In order to solve the urgent problem of how to manage and sustain highway tunnels with advanced information technology with the background of the rapid development in the modem traffic, and achieve the cost- effective...In order to solve the urgent problem of how to manage and sustain highway tunnels with advanced information technology with the background of the rapid development in the modem traffic, and achieve the cost- effectiveness optimal principle objectives under the premise of guaranteeing a smooth flow of traffic; a highway tunnel maintenance and management system framework and the key modules were proposed. First, the determined highway tunnel condition assessment index system was established according to the result of expert consulting forms. Secondly, the tunnel diseases, the corresponding maintenance measurements, and many-to-many relationship between diseases and maintenance measurements were introduced. Then, three kinds of 0-1 integer programming models were built according to different tunnel operators' needs in the optimization decision module. Finally, the further development and implementation of the system was prospected. The research results can provide references to tunnel researchers and managers.展开更多
Fusarium head blight (FHB) caused by Fusarium graminearum is a devastating disease that results in extensive yield losses to wheat and barley. A green fluorescent protein (GFP) expressing plasmid pRP22-GFP was constru...Fusarium head blight (FHB) caused by Fusarium graminearum is a devastating disease that results in extensive yield losses to wheat and barley. A green fluorescent protein (GFP) expressing plasmid pRP22-GFP was constructed for monitoring the colonization of two biocontrol agents, Brevibacillus brevis ZJY-1 and Bacillus subtilis ZJY-116, on the spikes of barley and their effect on suppression of FHB. Survival and colonization of the Brevibacillus brevis ZJY-1 and Bacillus subtilis ZJY-116 strains on spikes of barley were observed by tracking the bacterial transformants with GFP expression. Our field study revealed that plasmid pRP22-GFP was stably maintained in the bacterial strains without selective pressure. The retrieved GFP-tagged strains showed that the bacterial population fluctuation accorded with that of the rain events. Furthermore, both biocontrol strains gave significant protection against FHB on spikes of barley in fields. The greater suppression of barley FHB disease was resulted from the treat-ment of barley spikes with biocontrol agents before inoculation with F. graminearum.展开更多
The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam (FIB) microanalysis and finite element...The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam (FIB) microanalysis and finite element (FE) simulation. The SEM results show that the electromigration-induced local degradation of microstructures, i.e., segregation of Bi-rich phase and formation of microcracks, in the asymmetric solder interconnects is much severer than that in the symmetrical ones. FIB-SEM microanalysis reveals that the microregional heterogeneity in electrical resistance along different electron flowing paths is the key factor leading to non-uniform current distribution and the resultant electromigration damage. Theoretical analysis and FE simulation results manifest that the current crowding easily occurs at the local part with smaller resistance in an asymmetric solder interconnect. All results indicate that the asymmetric shape of the solder interconnect brings about the difference of the electrical resistance between the different microregions and further results in the severe electromigration damage.展开更多
AIM: To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwan Residents adults, and to evaluate their possible interaction in inducing liver damage (LD). From ...AIM: To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwan Residents adults, and to evaluate their possible interaction in inducing liver damage (LD). From an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host immune response to HBV infection and enhances liver damage.METHODS: A cross-sectional retrospective analysis of health records including medical history, physical examination, abdominal sonogram, blood biochemistry and hepatic virological tests. We utilized the Student's t-test, chi-square, multivariate logistic regression and synergy index to assess risks for LD.RESULTS: Among a total of 5406 Taiwan Residents adults (mean age 46.2 years, 51.5% males), the prevalence of LD, HBVC and SFL were 12.3%, 15.1% and 33.4%, respectively; 5.1% of participants had SFL plus HBVC. Multivariate logistic regression analysis demonstrated that male gender (odds ratio (OR) = 2.8, 95% confidence interval (CI): 2.3-3.5), overweight state (OR = 1.6, 95% CI: 1.3-2.0), HBVC (OR = 2.5, 95% CI: 2.0-3.1) and SFL (OR = 4.2, 95% CI: 2.2-5.3) were independently associated with LD. Synergism analysis showed that the adjusted OR for LD in adults with HBVC-alone was 3.3 (95% CI: 2.4-4.6), SFL-alone, 4.7 (95% CI: 3.7-6.1) and combined HBVC and SFL, 9.5 (95% CI: 6.8-13.3); the synergy index was 1.4 (95% CI: 1.001-2.0).CONCLUSION: In Taiwan Residents adults, SFL plus HBVC have a significant synergistic association with LD.展开更多
