室相性房性心律不齐一例报告

患者,女性,23岁,风心病,联合瓣膜病变史八年。因胸闷心慌加重伴咳嗽气短,不能平卧5天于90年2月17日入院。体检:BP16/8kPa(120/60mmHg),半卧位,口唇发绀,颈静脉怒张。两肺底闻及中细湿啰音。心界向左下扩大,心尖搏动弥散,HR150/min,节律不齐,心音强弱不等,心尖部闻及Ⅲ/Ⅵ级吹风样全收缩期杂音,向左腋下传导,主动脉瓣副区Ⅲ/Ⅵ级哈气样舒张期杂音。肝右肋下可触及,肝颈返流征(+),下肢无浮肿。

A Study on the Multi-Compartment Linear Circulation Pharmacokinetic Model for the Targeting Drug Delivery System

By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.

Microstructural evolution and mechanical properties of new multi-phase NiAl-based alloy during heat treatments

Microstructural evolution and the relationship between microstructure and property during heat treatments in a new NiAl-based alloy(Ni-26.6Al-13.4Cr-8.1Co-4.3Ti-1.3W-0.9Mo,molar fraction,%))were investigated.The as-cast alloy is composed of NiAl matrix and Cr3Ni2 phase with poor ductility.The Cr3Ni2 phase is distributed as a network along the NiAl grain boundaries.Subsequent heat treatment(1 523 K,20 h,air cooling+1 123 K,16 h,furnace cooling)leads to the dissolution of Cr3Ni2 phase and the precipitation of lath-shaped Ni3Al phase andα-Cr particles,resulting in the improvement of compressive properties and fracture toughness at room temperature.Followed by long-term thermal exposure(1 173 K,8 500 h),it is found that the residual Cr3Ni2 phase keeps stable while theα-Cr particles coarsen and a great mass of lath-shaped Ni3Al precipitates are degenerated,which compromises most of the above improvements of mechanical properties through heat treatment.

Direct Path Detection Method in Indoor Location

A search algorithm for the detection of a direct path signal in the presence of dense multipath in indoor environment using UWB is Woposed. This algorithm is based on signal correlation and differential coefficient. Statistical analysis of the algorithm is given out and computer simulation results are presented to validate the effectiveness of the algorithm. The results based on the algorithm pml3osed are compared with those based on Maximum Likelihood Estimator（MLE） and Peak Tracking（PT） in the simulation which shows that this algorithm achieves the highest accuracy in most cases and gives out relatively stable results in different Signal Noise Ratio（SNR）.

Phase evolution and room temperature ferroelectric and magnetic properties of Fe-doped BaTiO_3 ceramics

To make the ferroelectric BaTiO3 possess ferromagnetism simultaneously,magnetic Fe was doped into BaTiO3 ceramics at doping levels up to 10%(molar fraction).Both tetragonal and hexagonal phases coexisted in the Fe-doped BaTiO3 ceramics except at 1% doping level.X-ray diffraction analysis indicated that higher doping level of Fe,higher sintering temperature and longer sintering time promoted the formation of hexagonal phases in Fe-doped BaTiO3 ceramics.Ferroelectricity was observed in all samples at room temperature,but it was greatly depressed by Fe doping.Except at doping level of 1%,room-temperature ferromagnetism was observed in the BaTiO3 ceramics.The dependence of the saturation magnetization and coercivities of the Fe-doped BaTiO3 ceramics on doping level was systematically studied.Both the saturation magnetization and magnetic coercivities were found to be dependent on the doping level as well as the fraction of the hexagonal phase in the ceramics.

IN PATIENTS WITH HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY AND CORONARY HEART DISEASE,CORONARY FLOW RESERVE IS SIMILARLY IMPAIRED

Coronary blood flow reserve (CFR) was assessed by transesophageal Doppler echocardiography in normal subjects (group A. n=20),hypertensive non-left ventricular hypertrophy (non-LVH)Patients (group B,n=22). hypertensive patients with LVH(group C.n=32)and coronary heart disease patients (group D. n=33) with the volume sample placed at the bifurcation of the left main and left main and left descending coronary artery. Coronary blood flow velocity (CBFV)was evaluated at rest.2 minutes after dipyridamole (0. 56mg/kg. i. v.) . and 2 minutes after aminophylline i.v. The ratio of dipyridamole to rest maximal diastolic velocity (D/R PDV) was considered the index of coronary blood flow reserve.It was found that D/R PDV was significantly less in groups C and D compared with that in groups A and B (D PDC,1.84±0. 57. 1. 57±0. 41 versus 2.59±0.70 and 2.22+0.58,respectively),with no difference in D/R PDV between groups C and D.Twenty-four out of 32 patients in group C with D/R PDV were less than 2.0 compared to 29 out of 33 patients in group D (P>0.05).Significant negative correlation was found between D/R PDV. D/R PSV and interseptal thickness. left ventricular mass index in hypertensive patients.These data show that impaired CFR in hypertensive patients with LVH is comparable to that in patients with coronary heart disease.

Microscopic Superconductivity and Room Temperature Electronics of High-T_c Cuprates

Abstract This paper points out that the Landau criterion for macroscopic superfluidity of He H is only a criterion for microscopic superfluidity of ^4He, extends the Landau criterion to microscopic superconductivity in fermions （electron and hole） system and system with Cooper pairs without long-range phase coherence. This paper gives another three non-superconductive systems that are of microscopic superconductivity. This paper demonstrates that one application of microscopic superconductivity is to establish room temperature electronics of the high-To cuprates.

