The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore th...The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis （PTB）. Methods： A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science （Version 13.0） and Review Manager （Version 4.2, The Cochrane Collaboration） were used to analyze the data reported in studies. Results： A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility （allele f vs F： OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF： OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff＋FF： OR=1.39, 95%CI=[1.12, 1.71]）. No significant associations were observed between TaqI （15 studies with 3 031 cases and 3 132 controls）, ApaI （7 studies with 1 495 cases and 1 922 controls）, BsmI （6 studies with 919 cases and 1 250 controls） variants and PTB susceptibility. Conclusion： We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.展开更多
Rather than parking at nearby hourly parking lots, many passenger-picking-up vehicles prefer to idle at terminals and/or drive cycling around terminal facilities. As a result, extra vehicle emissions may be produced i...Rather than parking at nearby hourly parking lots, many passenger-picking-up vehicles prefer to idle at terminals and/or drive cycling around terminal facilities. As a result, extra vehicle emissions may be produced in an airport area. Even though there are limited studies on such emissions at airports, these estimations were normally based on the date emission models, which might cause bias in emission estimations. This paper proposes an approach to employ the floating car method and Global Positioning System （GPS） to record speeds and acceleration rates of idling and cycling vehicles at airport terminals. The tests were conducted under different time periods and traffic demands with different waiting time. The speeds and acceleration rates are synthesized to yield Vehicle Specific Power＇s （VSP） and Operational Mode （OM） distributions. Utilizing the Environmental Protection Agency （EPA） emission estimation model Motor Vehicle Emission Simulator （MOVES）, pollutants and green house gas emission indexes （e.g. NOx, CO, CO2 and HC） and fuel consumptions can be easily estimated. As an illustration of the proposed approach, the research team collected GPS data at a terminal in Houston William Hobby Airport （HOU）, and calculated the VSP distributions and OM distributions. Emissions of passenger-picking-up vehicles around these congested airport terminals.展开更多
基金Supported by the National Natural Science Foundation of China (30700685)the Medical Science and Technology Research Project of Chongqing Municipal Health Bureau (2009-1-06)
文摘The vitamin D receptor （VDR） gene is a primary candidate gene for tuberculosis susceptibility, but results of previous studies are somewhat contradictory and underpowered. Thus, it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis （PTB）. Methods： A systematic review and meta-analysis about the association between Fok[, TaqI, Apal and Bsm[ polymorphisms and PTB susceptibility was conducted. Statistical Package for Social Science （Version 13.0） and Review Manager （Version 4.2, The Cochrane Collaboration） were used to analyze the data reported in studies. Results： A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism, and the results showed FokI polymorphism was associated with PTB susceptibility （allele f vs F： OR=1.12, 95% CI=[1.02, 1.23]; the additive effect model ff vs FF： OR=1.40, 95%CI=[1.10, 1.77]; the recessive genetic model firs Ff＋FF： OR=1.39, 95%CI=[1.12, 1.71]）. No significant associations were observed between TaqI （15 studies with 3 031 cases and 3 132 controls）, ApaI （7 studies with 1 495 cases and 1 922 controls）, BsmI （6 studies with 919 cases and 1 250 controls） variants and PTB susceptibility. Conclusion： We found variant Fokl polymorphism of VDR gene may play a risky role in PTB development, and the genetic model was presumed to be recessive.
文摘Rather than parking at nearby hourly parking lots, many passenger-picking-up vehicles prefer to idle at terminals and/or drive cycling around terminal facilities. As a result, extra vehicle emissions may be produced in an airport area. Even though there are limited studies on such emissions at airports, these estimations were normally based on the date emission models, which might cause bias in emission estimations. This paper proposes an approach to employ the floating car method and Global Positioning System （GPS） to record speeds and acceleration rates of idling and cycling vehicles at airport terminals. The tests were conducted under different time periods and traffic demands with different waiting time. The speeds and acceleration rates are synthesized to yield Vehicle Specific Power＇s （VSP） and Operational Mode （OM） distributions. Utilizing the Environmental Protection Agency （EPA） emission estimation model Motor Vehicle Emission Simulator （MOVES）, pollutants and green house gas emission indexes （e.g. NOx, CO, CO2 and HC） and fuel consumptions can be easily estimated. As an illustration of the proposed approach, the research team collected GPS data at a terminal in Houston William Hobby Airport （HOU）, and calculated the VSP distributions and OM distributions. Emissions of passenger-picking-up vehicles around these congested airport terminals.