Numerical simulation has been widely applied to the assessment of debris flow hazards. In East Asia and especially Taiwan, the most widely used numerical programs are FLO-2D and Debris-aD. Although these two programs ...Numerical simulation has been widely applied to the assessment of debris flow hazards. In East Asia and especially Taiwan, the most widely used numerical programs are FLO-2D and Debris-aD. Although these two programs are applied to the same engineering tasks, they are different in many aspects. These two programs were compared according to their fundamental theories, input and output data, computational algorithms and results. Using both programs, the simulations of a real debris flow with abundant granular material induced by landslides at Xinfa village in southern Taiwan are performed for comparison. The simulation results show that Debris- 2D gives better assessment in hazard area delineating and flow depth predicting. Therefore, Debris-2D is better for simulation of granular debris flows.展开更多
Floods have been popularly understood as the nightmares of human beings for their devastation causes. Floods in traditional Vietnamese minds are of the same type since ancient Vietnamese used a metaphor to address the...Floods have been popularly understood as the nightmares of human beings for their devastation causes. Floods in traditional Vietnamese minds are of the same type since ancient Vietnamese used a metaphor to address the floods in Red River Delta (Hanoi area) as un-auspicious marine spirit Thuy Tinh being defeated by the inland spirit Son Tinh in the legendary battle of life. Therefore, as being expressed in many cultures, floods are symbol of death and loss, and human beings have always attempted to get rich of or overcome the floods. However, the floods, under the awareness and pragmatic life of the people of An Giang Province as well as the whole Mekong River Delta (in Southern Vietnam), the floods are considered as the sign of wealth and happiness. What makes the floods to be so auspiciously acknowledged, and how do people manage to ~exploit" the floods to enrich their life? This paper is to investigate and generalize the approaches of utilizing the floods' resources to diversify their life, especially in cuisine culture. The research learns that the regularly stable floods in the Mekong River system strongly and positively affects the life of the local residents, and the community is further wise to exploit and transform the natural resources into their cultural world, mentally and materially, among which, ecotourism is a potentially prospective field展开更多
It is difficult to manage the manufacturing hazardous waste (MHW) which is generated from a huge amount of compli- cated sources and causes very serious pollution. Therefore more and more attention has been paid to MH...It is difficult to manage the manufacturing hazardous waste (MHW) which is generated from a huge amount of compli- cated sources and causes very serious pollution. Therefore more and more attention has been paid to MHW pollution. Shanghai, as an industrial and economic center and an international metropolis in China, has a vast industrial system spanning a multitude of sectors, which generates MHW not only in a huge magnitude but also in a large variety of types from complicated sources, resulting in severe pollution. In 2003, the production of MHW in Shanghai is about 3.96 × 105 ton, involving 33 indices. Most of MHW in Shanghai is treated and disposed of, but a significant portion is not handled properly and effectively. This paper carries out in-field investigation on the current status of MHW production and treat- ment in Shanghai, and puts forward scientific proposals that Shanghai should facilitate cleaner production and minimize haz- ardous waste; strictly enforce hazardous waste registration system, strengthen monitoring the certified enterprises; strengthen intent disposal center construction and realize hazardous waste reclama- tion; accelerate establishing the technical criteria and the man- agement policy, promote the research and development on the treatment and disposal technology, and strengthen information management, thus realizing integrated management on MHW pollution.展开更多
In order to analyze the influence of vapor cloud shape on temperature field effect of unconfined vapor cloud explosion(UVCE)and obtain creditable prediction method of explosion temperature effect,the transient tempera...In order to analyze the influence of vapor cloud shape on temperature field effect of unconfined vapor cloud explosion(UVCE)and obtain creditable prediction method of explosion temperature effect,the transient temperature fields of cylindrical and hemispherical UVCEs with same methane concentration and mass were numerically studied by computational fluid dynamics(CFD)technology.According to numerical simulation results, the concepts of UVCE’s temperature-near-field and temperature-far-field were proposed,the corresponding ranges were given,and the temperature attenuation laws and differences in corresponding regions with different vapor cloud shapes were presented.Through comparing with Baker fireball model,the accuracy and visualizability in acquisition of entire temperature effect based on numerical simulation were further validated.The functional relations among maximum temperature,horizontal distance,initial temperature and vapor cloud mass in temperature-near-field and temperature-far-field were deduced by means of data fitting,respectively.These conclusions provided quantitative basis for forecast and protection of UVCE disaster.展开更多
