced B cell dysfimction by suppressing ROS-associated inflammation, and this action was related to its beneficial regulation of AMPK activity. 展开更多
关键词 Modified Si-Miao-San Advanced glyeation end products Pancreatic B cells INFLAMMATION AMP-kinase
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Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity 被引量:5
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作者 Munyangaju Jose Edouard MIAO Lin +5 位作者 FAN Guan-Wei Barnabas Bessem Orang Ojong ZHEN Hu ZHANG Ju GAO Xiu-Mei ZHU Yan 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期321-334,共14页
The concept of phytoandrogens, plants that contain androgens or those that stimulate androgenic activity in men, is relatively new. In traditional Chinese medicine a number of phytoandrogens are classified in medicina... The concept of phytoandrogens, plants that contain androgens or those that stimulate androgenic activity in men, is relatively new. In traditional Chinese medicine a number of phytoandrogens are classified in medicinal plant restoratives for reinforcing yang, and they find their application in the treatment of the kidney yang deficiency diseases. In this review, the phytoandrogens used in traditional Chinese medicine are listed, and their proven applications in the treatment of kidney yang deficiency diseases, such as sexual disorders, cancer, and obesity and associated metabolic syndromes are presented. As a background, the mechanism of action of androgens, their synthesis and metabolism, the interrelations of androgens and estrogens, as well as the state of art methods to detect and analyze these hormonal activities in medicinal plants are discussed. 展开更多
关键词 Phytoandrogens Yang-tonifying traditional Chinese herbs ANDROGENS Kidney yang deficiency
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A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz 被引量:4
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作者 WANG Pei-Pei ZHAO Guo-Wei +2 位作者 XIA Wen HAN En-Ji XIANG Lan 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期377-381,共5页
This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and ... This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and their structures were elucidated on the basis of physical characteristics and spectral data. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity and acetylcholinesterase (AChE)-inhibitory activity of the compounds were evaluated. Five compounds were obtained and identified as 8-C-β-D-glucopyranosylkaempferol-3-O-β-D-glucopyranoside (1), 1, 2-dihydro-6,8-dimethoxy-7-hydroxy-l-(3, 5-dimethoxy-4-hydroxyphenyl)-N^1, N^2-bis-[2-(4-hydroxyphenyl)ethyl]-2, 3-naphthalene dicarboxamide (2), goniothalactam (3), aristololactam A IIla (4) and piperlonguminine (5). Compound 1 was a new flavonol C-glycoside, 2 was a rare lignanamide, which was isolated from the family Piperaceae for the first time, and compound 3 was isolated from this plant for the first time. Among them, 2 showed potent DPPH-scavenging activity, with IC50 of 31.38 ± 0.97 μmol·L^-1; Compounds 2, 3, and 4 showed AChE inhibitory activity at 100 μmol·L^-1, with inhibition rates of 28.57% ± 1.47%, 18.48% ± 2.41% and 17.4% ±3.03%, respectively. 展开更多
关键词 Piper wallichii Flavonol C-glycoside Lignanamide DPPH scavenging activity AChE inhibitory activity
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Effects of feeding tyrosine and phenylalanine on the accumulation of phenylethanoid glycosides to Cistanche deserticola cell suspension culture 被引量:2
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作者 HU Gao-Sheng JIA Jing-Ming Doh Hoon Kim 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期367-372,共6页
AIM: To investigate the effects of feeding phenylalanine(Phe) and tyrosine(Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides(PeGs) to a cell suspension culture of the parasitic pl... AIM: To investigate the effects of feeding phenylalanine(Phe) and tyrosine(Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides(PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD: A cell suspension culture of C. deserticola was established and precursors of different concentrations were fed. In each group, the cell was sampled at the 24th day after inoculation. The content of total phenolic compounds and four PeGs compounds were determined using the Folin-Ciocalteu method and an HPLC method, respectively. RESULTS: In the Phe fed cells, the maximum PeGs yield was achieved when Phe was fed at 1.5 mmol·L-1 and the yield reached 1.13 times the control cell concentration. In the Tyr fed cells, the maximum yield of PeGs was 1.60 times of control when 0.75 mmol·L-1 Tyr was fed to the cells. Furthermore, it was found that the salidroside yield was 4.01 times of control group when 5 mmol·L-1 Tyr was fed. CONCLUSION: Tyr is a better precursor for PeGs accumulation compared with Phe, and the rate limiting enzymes might be involved in the Tyr branch. 展开更多
