目的研究宫内暴露尼古丁对生后小鼠大脑皮层神经细胞凋亡的影响。方法建立妊娠期宫内暴露尼古丁小鼠动物模型,观察生后21天小鼠大脑皮层组织结构变化,免疫组织化学方法和W estern b lot方法检测宫内暴露尼古丁模型大脑皮层caspase-3的...目的研究宫内暴露尼古丁对生后小鼠大脑皮层神经细胞凋亡的影响。方法建立妊娠期宫内暴露尼古丁小鼠动物模型,观察生后21天小鼠大脑皮层组织结构变化,免疫组织化学方法和W estern b lot方法检测宫内暴露尼古丁模型大脑皮层caspase-3的表达。结果尼古丁组小鼠大脑皮层脑回厚度较对照组变薄(P<0.05),免疫组织化学法检测到大脑皮层caspase-3阳性反应物的平均光密度值在尼古丁组高于对照组(P<0.05),W estern b lot方法检测到大脑皮层caspase-3酶原(32KD)形式及活性片段形式(17KD、20KD)的相对表达量高于对照组(P<0.01)。结论孕期宫内暴露尼古丁激活生后小鼠大脑皮层神经细胞caspase-3的过表达,参与大脑皮层神经细胞凋亡。展开更多
挪威和美国研究者称，妇女产前子宫内暴露于己烯雌酚与孕期出现先兆子痫的风险轻度升高有关。
研究数据来自美国国立癌症研究院己烯雌酚队列随防研究（National Cancer Institute DES Combined Cohorts Follow—up Study）在7313例活...挪威和美国研究者称，妇女产前子宫内暴露于己烯雌酚与孕期出现先兆子痫的风险轻度升高有关。
研究数据来自美国国立癌症研究院己烯雌酚队列随防研究（National Cancer Institute DES Combined Cohorts Follow—up Study）在7313例活产妇女中，明确为先兆子痫的有285例，展开更多
Objective:To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin r euptake inhibitors(SSRIs)in utero.Design:Cohort study.Setti...Objective:To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin r euptake inhibitors(SSRIs)in utero.Design:Cohort study.Setting:Tertiary car e center.Patients:One hundred twenty term infants,of whom 60 had prolonged in utero exposure to SSRIs,including paroxetine hydrochloride,fluoxetine,citalo pram hydrobromide,sertraline hydrochloride,and venlafaxine hydrochloride.Main Outcome Measures:Neonatal abstinence syndrome was assessed with the Finnegan s core as follows:score of 8 or above,severe;score of 4 to 7,mild;and score o f 0 to 3,normal.All infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring u ntil normalization of the Finnegan score.Results:Of the 60 neonates exposed to SSRIs in utero,8 showed severe and 10 showed mild symptoms of a neonatal absti nence syndrome.All nonexposed neonates had a normal Finnegan score.In neonates who developed severe symptoms,the maximum mean daily Finnegan scores were reco rded within 2 days after birth,although maximum individual scores were recorded as long as 4 days after birth.Conclusions:Neonatal abstinence syndrome occurs in 30%of neonates exposed to SSRIs in utero.These neonates should be monitore d for at least 48 hours after birth.The longterm effects of prolonged exposure to SSRIs,particularly in neonates who develop severe symptoms,have yet to be d etermined.展开更多
子痫前期(preeclampsia,PE),尤其是足月前发生的PE,会增加儿童神经发育不良结局的风险。Costantine等^([1])进行了一项研究,旨在确定PE高危孕妇应用普伐他汀治疗对子代健康、生长和神经发育的影响。该研究的对象是参加产科-胎儿药理学...子痫前期(preeclampsia,PE),尤其是足月前发生的PE,会增加儿童神经发育不良结局的风险。Costantine等^([1])进行了一项研究,旨在确定PE高危孕妇应用普伐他汀治疗对子代健康、生长和神经发育的影响。该研究的对象是参加产科-胎儿药理学研究中心网络(Obstetric-Fetal PharmacologyResearchCentersNetwork)普伐他汀与安慰剂用于PE高风险个体的探索性研究(pilottrialsofpravastatin vs placebo in individuals at high risk of preeclampsia)的受试者的子代。展开更多
文摘目的研究宫内暴露尼古丁对生后小鼠大脑皮层神经细胞凋亡的影响。方法建立妊娠期宫内暴露尼古丁小鼠动物模型,观察生后21天小鼠大脑皮层组织结构变化,免疫组织化学方法和W estern b lot方法检测宫内暴露尼古丁模型大脑皮层caspase-3的表达。结果尼古丁组小鼠大脑皮层脑回厚度较对照组变薄(P<0.05),免疫组织化学法检测到大脑皮层caspase-3阳性反应物的平均光密度值在尼古丁组高于对照组(P<0.05),W estern b lot方法检测到大脑皮层caspase-3酶原(32KD)形式及活性片段形式(17KD、20KD)的相对表达量高于对照组(P<0.01)。结论孕期宫内暴露尼古丁激活生后小鼠大脑皮层神经细胞caspase-3的过表达,参与大脑皮层神经细胞凋亡。
文摘挪威和美国研究者称，妇女产前子宫内暴露于己烯雌酚与孕期出现先兆子痫的风险轻度升高有关。
研究数据来自美国国立癌症研究院己烯雌酚队列随防研究（National Cancer Institute DES Combined Cohorts Follow—up Study）在7313例活产妇女中，明确为先兆子痫的有285例，
文摘Objective:To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin r euptake inhibitors(SSRIs)in utero.Design:Cohort study.Setting:Tertiary car e center.Patients:One hundred twenty term infants,of whom 60 had prolonged in utero exposure to SSRIs,including paroxetine hydrochloride,fluoxetine,citalo pram hydrobromide,sertraline hydrochloride,and venlafaxine hydrochloride.Main Outcome Measures:Neonatal abstinence syndrome was assessed with the Finnegan s core as follows:score of 8 or above,severe;score of 4 to 7,mild;and score o f 0 to 3,normal.All infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring u ntil normalization of the Finnegan score.Results:Of the 60 neonates exposed to SSRIs in utero,8 showed severe and 10 showed mild symptoms of a neonatal absti nence syndrome.All nonexposed neonates had a normal Finnegan score.In neonates who developed severe symptoms,the maximum mean daily Finnegan scores were reco rded within 2 days after birth,although maximum individual scores were recorded as long as 4 days after birth.Conclusions:Neonatal abstinence syndrome occurs in 30%of neonates exposed to SSRIs in utero.These neonates should be monitore d for at least 48 hours after birth.The longterm effects of prolonged exposure to SSRIs,particularly in neonates who develop severe symptoms,have yet to be d etermined.
文摘子痫前期(preeclampsia,PE),尤其是足月前发生的PE,会增加儿童神经发育不良结局的风险。Costantine等^([1])进行了一项研究,旨在确定PE高危孕妇应用普伐他汀治疗对子代健康、生长和神经发育的影响。该研究的对象是参加产科-胎儿药理学研究中心网络(Obstetric-Fetal PharmacologyResearchCentersNetwork)普伐他汀与安慰剂用于PE高风险个体的探索性研究(pilottrialsofpravastatin vs placebo in individuals at high risk of preeclampsia)的受试者的子代。