Introduction of foreign plants and animals into Thailand's ecology has a long history, some arrived accidentally and others had a purpose. As global commerce increases, the issue of invasive alien species has become ...Introduction of foreign plants and animals into Thailand's ecology has a long history, some arrived accidentally and others had a purpose. As global commerce increases, the issue of invasive alien species has become more urgent in Thailand. These agents are increasingly seen as a threat not only to biodiversity and ecosystem, but also to economic development and human well-being. They reduce yields of agricultural crops, forests and fisheries, decrease water availability, cause costly land degradation, block transport routes and contribute to the spread of disease. It is clear that since trade will not stop, dangerous alien species need to be controlled and managed and the strategies and control measures are to prevent, eradicate, contain, or effectively control the invaders. Implementation of these measures requires appropriate legislation, regulation and procedures. The impact of some invasive alien pests and their management on the agricultural sector of Thailand are presented.展开更多
Objective The present retrospective study was to explore the clinical value of Six-Item Screener (SIS), which is constituted by 6 items from mini-mental status examination (MMSE), to identify cognitive impairment....Objective The present retrospective study was to explore the clinical value of Six-Item Screener (SIS), which is constituted by 6 items from mini-mental status examination (MMSE), to identify cognitive impairment. Methods A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups: subjective memory complaints (SMCs) (475 cases), patients with mild cognitive impairment (MCI) (440 cases), and patients with Alzheimer's disease (AD) (1061 cases, including 555 mild, 339 moderate, and 167 severe). A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background. Results The cut-off of SIS score was 〈 2 for illiterate, 〈 3 for elementary, and 〈 4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%. Conclusion SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.展开更多
OBJECTIVE: To establish an animal model of tractive spinal cord injury in rats in order to investigate its pathophysiological changes and clinical significance. METHODS: T(12)-L(3) spines were tracted longitudinally w...OBJECTIVE: To establish an animal model of tractive spinal cord injury in rats in order to investigate its pathophysiological changes and clinical significance. METHODS: T(12)-L(3) spines were tracted longitudinally with a special spinal retractor that was put on the proccessus transverses of T(12)-L(3) vertebrae of the rat after exposing T(13)-L(2) spinal cord via dual laminectomy. At the same tine, the spinal cord function was monitored by cortical somatosensory evoked potential (CSEP). Rats were randomly divided into four groups according to the amplitude of CSEP P(1)-N(1) wave, the amount of the decreasing P(1)-N(1) wave was 30% (the 30% group), 50% (the 50% group) and 70% (the 70% group), respectively. After traction, the changes of the neural behavioral function in rats were observed and the morphological structure of the spinal cord was analyzed quantitatively with image analysis system of computer. RESULTS: With traction of spine, compared with the control group, the 30% group had no marked difference in combined behavioral score (CBS), neuron count, section area of neuron and Nissl body density, but the 50% and 70% groups had marked difference (P展开更多
Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder(PTSD). PTSD is a fear-based disorder,characterized by difficulties in extinguishing the learned fear response and maintaining ex...Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder(PTSD). PTSD is a fear-based disorder,characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However,the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory. This review discusses research that targeted extinction and reconsolidation to manipulate fear memory. Recent studies indicate that sleep is an active state that can regulate memory processes. We also discuss the influence of sleep on fear memory. For each manipulation, we briefly summarize the neural mechanisms that have been identified in human studies. Finally, we highlight potential limitations and future directions in the field to better translate existing interventions to clinical settings.展开更多
This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and t...This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and tumorigenicity experiments (Keiding, 1991; Sun, 2006) and several approaches have been proposed for the additive hazards model with univariate current status data (Linet M., 1998; Martinussen and Scheike, 2002). For bivariate data, in addition to facing the same problems as those with univariate data, one needs to deal with the association or correlation between two related failure time variables of interest. For this, we employ the copula model and an efficient estimation procedure is developed for inference. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. An illustrative example is provided.展开更多
In this paper, a pest control model with state-dependent impulses is firstly established, which relies on releasing of natural enemies, together with spraying pesticides. By using the successor function of differentia...In this paper, a pest control model with state-dependent impulses is firstly established, which relies on releasing of natural enemies, together with spraying pesticides. By using the successor function of differential equation geometry rules, the existence of order one periodic solution is discussed. According to the Analogue of Poincare's Criterion, the orbitally asymptotic stability of the order one periodic solution is obtained. Furthermore, we investigated the global attractor of the system. From a biological point of view, our results indicate that: (1) the pest population can be controlled below some threshold; (2) compared to single measure, it is more efficient to take two measures for reducing the level of the pests.展开更多
