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Galectin-3、VEGF-C、SFRP1在宫颈鳞癌、宫颈上皮内瘤变及宫颈炎组织中的表达及其临床意义 被引量:7
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作者 刘艳 冯宁 《检验医学与临床》 CAS 2022年第15期2073-2077,共5页
目的分析Galectin-3、血管内皮生长因子C(VEGF-C)、分泌型卷曲相关蛋白1(SFRP1)在宫颈鳞癌、宫颈上皮内瘤变(CIN)及宫颈炎组织中的表达及其临床意义。方法采集2016年7月至2020年8月在该院手术切除并经手术病理组织学证实为宫颈鳞癌标本5... 目的分析Galectin-3、血管内皮生长因子C(VEGF-C)、分泌型卷曲相关蛋白1(SFRP1)在宫颈鳞癌、宫颈上皮内瘤变(CIN)及宫颈炎组织中的表达及其临床意义。方法采集2016年7月至2020年8月在该院手术切除并经手术病理组织学证实为宫颈鳞癌标本57份,因CIN而行宫颈椎切或子宫全切的宫颈组织标本57份,另选取48份慢性宫颈炎活检标本;采用免疫组织化学法检测宫颈鳞癌、CIN及宫颈炎组织中Galectin-3、VEGF-C、SFRP1阳性表达率,并分析其与宫颈鳞癌、CIN临床病理特征的关系。结果(1)Galectin-3、VEGF-C阳性表达率在宫颈鳞癌、CIN、宫颈炎组织中依次降低(P<0.05);而宫颈鳞癌、CIN中SFRP1阳性表达则较宫颈炎组织均明显下降(P<0.05);(2)Galectin-3、VEGF-C阳性表达率随国际妇产科联盟(FIGO)分期及CIN分级增加而上升,且低分化程度组织阳性表达率高于中分化及高分化组织,CINⅢ级阳性表达率高于Ⅰ级、Ⅱ级(P<0.05);有淋巴结转移的宫颈鳞癌组织与无淋巴结转移的宫颈鳞癌组织中Galectin-3阳性表达率差异无统计学意义(P>0.05),而有淋巴结转移的宫颈鳞癌组织中VEGF-C阳性表达率高于无淋巴结转移的宫颈鳞癌组织中VEGF-C蛋白阳性表达率(P<0.05);(3)SFRP1在宫颈鳞癌组织中的阳性表达率则随FIGO分期增加而下降,且低分化组织阳性表达率低于中分化及高分化组织,有淋巴结转移组织阳性表达率低于无淋巴结转移组织(P<0.05),同时不同分级的CIN中SFRP1阳性表达率虽差异无统计学意义(P>0.05),但CINⅢ级组织中SFRP1阳性表达率低于Ⅰ级、Ⅱ级(P<0.05)。结论Galectin-3、VEGF-C高阳性表达、SFRP1低阳性表达或与宫颈鳞癌FIGO分期、组织学分化程度、淋巴结转移及CIN分级有一定关联性,仍需进一步深入探究。 展开更多
关键词 GALECTIN-3 血管内皮生长因子C 分泌型卷曲相关蛋白 宫颈鳞癌 宫颈上皮内瘤变 宫颈炎组织
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Cervical cellulitis and mediastinitis following esophageal perforation:A case report 被引量:3
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作者 Christian A Righini Basilide Z Tea +1 位作者 Emile Reyt Karim A Chahine 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第9期1450-1452,共3页
Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation. Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management... Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation. Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management. We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis. Following CT-scan evidence of FB penetrating the esophagus, the impacted FB was successfully extracted under rigid esophagoscopy. Direct suture was required to close the esophageal perforation. Cervical and mediastinal drainage were made immediately. Naso- gastric tube decompression, broad-spectrum intravenous antibiotics, and parenteral hyperalimentation were administered for 10 d postoperatively. An esophagogram at d 10 revealed no leak at the repair site, and oral alimentation was successfully reinstituted. Conclusion: Rigid endoscope management of FB esophageal penetration is a simple, safe and effective procedure. Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications. 展开更多
关键词 ESOPHAGUS PERFORATION Foreign body MEDIASTINITIS Surgery
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