关键词 Cistanche deserticola Cell suspension culture PHENYLALANINE TYROSINE Precursor feeding RP-HPLC SALIDROSIDE BIOSYNTHESIS Phenylethanoid glycosides
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Indigenous plant medicines for health care:treatment of Diabetes mellitus and hyperlipidemia 被引量:2
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作者 Nisha H. Parikh Palak K. Parikh Charmy Kothari 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期335-344,共10页
Medicinal plants have played an important role in treating and preventing a variety of diseases throughout the world. Metabolic syndrome had become a global epidemic, defined as a cluster of three of five criteria: i... Medicinal plants have played an important role in treating and preventing a variety of diseases throughout the world. Metabolic syndrome had become a global epidemic, defined as a cluster of three of five criteria: insulin resistance and glucose intolerance, abdominal obesity, hypertension, low high-density cholesterol, and hypertriglyeeridemia. The current review fo- cuses on Indian medicinal plant drugs and plants used in the treatment of diabetes and hyperlipidemia. Though there are various approaches to reduce the ill-effects of diabetes and hyperlipidemia and its secondary complications, plant-based drugs are preferred due to lesser side effects and low cost. The current review focuses on twenty-three medicinal plants used in the treatment of Diabe- tes mellitus and nine medicinal plants used in the treatment of hyperlipidemia. The wealth of knowledge on medicinal plants points to a great potential for research and the discovery of new drugs to fight diseases, including diabetes and hyperlipidemia. 展开更多
关键词 Diabetes mellitus HYPERLIPIDEMIA Medicinal plants TREATMENT
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A new Lycopodium alkaloid from Phlegmariurus fargesii 被引量:2
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作者 PAN Ke LUO Jian-Guang KONG Ling-Yi 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期373-376,共4页
AIM: To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii. METHOD: Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectros... AIM: To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii. METHOD: Compounds were isolated by repeated silica gel column chromatography. Their structures were elucidated by spectroscopic methods and chemical correlation. The acetylcholinesterase(AChE) inhibitory activity of the isolated compounds was evaluated. RESULTS: A new Lycopodium alkaloid, lycopodine N-oxide(1), along with lycopodine(2), 8,15-dehydrolycopodine(3), 6α-hydroxylycopodine(4), deacetyllycoclavine(5), N-methylhuperzine B(6), lycodine(7), and phlegmarine(8), was isolated. CONCLUSION: Compound 1 is a new Lycopodium alkaloid, and compound 3 was obtained from nature for the first time. Other alkaloids are isolated from this plant for the first time. 展开更多
关键词 Phlegmariurusfargesii Lycopodium alkaloids Lycopodine N-oxide
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Cardioprotective and antioxidant effects of oleogum resin "Olibanum" from Boswellia carteri Birdw.(Bursearceae) 被引量:1
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作者 Ahmed A. Zaki Nadia E. Hashish +1 位作者 Mohamed A. Amer Mohamed-Farid Lahloub 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第5期345-350,共6页
One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or fran... One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or frankincense, is considered to possess diverse medicinal values in traditional medicine and from recent biological studies. Investigating the cardioprotective and antioxidant activities of olibanum from a Bo~'wellia species, family Bursearaceae, namely Boswellia carteri Birdw. was the aim of this study. Cardioprotective activity was evaluated using a model of myocardial infarction induced by isoprenaline (ISO), while antioxidant activity was tested adopting nitric oxide scavenging (NOS) and azino-bis-3-ethyl benzthiazoline-6-sulfonic acid (ABTS) assays. The results revealed a mild cardioprotecfive effect and weak antioxidant activity. 展开更多
关键词 Boswellia carteri OLIBANUM Frankincense Cardiovascular diseases ANTIOXIDANT
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