Detection of crop health conditions plays an important role in making control strategies of crop disease and insect damage and gaining high-quality production at late growth stages. In this study, hyperspectral reflec...Detection of crop health conditions plays an important role in making control strategies of crop disease and insect damage and gaining high-quality production at late growth stages. In this study, hyperspectral reflectance of rice panicles was measured at the visible and near-infrared regions. The panicles were divided into three groups according to health conditions: healthy panicles, empty panicles caused by Nilaparvata lugens St^l, and panicles infected with Ustilaginoidea virens. Low order derivative spectra, namely, the first and second orders, were obtained using different techniques. Principal component analysis (PCA) was performed to obtain the principal component spectra (PCS) of the foregoing derivative and raw spectra to reduce the reflectance spectral dimension. Support vector classification (SVC) was employed to discriminate the healthy, empty, and infected panicles, with the front three PCS as the in- dependent variables. The overall accuracy and kappa coefficient were used to assess the classification accuracy of SVC. The overall accuracies of SVC with PCS derived from the raw, first, and second reflectance spectra for the testing dataset were 96.55%, 99.14%, and 96.55%, and the kappa coefficients were 94.81%, 98.71%, and 94.82%, respectively. Our results demonstrated that it is feasible to use visible and near-infrared spectroscopy to discriminate health conditions of rice panicles.展开更多
Bats play important roles as pollen disseminators and pest predators.However,recent interest has focused on their role as natural reservoirs of pathogens associated with emerging infectious diseases.Prior to the outbr...Bats play important roles as pollen disseminators and pest predators.However,recent interest has focused on their role as natural reservoirs of pathogens associated with emerging infectious diseases.Prior to the outbreak of severe acute respiratory syndrome(SARS),about 60 bat virus species had been reported.The number of identified bat viruses has dramatically increased since the initial SARS outbreak,and most are putative novel virus species or genotypes.Serious infectious diseases caused by previously identified bat viruses continue to emerge throughout in Asia,Australia,Africa and America.Intriguingly,bats infected by these different viruses seldom display clinical symptoms of illness.The pathogenesis and potential threat of bat-borne viruses to public health remains largely unknown.This review provides a brief overview of bat viruses associated with emerging human infectious diseases.展开更多
基金The US National Science Foundation(No.CM M I-0408390,CM M I-0644552)the National Natural Science Foundation of China(No.U1134206,51250110075,51150110478)+1 种基金the Western Project of M inistry of Communications of China(No.0901005C)the Natural Science Foundation of Jiangsu Province(No.BK200910046)
文摘In order to solve the urgent problem of how to manage and sustain highway tunnels with advanced information technology with the background of the rapid development in the modem traffic, and achieve the cost- effectiveness optimal principle objectives under the premise of guaranteeing a smooth flow of traffic; a highway tunnel maintenance and management system framework and the key modules were proposed. First, the determined highway tunnel condition assessment index system was established according to the result of expert consulting forms. Secondly, the tunnel diseases, the corresponding maintenance measurements, and many-to-many relationship between diseases and maintenance measurements were introduced. Then, three kinds of 0-1 integer programming models were built according to different tunnel operators' needs in the optimization decision module. Finally, the further development and implementation of the system was prospected. The research results can provide references to tunnel researchers and managers.
基金Project supported by the National Natural Science Foundation of China (No. 30230250)Science and Technology Committee of Zhejiang Province (No. 2003C22029), China
文摘Fusarium head blight (FHB) caused by Fusarium graminearum is a devastating disease that results in extensive yield losses to wheat and barley. A green fluorescent protein (GFP) expressing plasmid pRP22-GFP was constructed for monitoring the colonization of two biocontrol agents, Brevibacillus brevis ZJY-1 and Bacillus subtilis ZJY-116, on the spikes of barley and their effect on suppression of FHB. Survival and colonization of the Brevibacillus brevis ZJY-1 and Bacillus subtilis ZJY-116 strains on spikes of barley were observed by tracking the bacterial transformants with GFP expression. Our field study revealed that plasmid pRP22-GFP was stably maintained in the bacterial strains without selective pressure. The retrieved GFP-tagged strains showed that the bacterial population fluctuation accorded with that of the rain events. Furthermore, both biocontrol strains gave significant protection against FHB on spikes of barley in fields. The greater suppression of barley FHB disease was resulted from the treat-ment of barley spikes with biocontrol agents before inoculation with F. graminearum.
