AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk. METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies...AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk. METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 casecontrol studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.RESULTS: The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity). CONCLUSION: Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.展开更多
This article explores, through a case study, measures of energy efficiency in data processing centers. An analysis of this case demonstrates how the design criteria could improve the rate of consumption in IT centers,...This article explores, through a case study, measures of energy efficiency in data processing centers. An analysis of this case demonstrates how the design criteria could improve the rate of consumption in IT centers, which is currently the second most contaminating industry on the planet, and is the responsible for 2% of CO2 emissions, surpassed only by the aeronautical industry. The present and future situation of IT center energy consumption and associated environmental effects is analyzed, and also looks at how state-of-the-art technology, correctly implemented, could ensure significant rationalization of data processing center energy consumption. The article will examine optimization techniques, specific problems and case studies.展开更多
文摘AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk. METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 casecontrol studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.RESULTS: The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity). CONCLUSION: Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.
文摘This article explores, through a case study, measures of energy efficiency in data processing centers. An analysis of this case demonstrates how the design criteria could improve the rate of consumption in IT centers, which is currently the second most contaminating industry on the planet, and is the responsible for 2% of CO2 emissions, surpassed only by the aeronautical industry. The present and future situation of IT center energy consumption and associated environmental effects is analyzed, and also looks at how state-of-the-art technology, correctly implemented, could ensure significant rationalization of data processing center energy consumption. The article will examine optimization techniques, specific problems and case studies.
