The elderly represent a growing proportion of the overall population and household＇s heads in Cameroon. This demographic change has some impact on the economic and social situation of the latter, in particular, the f...The elderly represent a growing proportion of the overall population and household＇s heads in Cameroon. This demographic change has some impact on the economic and social situation of the latter, in particular, the functioning of the family structure and solidarity between generations. The successive crises （food and financial） coupled with structural adjustment programs have in fact worsened the problems of the elderly, without having for compensation, provided the corresponding benefits for other age groups. This study contributes to the analysis of changes over time in the family support system, especially with regard to household＇s heads aged in Cameroon. To achieve this, the discussion turns around three questions： （1） what is the extent and nature of the ageing in Cameroon？ （2） what are the demographic, economic, and social implications？ and （3） what is the impact of economic and social change on intergenerational relationships？ The data used come from the Population Census （1976, 1987, and 2005）, and the Cameroonian Household Survey of 2007. The gradual deterioration of the support system for the family, especially due to modernization, and the current and future numbers of older should bring more policymakers to meet the specific needs of this group in Cameroon.展开更多
Nuclear distribution gene C （NudC） was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 （Lisl）. NudC is conserved from fungi to mammals. Vertebrate...Nuclear distribution gene C （NudC） was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 （Lisl）. NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs： NudC, NudC-like protein （NudCL）, and NudC-like protein 2 （NudCL2）. All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 （Hsp90）. Our group and the others found that NudC homologs were involved in cell cycle regulation by stabilizing the components of the LIS l/dynein complex. Additionally, NudC plays important roles in cell migration, ciliogenesis, thrombopoiesis, and the in- flammatory response. It has been reported that NudCL is essential for the stability of the dynein intermediate chain and cilio- genesis via its interaction with the dynein 2 complex. Our data showed that NudCL2 regulates the LISl/dynein pathway by stabilizing LIS 1 with Hsp90 chaperone. The fourth distantly related member of the NudC family, CML66, a tumor-associated antigen in human leukemia, contains a p23 domain and appears to promote oncogenesis by regulating the IGF-1R-MAPK sig- naling pathway. In this review, we summarize our current knowledge of the NudC family and highlight its potential clinical relevance.展开更多
文摘The elderly represent a growing proportion of the overall population and household＇s heads in Cameroon. This demographic change has some impact on the economic and social situation of the latter, in particular, the functioning of the family structure and solidarity between generations. The successive crises （food and financial） coupled with structural adjustment programs have in fact worsened the problems of the elderly, without having for compensation, provided the corresponding benefits for other age groups. This study contributes to the analysis of changes over time in the family support system, especially with regard to household＇s heads aged in Cameroon. To achieve this, the discussion turns around three questions： （1） what is the extent and nature of the ageing in Cameroon？ （2） what are the demographic, economic, and social implications？ and （3） what is the impact of economic and social change on intergenerational relationships？ The data used come from the Population Census （1976, 1987, and 2005）, and the Cameroonian Household Survey of 2007. The gradual deterioration of the support system for the family, especially due to modernization, and the current and future numbers of older should bring more policymakers to meet the specific needs of this group in Cameroon.
基金supported by the Ministry of Science and Technology of China (2012CB945004, 2013CB945603)Natural Scientific Foundation of China (31125017, 31190063, 31100975, 31301149, 31471259)the 111 Project (B13026)
文摘Nuclear distribution gene C （NudC） was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 （Lisl）. NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs： NudC, NudC-like protein （NudCL）, and NudC-like protein 2 （NudCL2）. All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 （Hsp90）. Our group and the others found that NudC homologs were involved in cell cycle regulation by stabilizing the components of the LIS l/dynein complex. Additionally, NudC plays important roles in cell migration, ciliogenesis, thrombopoiesis, and the in- flammatory response. It has been reported that NudCL is essential for the stability of the dynein intermediate chain and cilio- genesis via its interaction with the dynein 2 complex. Our data showed that NudCL2 regulates the LISl/dynein pathway by stabilizing LIS 1 with Hsp90 chaperone. The fourth distantly related member of the NudC family, CML66, a tumor-associated antigen in human leukemia, contains a p23 domain and appears to promote oncogenesis by regulating the IGF-1R-MAPK sig- naling pathway. In this review, we summarize our current knowledge of the NudC family and highlight its potential clinical relevance.