基金Project(51275178)supported by the National Natural Science Foundation of ChinaProject(20110172110003)supported by ResearchFund for the Program of Higher Education of China
文摘The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam (FIB) microanalysis and finite element (FE) simulation. The SEM results show that the electromigration-induced local degradation of microstructures, i.e., segregation of Bi-rich phase and formation of microcracks, in the asymmetric solder interconnects is much severer than that in the symmetrical ones. FIB-SEM microanalysis reveals that the microregional heterogeneity in electrical resistance along different electron flowing paths is the key factor leading to non-uniform current distribution and the resultant electromigration damage. Theoretical analysis and FE simulation results manifest that the current crowding easily occurs at the local part with smaller resistance in an asymmetric solder interconnect. All results indicate that the asymmetric shape of the solder interconnect brings about the difference of the electrical resistance between the different microregions and further results in the severe electromigration damage.
文摘AIM: To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwan Residents adults, and to evaluate their possible interaction in inducing liver damage (LD). From an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host immune response to HBV infection and enhances liver damage.METHODS: A cross-sectional retrospective analysis of health records including medical history, physical examination, abdominal sonogram, blood biochemistry and hepatic virological tests. We utilized the Student's t-test, chi-square, multivariate logistic regression and synergy index to assess risks for LD.RESULTS: Among a total of 5406 Taiwan Residents adults (mean age 46.2 years, 51.5% males), the prevalence of LD, HBVC and SFL were 12.3%, 15.1% and 33.4%, respectively; 5.1% of participants had SFL plus HBVC. Multivariate logistic regression analysis demonstrated that male gender (odds ratio (OR) = 2.8, 95% confidence interval (CI): 2.3-3.5), overweight state (OR = 1.6, 95% CI: 1.3-2.0), HBVC (OR = 2.5, 95% CI: 2.0-3.1) and SFL (OR = 4.2, 95% CI: 2.2-5.3) were independently associated with LD. Synergism analysis showed that the adjusted OR for LD in adults with HBVC-alone was 3.3 (95% CI: 2.4-4.6), SFL-alone, 4.7 (95% CI: 3.7-6.1) and combined HBVC and SFL, 9.5 (95% CI: 6.8-13.3); the synergy index was 1.4 (95% CI: 1.001-2.0).CONCLUSION: In Taiwan Residents adults, SFL plus HBVC have a significant synergistic association with LD.
基金support from National Science Council of Chinese Taipei(Grant No.NSC 96-2625-Z-002-006-MY3)
文摘Numerical simulation has been widely applied to the assessment of debris flow hazards. In East Asia and especially Taiwan, the most widely used numerical programs are FLO-2D and Debris-aD. Although these two programs are applied to the same engineering tasks, they are different in many aspects. These two programs were compared according to their fundamental theories, input and output data, computational algorithms and results. Using both programs, the simulations of a real debris flow with abundant granular material induced by landslides at Xinfa village in southern Taiwan are performed for comparison. The simulation results show that Debris- 2D gives better assessment in hazard area delineating and flow depth predicting. Therefore, Debris-2D is better for simulation of granular debris flows.
