含溴结构域蛋白7(bromodomain-containing protein 7,BRD7)是含溴结构域蛋白家族成员之一,该类蛋白因含有高度保守的溴区结构域得名[1]。BRD7通过参与信号依赖的基因转录过程从而广泛参与并调控细胞增殖、分化、迁移、乏氧及凋亡等过程[...含溴结构域蛋白7(bromodomain-containing protein 7,BRD7)是含溴结构域蛋白家族成员之一,该类蛋白因含有高度保守的溴区结构域得名[1]。BRD7通过参与信号依赖的基因转录过程从而广泛参与并调控细胞增殖、分化、迁移、乏氧及凋亡等过程[2-4]。编码BRD7蛋白的相关基因是由余鹰等[5]在鼻咽癌的活检组织标本中通过cDNA差异分析法克隆得到的一个基因。展开更多
乳腺癌耐药蛋白属于三磷酸腺苷结合转运蛋白G超家族成员2(ATP-binding cassette superfamily G member 2, ABCG2),其作为药物排出泵,可以降低细胞内药物的浓度,保护细胞免受有毒物质的侵害.它保护正常细胞,但同时使肿瘤细胞对各种抗肿...乳腺癌耐药蛋白属于三磷酸腺苷结合转运蛋白G超家族成员2(ATP-binding cassette superfamily G member 2, ABCG2),其作为药物排出泵,可以降低细胞内药物的浓度,保护细胞免受有毒物质的侵害.它保护正常细胞,但同时使肿瘤细胞对各种抗肿瘤药物产生耐药性,影响化疗效果.本文综述ABCG2的生理功能、表达影响因素以及与消化道肿瘤的关系与作用,为消化道肿瘤的临床基础研究提供参考.展开更多
Objective. The aim of the study was to estimate the prevalence of hereditary cancers and the need for surveillance in Telemark county, Norway. Material and methods. All persons attending the Norwegian Colorectal Cance...Objective. The aim of the study was to estimate the prevalence of hereditary cancers and the need for surveillance in Telemark county, Norway. Material and methods. All persons attending the Norwegian Colorectal Cancer Prevention (NORCCAP) trial in Telemark were interviewed about cases of cancer in the family. Diagnoses were verified, pedigrees constructed and families classified according to preset criteria aiming at identifying hereditary cancer. Mutation analyses were performed in kindreds at risk for breast cancers when possible. Immunohistochemistry of tumors in assumed inherited colorectal cancer families was undertaken. Results. The screening examination was attended by 7224 persons among whom 2866 had cancer in the family. Of these, 2479 had no suspicion of any known inherited cancer syndrome. Family information questionnaires were mailed to 387 persons and returned by 191. Sixty-four of these 191 met the clinical criteria for familial cancer by family history after verification of diagnoses. Observed prevalences for being at risk for hereditary breast and breast-ovarian cancer (HBOC) or hereditary non-polyposis colorectal cancer (HNPCC) were 2.8‰and 0.77‰, respectively. Conclusions. The number of colonos-copies and mammograms obtained per year serving those who needed them was limited and reduced by clinical genetic work-up from 2866 with a family history of cancer to 64 proven cases. Continued surveillance of an unnecessarily high number leads to unjustified cancer worry, is costly and uses up health-care facilities. Genetic work-up is a one-time job that reduces input numbers to surveillance programs, provides a starting-point for mutation testing and is economically cost beneficial if inherited cancers are prevented or cured by the health-care programs offered.展开更多
文摘含溴结构域蛋白7(bromodomain-containing protein 7,BRD7)是含溴结构域蛋白家族成员之一,该类蛋白因含有高度保守的溴区结构域得名[1]。BRD7通过参与信号依赖的基因转录过程从而广泛参与并调控细胞增殖、分化、迁移、乏氧及凋亡等过程[2-4]。编码BRD7蛋白的相关基因是由余鹰等[5]在鼻咽癌的活检组织标本中通过cDNA差异分析法克隆得到的一个基因。
文摘乳腺癌耐药蛋白属于三磷酸腺苷结合转运蛋白G超家族成员2(ATP-binding cassette superfamily G member 2, ABCG2),其作为药物排出泵,可以降低细胞内药物的浓度,保护细胞免受有毒物质的侵害.它保护正常细胞,但同时使肿瘤细胞对各种抗肿瘤药物产生耐药性,影响化疗效果.本文综述ABCG2的生理功能、表达影响因素以及与消化道肿瘤的关系与作用,为消化道肿瘤的临床基础研究提供参考.
文摘Objective. The aim of the study was to estimate the prevalence of hereditary cancers and the need for surveillance in Telemark county, Norway. Material and methods. All persons attending the Norwegian Colorectal Cancer Prevention (NORCCAP) trial in Telemark were interviewed about cases of cancer in the family. Diagnoses were verified, pedigrees constructed and families classified according to preset criteria aiming at identifying hereditary cancer. Mutation analyses were performed in kindreds at risk for breast cancers when possible. Immunohistochemistry of tumors in assumed inherited colorectal cancer families was undertaken. Results. The screening examination was attended by 7224 persons among whom 2866 had cancer in the family. Of these, 2479 had no suspicion of any known inherited cancer syndrome. Family information questionnaires were mailed to 387 persons and returned by 191. Sixty-four of these 191 met the clinical criteria for familial cancer by family history after verification of diagnoses. Observed prevalences for being at risk for hereditary breast and breast-ovarian cancer (HBOC) or hereditary non-polyposis colorectal cancer (HNPCC) were 2.8‰and 0.77‰, respectively. Conclusions. The number of colonos-copies and mammograms obtained per year serving those who needed them was limited and reduced by clinical genetic work-up from 2866 with a family history of cancer to 64 proven cases. Continued surveillance of an unnecessarily high number leads to unjustified cancer worry, is costly and uses up health-care facilities. Genetic work-up is a one-time job that reduces input numbers to surveillance programs, provides a starting-point for mutation testing and is economically cost beneficial if inherited cancers are prevented or cured by the health-care programs offered.
