The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 ad...The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 adducts have an excellent efficiency in eliminating superoxide radical generated from auto oxidation of pyrogallol. At a mass concentration level of 150 μg/mL for β alanine C 60 adducts, the radical scavenging efficiency is approximately equivalent to one enzyme unit, in vitro experiments show that β alanine C 60 adducts can enhance the activity of mouse thymus cells and prolong their life time span. It reveals the potential use of these β alanine C 60 adducts as the novel potent free radical scavengers in biological systems.展开更多
Four gemini cationic surfactants were synthesized by N alkylation reaction of N,N dimethyl dodecyl amine with 1,2 ethanediol dichloracetate, 1,3 propanediol dichloracetate, 1,4 butanediol dichloracetate and 1,6 hexane...Four gemini cationic surfactants were synthesized by N alkylation reaction of N,N dimethyl dodecyl amine with 1,2 ethanediol dichloracetate, 1,3 propanediol dichloracetate, 1,4 butanediol dichloracetate and 1,6 hexanediol dichloracetate, respectively. The molecular structures of the surfactants were characterized by IR and 1H NMR spectra. The cmc values of gemini cationic surfactants SAA1, SAA2, SAA3, SAA4 were 0 91, 0 34, 0 35 and 0 78 mmol/L, respectively, much lower than that of the corresponding conventional single tailed surfactant [C 12 H 25 N(CH 3) 2CH 2 COOC 2H 5] +Cl -, whose cmc is 8 9 mmol/L. Their foaming capacity was 162, 171, 160, 168 mm, respectively , higher than 157 mm for [C 12 H 25 N(CH 3) 2CH 2COOC 2H 5] +Cl -.展开更多
Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxida...Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxidant activity of these C 60 adducts as the quencher for superoxide anion radical O -· 2 was evaluated by chemiluminescence in the system of pyrogallol-luminol. The results indicate that the three C 60 derivatives are all excellent quencher for superoxide anion radical O -· 2. The concentrations of 50% inhibition are 252, 140, 112 μmol/L respectively. This high efficiency should be attributed to many factors such as the numbers of remaining double bonds, donor effect of amino group and steric effect. However, the above results also suggest the effect of the adducted β-alanine groups is predominated in this system.展开更多
文摘The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 adducts have an excellent efficiency in eliminating superoxide radical generated from auto oxidation of pyrogallol. At a mass concentration level of 150 μg/mL for β alanine C 60 adducts, the radical scavenging efficiency is approximately equivalent to one enzyme unit, in vitro experiments show that β alanine C 60 adducts can enhance the activity of mouse thymus cells and prolong their life time span. It reveals the potential use of these β alanine C 60 adducts as the novel potent free radical scavengers in biological systems.
文摘Four gemini cationic surfactants were synthesized by N alkylation reaction of N,N dimethyl dodecyl amine with 1,2 ethanediol dichloracetate, 1,3 propanediol dichloracetate, 1,4 butanediol dichloracetate and 1,6 hexanediol dichloracetate, respectively. The molecular structures of the surfactants were characterized by IR and 1H NMR spectra. The cmc values of gemini cationic surfactants SAA1, SAA2, SAA3, SAA4 were 0 91, 0 34, 0 35 and 0 78 mmol/L, respectively, much lower than that of the corresponding conventional single tailed surfactant [C 12 H 25 N(CH 3) 2CH 2 COOC 2H 5] +Cl -, whose cmc is 8 9 mmol/L. Their foaming capacity was 162, 171, 160, 168 mm, respectively , higher than 157 mm for [C 12 H 25 N(CH 3) 2CH 2COOC 2H 5] +Cl -.
文摘Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxidant activity of these C 60 adducts as the quencher for superoxide anion radical O -· 2 was evaluated by chemiluminescence in the system of pyrogallol-luminol. The results indicate that the three C 60 derivatives are all excellent quencher for superoxide anion radical O -· 2. The concentrations of 50% inhibition are 252, 140, 112 μmol/L respectively. This high efficiency should be attributed to many factors such as the numbers of remaining double bonds, donor effect of amino group and steric effect. However, the above results also suggest the effect of the adducted β-alanine groups is predominated in this system.
