无论何种病因，肝脏疾病的进展都受到宿主遗传因素、病原体和其他环境因素间相互作用的影响［1］。营养状态也是其中之一，必需氨基酸蛋氨酸及其活性代谢物 S-腺苷蛋氨酸（SAMe）与肝病进展也相关［2］。有证据表明慢性肝病中会出现SAMe...无论何种病因，肝脏疾病的进展都受到宿主遗传因素、病原体和其他环境因素间相互作用的影响［1］。营养状态也是其中之一，必需氨基酸蛋氨酸及其活性代谢物 S-腺苷蛋氨酸（SAMe）与肝病进展也相关［2］。有证据表明慢性肝病中会出现SAMe 耗竭，SAMe 也曾被用于治疗某些疾病状态［3］。由于前期研究取得了一些鼓舞人心的结果但缺乏有效替代药物，在东欧、俄罗斯、中国、南亚和南美等国家和地区广泛采用 SAMe 治疗慢性肝病和肝内胆汁淤积。因此，有必要对 SAMe 在慢性肝病发病机制中的作用进行讨论，并认真回顾补充 SAMe 临床价值的证据。展开更多
乙型肝炎病毒（hepatitis B virus,HBV）感染是引起肝脏疾病最主要的原因之一。据估计,全球有20亿人曾感染过HBV,3.5亿~4亿人为HBV慢性感染者,其中75%的感染者为亚洲人[1]。乙型肝炎（乙肝）疫苗是预防HBV感染最有效的手段,但首次全程...乙型肝炎病毒（hepatitis B virus,HBV）感染是引起肝脏疾病最主要的原因之一。据估计,全球有20亿人曾感染过HBV,3.5亿~4亿人为HBV慢性感染者,其中75%的感染者为亚洲人[1]。乙型肝炎（乙肝）疫苗是预防HBV感染最有效的手段,但首次全程接种乙肝疫苗后,仍有5%~10%的人群HBV表面抗体（抗-HBs）达不到保护水平（抗-HBs〈10mIU/ml）[2-3]。展开更多
Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori（H pylori） is regarded a...Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori（H pylori） is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of Hpylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.展开更多
文摘无论何种病因，肝脏疾病的进展都受到宿主遗传因素、病原体和其他环境因素间相互作用的影响［1］。营养状态也是其中之一，必需氨基酸蛋氨酸及其活性代谢物 S-腺苷蛋氨酸（SAMe）与肝病进展也相关［2］。有证据表明慢性肝病中会出现SAMe 耗竭，SAMe 也曾被用于治疗某些疾病状态［3］。由于前期研究取得了一些鼓舞人心的结果但缺乏有效替代药物，在东欧、俄罗斯、中国、南亚和南美等国家和地区广泛采用 SAMe 治疗慢性肝病和肝内胆汁淤积。因此，有必要对 SAMe 在慢性肝病发病机制中的作用进行讨论，并认真回顾补充 SAMe 临床价值的证据。
文摘乙型肝炎病毒（hepatitis B virus,HBV）感染是引起肝脏疾病最主要的原因之一。据估计,全球有20亿人曾感染过HBV,3.5亿~4亿人为HBV慢性感染者,其中75%的感染者为亚洲人[1]。乙型肝炎（乙肝）疫苗是预防HBV感染最有效的手段,但首次全程接种乙肝疫苗后,仍有5%~10%的人群HBV表面抗体（抗-HBs）达不到保护水平（抗-HBs〈10mIU/ml）[2-3]。
文摘Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori（H pylori） is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of Hpylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.
