There is a strange disease called proctalgia fugax in which rather uncomfortable pain appears suddenly mostly at night without any particular warning and disappears completely without any objective traces. It also is ...There is a strange disease called proctalgia fugax in which rather uncomfortable pain appears suddenly mostly at night without any particular warning and disappears completely without any objective traces. It also is categorized as a functional anorectal pain under the Rome II (diagnostic criteria for the functional gastrointestinal disorders). For the causes, many theories have been advocated but not decisive and therefore were not linked to the definite treatment. The author experienced 68 patients with proctalgia fugax, among which 55 patients had tenderness along the pudendal nerve. The location, character, and degree of pain caused by digital examination were confirmed by all of them to be similar to that which they experience at times of paroxysm. After administration of a nerve block, symptoms disappeared completely in 65 percent of the patients and decreased in 25 percent. These data suggest that the pathogenesis of proctalgia fugax is neuralgia of the pudendal nerves.展开更多
Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We eval...Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.展开更多
Purpose: We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the tre...Purpose: We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients. Methods: Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Bromfenac eye drops and the contralateral eye was treated with Pemirolast eye drops for 1 week. Subjective ocular symptoms and objective ocular signs evaluated by slit-lamp examination were scored and recorded before and after treatment. Results: Both drugs significantly decreased ocular signs after 1 week, but not symptoms. No significant differences in subjective symptoms or objective signs were observed between the two drugs. Ten patients (45.5% ) selected Bromfenac as more effective, nine patients (40.9% ) selected Pemirolast, and three patients found no difference in efficacy between the two drugs. Conclusion: Bromfenac sodium is as safe and effective for the treatment of allergic conjunctivitis as pemirolast potassium.展开更多
文摘There is a strange disease called proctalgia fugax in which rather uncomfortable pain appears suddenly mostly at night without any particular warning and disappears completely without any objective traces. It also is categorized as a functional anorectal pain under the Rome II (diagnostic criteria for the functional gastrointestinal disorders). For the causes, many theories have been advocated but not decisive and therefore were not linked to the definite treatment. The author experienced 68 patients with proctalgia fugax, among which 55 patients had tenderness along the pudendal nerve. The location, character, and degree of pain caused by digital examination were confirmed by all of them to be similar to that which they experience at times of paroxysm. After administration of a nerve block, symptoms disappeared completely in 65 percent of the patients and decreased in 25 percent. These data suggest that the pathogenesis of proctalgia fugax is neuralgia of the pudendal nerves.
文摘Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.
文摘Purpose: We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients. Methods: Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Bromfenac eye drops and the contralateral eye was treated with Pemirolast eye drops for 1 week. Subjective ocular symptoms and objective ocular signs evaluated by slit-lamp examination were scored and recorded before and after treatment. Results: Both drugs significantly decreased ocular signs after 1 week, but not symptoms. No significant differences in subjective symptoms or objective signs were observed between the two drugs. Ten patients (45.5% ) selected Bromfenac as more effective, nine patients (40.9% ) selected Pemirolast, and three patients found no difference in efficacy between the two drugs. Conclusion: Bromfenac sodium is as safe and effective for the treatment of allergic conjunctivitis as pemirolast potassium.
