妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）是一种妊娠特发性疾病，常发生于妊娠中、晚期。 ICP临床特点是不明原因的皮肤瘙痒和肝功能异常，但产后迅速消失或恢复正常。严重时患者可表现为黄疸或者凝血功能...妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）是一种妊娠特发性疾病，常发生于妊娠中、晚期。 ICP临床特点是不明原因的皮肤瘙痒和肝功能异常，但产后迅速消失或恢复正常。严重时患者可表现为黄疸或者凝血功能异常等临床表征[1]。研究表明，ICP的发病有显著的家族性特征，并且不同地域的发病率也有显著的差异[2]。展开更多
We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because ex...We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because extirpation of an osteoma of the left temporo-occipital region was made 10 years ago. Restorative procto-colectomy and ileal pouch anal anastomosis was made but histology delineated adenocarcinoma of the rectum (Dukes C stage). We conclude that cranial osteomas often precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome and such patients should be evaluated with genetic testing followed by colonoscopy if results are positive to prevent the development of colorectal carcinoma. If the diagnosis is positive all family members should be evaluated for familial adenomatous polyposis.展开更多
文摘妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）是一种妊娠特发性疾病，常发生于妊娠中、晚期。 ICP临床特点是不明原因的皮肤瘙痒和肝功能异常，但产后迅速消失或恢复正常。严重时患者可表现为黄疸或者凝血功能异常等临床表征[1]。研究表明，ICP的发病有显著的家族性特征，并且不同地域的发病率也有显著的差异[2]。
文摘We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because extirpation of an osteoma of the left temporo-occipital region was made 10 years ago. Restorative procto-colectomy and ileal pouch anal anastomosis was made but histology delineated adenocarcinoma of the rectum (Dukes C stage). We conclude that cranial osteomas often precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome and such patients should be evaluated with genetic testing followed by colonoscopy if results are positive to prevent the development of colorectal carcinoma. If the diagnosis is positive all family members should be evaluated for familial adenomatous polyposis.