文摘Floods have been popularly understood as the nightmares of human beings for their devastation causes. Floods in traditional Vietnamese minds are of the same type since ancient Vietnamese used a metaphor to address the floods in Red River Delta (Hanoi area) as un-auspicious marine spirit Thuy Tinh being defeated by the inland spirit Son Tinh in the legendary battle of life. Therefore, as being expressed in many cultures, floods are symbol of death and loss, and human beings have always attempted to get rich of or overcome the floods. However, the floods, under the awareness and pragmatic life of the people of An Giang Province as well as the whole Mekong River Delta (in Southern Vietnam), the floods are considered as the sign of wealth and happiness. What makes the floods to be so auspiciously acknowledged, and how do people manage to ~exploit" the floods to enrich their life? This paper is to investigate and generalize the approaches of utilizing the floods' resources to diversify their life, especially in cuisine culture. The research learns that the regularly stable floods in the Mekong River system strongly and positively affects the life of the local residents, and the community is further wise to exploit and transform the natural resources into their cultural world, mentally and materially, among which, ecotourism is a potentially prospective field
文摘It is difficult to manage the manufacturing hazardous waste (MHW) which is generated from a huge amount of compli- cated sources and causes very serious pollution. Therefore more and more attention has been paid to MHW pollution. Shanghai, as an industrial and economic center and an international metropolis in China, has a vast industrial system spanning a multitude of sectors, which generates MHW not only in a huge magnitude but also in a large variety of types from complicated sources, resulting in severe pollution. In 2003, the production of MHW in Shanghai is about 3.96 × 105 ton, involving 33 indices. Most of MHW in Shanghai is treated and disposed of, but a significant portion is not handled properly and effectively. This paper carries out in-field investigation on the current status of MHW production and treat- ment in Shanghai, and puts forward scientific proposals that Shanghai should facilitate cleaner production and minimize haz- ardous waste; strictly enforce hazardous waste registration system, strengthen monitoring the certified enterprises; strengthen intent disposal center construction and realize hazardous waste reclama- tion; accelerate establishing the technical criteria and the man- agement policy, promote the research and development on the treatment and disposal technology, and strengthen information management, thus realizing integrated management on MHW pollution.
基金Supported by the National Natural Science Foundation of China(10772029) the Ph.D Programs Foundation of Ministry of Education of China(20050007029) the Independent Research Subject of State Key Laboratory of Explosion Science and Technology(ZDKT08-02)
文摘In order to analyze the influence of vapor cloud shape on temperature field effect of unconfined vapor cloud explosion(UVCE)and obtain creditable prediction method of explosion temperature effect,the transient temperature fields of cylindrical and hemispherical UVCEs with same methane concentration and mass were numerically studied by computational fluid dynamics(CFD)technology.According to numerical simulation results, the concepts of UVCE’s temperature-near-field and temperature-far-field were proposed,the corresponding ranges were given,and the temperature attenuation laws and differences in corresponding regions with different vapor cloud shapes were presented.Through comparing with Baker fireball model,the accuracy and visualizability in acquisition of entire temperature effect based on numerical simulation were further validated.The functional relations among maximum temperature,horizontal distance,initial temperature and vapor cloud mass in temperature-near-field and temperature-far-field were deduced by means of data fitting,respectively.These conclusions provided quantitative basis for forecast and protection of UVCE disaster.
文摘Introduction of foreign plants and animals into Thailand's ecology has a long history, some arrived accidentally and others had a purpose. As global commerce increases, the issue of invasive alien species has become more urgent in Thailand. These agents are increasingly seen as a threat not only to biodiversity and ecosystem, but also to economic development and human well-being. They reduce yields of agricultural crops, forests and fisheries, decrease water availability, cause costly land degradation, block transport routes and contribute to the spread of disease. It is clear that since trade will not stop, dangerous alien species need to be controlled and managed and the strategies and control measures are to prevent, eradicate, contain, or effectively control the invaders. Implementation of these measures requires appropriate legislation, regulation and procedures. The impact of some invasive alien pests and their management on the agricultural sector of Thailand are presented.
文摘Objective The present retrospective study was to explore the clinical value of Six-Item Screener (SIS), which is constituted by 6 items from mini-mental status examination (MMSE), to identify cognitive impairment. Methods A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups: subjective memory complaints (SMCs) (475 cases), patients with mild cognitive impairment (MCI) (440 cases), and patients with Alzheimer's disease (AD) (1061 cases, including 555 mild, 339 moderate, and 167 severe). A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background. Results The cut-off of SIS score was 〈 2 for illiterate, 〈 3 for elementary, and 〈 4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%. Conclusion SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.
