人流术前宫颈管灌注盐酸丁卡因胶浆镇痛的临床观察(附163例报告)

目的:评价宫颈管灌注盐酸丁卡因胶浆在人工流产术中的镇痛效果。方法:设宫颈管灌注盐酸丁卡因胶浆组、`宫颈注射利多卡因组和对照组。灌注组于人流术前在宫颈管内涂抹注入盐酸丁卡因胶浆,注射组在宫颈10点、4点分别注射利多卡因,对照组不用任何药物,观察孕妇术中对疼痛的自我感觉及宫口的松弛情况。结果:灌注组和注射组的镇痛及宫颈内口松弛效果完全相同,均无1例人流综合征发生,但注射组有注射处出血或可能操作不当造成损伤及孕妇恐惧肌肉注射的情况,对照组无镇痛处置,易发生人流综合征及人流不全。结论:人流术前宫颈管灌注盐酸丁卡因胶浆镇痛是一种安全可靠、操作简便、效果好、无损伤及出血的新方法。

Effect of intraarterial chemotherapy on vascular endothelial growth factor expression and microvessel density in carcinoma of the cervix

Objective: To clarify the effect of intraarterial chemotherapy on vascular endothelial growth factor (VEGF) expres- sion and microvessel density (MVD) count in carcinoma of the cervix. Methods: Before intraarterial chemotherapy and after 2–3 weeks of therapy, the expression of VEGF and MVD count in 36 carcinoma tissues of locally advanced cervical cancer were determined by CD34. Results: Before intraarterial chemotherapy and after 2–3 weeks, the expression of VEGF were 75% (27/36) and 30.6% (11/36) respectively, and MVD were reduced obviously (P<0.001). Conclusion:?The intraarterial chemotherapy can reduce the expression of VEGF and MVD, and adjust malignancy of cervical cancer, and cut down the postoperative metastasis.