To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families thr...To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families through the population -based Salisbury Eye Evaluation study. Subjects underwent noncycloplegic refrac tion if best-corrected visual acuity (BCVA) was ≤20/40, had lensometry to meas ure their currently worn spectacles if BCVA was > 20/40 with spectacles, or were considered to be plano (refraction of zero) if the BCVA was > 20/40 without spe ctacles. Preoperative refraction from medical records was used for bilaterally p seudophakic subjects. Utilizing hyperopia cutoffs from 1.00 to 2.50 diopters, ag e-, race-, and gender-ad-justed odds ratios for hyperopia with an affected s ibling ranged from 2.72 (95%confidence interval [CI], 1.84-4.01) to 4.87 (95 % CI, 2.54-9.30). The odds of hyperopia increased with age until 75 years, after which they remained relatively constant. Black men were significantly less likel y to be hyperopic than white men, white women, or black women. Hyperopia appears to be under strong genetic control in this older population.展开更多
遗传易感基因可使乳腺癌的患病风险增加5％～10％。乳腺癌遗传易感基因1／2（breast cancer sus-ceptibility gene 1／2，BRCA1／2）是已经发现的乳腺癌高外显率遗传易感基因，与29％～81％的遗传性乳腺癌发病有关。然而在乳腺癌高发的...遗传易感基因可使乳腺癌的患病风险增加5％～10％。乳腺癌遗传易感基因1／2（breast cancer sus-ceptibility gene 1／2，BRCA1／2）是已经发现的乳腺癌高外显率遗传易感基因，与29％～81％的遗传性乳腺癌发病有关。然而在乳腺癌高发的西方国家，仍然存在5％～50％的遗传性乳腺癌的家族聚集现象无法用BRCA1／2突变来解释口。。很多乳腺癌的家族聚集现象与BRCA1／2突变无关。根据目前的研究和文献报道，可能存在其他低外显率的基因突变调控乳腺癌的遗传易感性.展开更多
文摘To determine whether hyperopia aggregates in families in an older mixed-race population. Cross-sectional familial aggregation study using sibships. We recru ited 759 subjects (mean age, 73.4 years) in 241 families through the population -based Salisbury Eye Evaluation study. Subjects underwent noncycloplegic refrac tion if best-corrected visual acuity (BCVA) was ≤20/40, had lensometry to meas ure their currently worn spectacles if BCVA was > 20/40 with spectacles, or were considered to be plano (refraction of zero) if the BCVA was > 20/40 without spe ctacles. Preoperative refraction from medical records was used for bilaterally p seudophakic subjects. Utilizing hyperopia cutoffs from 1.00 to 2.50 diopters, ag e-, race-, and gender-ad-justed odds ratios for hyperopia with an affected s ibling ranged from 2.72 (95%confidence interval [CI], 1.84-4.01) to 4.87 (95 % CI, 2.54-9.30). The odds of hyperopia increased with age until 75 years, after which they remained relatively constant. Black men were significantly less likel y to be hyperopic than white men, white women, or black women. Hyperopia appears to be under strong genetic control in this older population.
文摘遗传易感基因可使乳腺癌的患病风险增加5％～10％。乳腺癌遗传易感基因1／2（breast cancer sus-ceptibility gene 1／2，BRCA1／2）是已经发现的乳腺癌高外显率遗传易感基因，与29％～81％的遗传性乳腺癌发病有关。然而在乳腺癌高发的西方国家，仍然存在5％～50％的遗传性乳腺癌的家族聚集现象无法用BRCA1／2突变来解释口。。很多乳腺癌的家族聚集现象与BRCA1／2突变无关。根据目前的研究和文献报道，可能存在其他低外显率的基因突变调控乳腺癌的遗传易感性.