Technical Procedure Determination of Thoron Indoor Concentration by LR-115 Type II

Thoron （Rn-220） is an invisible, odorless radioactive gas and nine times heavier than air. Purpose of project is to set up procedure to determine Rn-220 concentration which has been carried out in laboratory using Solid State Nuclear Track Detector （SSNTD） based passive detector technique. In this study, technical procedure has been applied in Karlsruhe diffusion chamber and LR-115, Type II strippable （Kodak Pathe, France） detector. The results have investigated how LR-115 work for Rn-220 by using Monazite ore to simultaneously measure Rn-222 and Rn-220. To carry out experiment, Karlsruhe diffusion chamber is used to with and without Poly-Ethylene （PE） membrane. Karlsruhe diffusion chamber with PE membrane only detect Rn-222, without PE membrane detect total Rn-222 and Rn-220. Precision evaluation by duplicate measure at 8 cm detector-source distance with relative standard deviation is less than 2.54%. Testing technical procedure, detectors have been sent to National Institute of Radiological Science （NIRS） for Rn-220 calibration exposure. After detectors have been calibration exposure at NIRS, it carried out all the following steps of procedure which set up at laboratory in 1NST, Vietnam. Finally, calibration factor calculated is 0.21 （tracks-cm2/Bq·m3·h） and constructed curve between integrated Tn-220 concentration and tracks density with factor R2 = 0.975.

A Report on Identification, Segregation, Disposal and Reduction of Chemical Wastes

The accumulation of generated chemical wastes posed a serious problem for the UP College of Pharmacy. The faculty from the Department of Pharmaceutical Chemistry devised a scheme for the identification and segregation of the chemical wastes and created a system for proper disposal of future chemical wastes. There were a total of 1,142 of accumulated chemical waste bottles, 804 of which were subjected to identification and segregation procedures. The wastes were preliminarily tested for its solubility/miscibility in water and acidity or basicity. The identification was done by qualitative tests for cyanide, sulfide, halogenated, non-halogenated, oxidizing, nitro, and heavy metal compounds. The final segregation was based on the presence of the most hazardous component or on pH and water-miscibility. The Department then developed and implemented a scheme for the proper disposal of the chemical wastes generated in laboratory experiments done in the College. Laboratory experiments were also modified to use less toxic and less amounts of chemicals.

Experimental investigation of three-dimensional mixed-mode fracture of a titanium alloy at room and elevated temperatures

Damage tolerance of titanium alloy structures is very important for the safety of modern aircraft under complex loading and environmental conditions. However, there is no available systematic knowledge about the effect of alloy thickness under mixed-mode loading at elevated temperatures. In the present study, a newly developed fracture experimental technique based on high-temperature moiré interferometry was employed to investigate experimentally I-II mixed-mode fracture in titanium alloy TC11 of various thicknesses at room and elevated temperatures. Compact shear specimens with thickness ranging from 1.8 to 7.1 mm were tested. The effects of temperature, thickness, and loading angle on the load capacity and crack initiation angle were investigated systematically. The TC11 alloy was shown to possess varied fracture performance at elevated tem-perature, and an opposite thickness effect at room temperature. Increasing temperature would enhance the fracture load capacity of thick specimens but reduce the fracture load capacity of thin specimens. Crack initiation angles under I-II mixed-mode loading showed the thickness-temperature coupling effects. These complex effects call for new development in three-dimensional mixed-mode fracture theory and technologies for damage tolerance assessment.

Biocompatible metal-free organic phosphorescent nanoparticles for efficiently multidrug-resistant bacteria eradication

Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen(1O2) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly efficient antibacterial agent. Herein, we report bright red-emissive organic phosphorescent nanoparticles(PNPs) based on a metal-free organic phosphor encapsulated with biocompatible block copolymers. The obtained PNPs with an ultra-small particle size of around 5 nm and a long emission lifetime of up to 167 μs showed effective 1O2 generation ability under visible light(410 nm) excitation in aqueous media, which can efficiently eradicate multi-drug resistant bacteria both in vitro and in vivo. This is the first demonstration of metal-free organic PNPs for photodynamic antimicrobial therapy, expanding the application scope of metal-free organic room temperature phosphorescent materials.

Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature

DNA persistence length is a key parameter for quantitative interpretation of the conformational properties of DNA and related to the bending rigidity of DNA.A series of experiments pointed out that,in the DNA condensation process by multivalent cations,the condensed DNA takes elongated coil or compact globule states and the population of the compact globule states increases with an increase in ionic concentration.At the same time,single molecule experiments carried out in solution with multivalent cations(such as spermidine,spermine)indicated that DNA persistence length strongly depends on the ionic concentration.In order to revolve the effects of ionic concentration dependence of persistence length on DNA condensation,a model including the ionic concentration dependence of persistence length and strong correlation of multivalent cation on DNA is provided.The autocorrelation function of the tangent vectors is found as an effective way to detect the ionic concentration dependence of toroidal conformations.With an increase in ion concentration,the first periodic oscillation contained in the autocorrelation function shifts,the number of segment contained in the first periodic oscillation decreases gradually.According to the experiments,the average long-axis length is defined to estimate the ionic concentration dependence of condensation process further.The relation between long-axis length and ionic concentration matches the experimental results qualitatively.