文摘OBJECTIVE: To establish an animal model of tractive spinal cord injury in rats in order to investigate its pathophysiological changes and clinical significance. METHODS: T(12)-L(3) spines were tracted longitudinally with a special spinal retractor that was put on the proccessus transverses of T(12)-L(3) vertebrae of the rat after exposing T(13)-L(2) spinal cord via dual laminectomy. At the same tine, the spinal cord function was monitored by cortical somatosensory evoked potential (CSEP). Rats were randomly divided into four groups according to the amplitude of CSEP P(1)-N(1) wave, the amount of the decreasing P(1)-N(1) wave was 30% (the 30% group), 50% (the 50% group) and 70% (the 70% group), respectively. After traction, the changes of the neural behavioral function in rats were observed and the morphological structure of the spinal cord was analyzed quantitatively with image analysis system of computer. RESULTS: With traction of spine, compared with the control group, the 30% group had no marked difference in combined behavioral score (CBS), neuron count, section area of neuron and Nissl body density, but the 50% and 70% groups had marked difference (P
基金supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2015BAI13B01)
文摘Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder(PTSD). PTSD is a fear-based disorder,characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However,the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory. This review discusses research that targeted extinction and reconsolidation to manipulate fear memory. Recent studies indicate that sleep is an active state that can regulate memory processes. We also discuss the influence of sleep on fear memory. For each manipulation, we briefly summarize the neural mechanisms that have been identified in human studies. Finally, we highlight potential limitations and future directions in the field to better translate existing interventions to clinical settings.
基金partly supported by National Natural Science Foundation of China (Grant No. 10971015, 11131002)Key Project of Chinese Ministry of Education (Grant No. 309007)the Fundamental Research Funds for the Central Universities
文摘This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and tumorigenicity experiments (Keiding, 1991; Sun, 2006) and several approaches have been proposed for the additive hazards model with univariate current status data (Linet M., 1998; Martinussen and Scheike, 2002). For bivariate data, in addition to facing the same problems as those with univariate data, one needs to deal with the association or correlation between two related failure time variables of interest. For this, we employ the copula model and an efficient estimation procedure is developed for inference. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. An illustrative example is provided.
基金Research is supported by the National Natural Science Foundation of China (11271260), Shanghai Leading Academic Discipline Project (No. XTKX2012), the Hujiang Foundation of China (B14005) and the Innovation Program of Shanghai Municipal Education Committee (13ZZ116).
文摘In this paper, a pest control model with state-dependent impulses is firstly established, which relies on releasing of natural enemies, together with spraying pesticides. By using the successor function of differential equation geometry rules, the existence of order one periodic solution is discussed. According to the Analogue of Poincare's Criterion, the orbitally asymptotic stability of the order one periodic solution is obtained. Furthermore, we investigated the global attractor of the system. From a biological point of view, our results indicate that: (1) the pest population can be controlled below some threshold; (2) compared to single measure, it is more efficient to take two measures for reducing the level of the pests.
基金supported by the National Basic Research Program (973) of China (No.2010CB126200)China Postdoctoral Science Foundation Project (No.20090451437)
文摘Detection of crop health conditions plays an important role in making control strategies of crop disease and insect damage and gaining high-quality production at late growth stages. In this study, hyperspectral reflectance of rice panicles was measured at the visible and near-infrared regions. The panicles were divided into three groups according to health conditions: healthy panicles, empty panicles caused by Nilaparvata lugens St^l, and panicles infected with Ustilaginoidea virens. Low order derivative spectra, namely, the first and second orders, were obtained using different techniques. Principal component analysis (PCA) was performed to obtain the principal component spectra (PCS) of the foregoing derivative and raw spectra to reduce the reflectance spectral dimension. Support vector classification (SVC) was employed to discriminate the healthy, empty, and infected panicles, with the front three PCS as the in- dependent variables. The overall accuracy and kappa coefficient were used to assess the classification accuracy of SVC. The overall accuracies of SVC with PCS derived from the raw, first, and second reflectance spectra for the testing dataset were 96.55%, 99.14%, and 96.55%, and the kappa coefficients were 94.81%, 98.71%, and 94.82%, respectively. Our results demonstrated that it is feasible to use visible and near-infrared spectroscopy to discriminate health conditions of rice panicles.
文摘Bats play important roles as pollen disseminators and pest predators.However,recent interest has focused on their role as natural reservoirs of pathogens associated with emerging infectious diseases.Prior to the outbreak of severe acute respiratory syndrome(SARS),about 60 bat virus species had been reported.The number of identified bat viruses has dramatically increased since the initial SARS outbreak,and most are putative novel virus species or genotypes.Serious infectious diseases caused by previously identified bat viruses continue to emerge throughout in Asia,Australia,Africa and America.Intriguingly,bats infected by these different viruses seldom display clinical symptoms of illness.The pathogenesis and potential threat of bat-borne viruses to public health remains largely unknown.This review provides a brief overview of bat viruses associated with emerging human infectious diseases.