This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 react...This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 reactive optic nerve head astrocytes(ONHAs)by hypertensions and 26 normal controls,were integrated and deeply analyzed.Differentially expressed genes(DEGs)were sorted and candidate genes and pathways enrichment were analyzed.DEGs-associated protein-protein interaction network(PPI)was performed.Results A total of 119 consistently expressed genes were identified from 281 commonly changed DEGs,including 68 up-regulated genes and 51 down-regulated genes.PPI network complex filtered 75 DEGs(43 up-regulated and 32 down-regulated genes)of the 119 consistently altered DEGs and developed 117 edges,and 10 hub genes were identified.The most significant 3 modules were filtered from PPI,pathway enrichment analysis showed that module 1 was associated with extracellular exosome.Module 2 was mainly associated with antibody-dependent cellular cytotoxicity(ADCC)and module 3 was mainly associated with Hippo signaling pathway.Conclusion Taken above,using integrated bioinformatical analysis,we have identified DEGs candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension,which could improve our understanding of the cause and underlying molecular events,and these candidate genes and pathways could be therapeutic targets for glaucoma.展开更多
The Maputo Development Corridor along the N4 toll road between the north-eastern provinces of South Africa and Maputo （the capital and main port of Mozambique） was initiated in 1996. A Development Corridor can be se...The Maputo Development Corridor along the N4 toll road between the north-eastern provinces of South Africa and Maputo （the capital and main port of Mozambique） was initiated in 1996. A Development Corridor can be seen as a concept to elevate an area to a certain level of development. One of the objectives of this project was investment in transport infrastructure in order to create an enabling environment for economic growth and development. The project is also in line with the 1995 Spatial Development Initiatives of the South African Government that attempt to improve investment in those areas were the greatest potential for growth exists. This paper addresses economic wealth creation within the broader region that the N4 toll road and the corridor currently serve. The research revealed that the areas closer to the N4 corridor had higher growth in terms of economic output as measured by Gross Valued Added than those further removed. There were a stronger correlation between growth in employment and proximity to the road corridor for the manufacturing, construction, trade and transport sectors. Analysis done also shows that income per capita has grown at a faster rate in areas closer to the corridor that areas further removed.展开更多
基金support from the China National Natural Science Foundation Funding Project(NO.81804150)Hunan University of Chinese Medicine,National Key Discipline of TCM Diagnostics Foundation Funding Project(No.2015ZYZD02)+5 种基金The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese MedicineHunan Provincial Department of Education Innovation Platform Open Fund Project(16K065)Chinese Medicine Key Laboratory of Prevention and Treatment of Disease in Hunan Province(2017TP1018)Changsha Science and Technology Plan Project(KC1704005)Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese MedicineHunan Provincial Research Innovation Project for Graduate students(CX2017B426)
文摘This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 reactive optic nerve head astrocytes(ONHAs)by hypertensions and 26 normal controls,were integrated and deeply analyzed.Differentially expressed genes(DEGs)were sorted and candidate genes and pathways enrichment were analyzed.DEGs-associated protein-protein interaction network(PPI)was performed.Results A total of 119 consistently expressed genes were identified from 281 commonly changed DEGs,including 68 up-regulated genes and 51 down-regulated genes.PPI network complex filtered 75 DEGs(43 up-regulated and 32 down-regulated genes)of the 119 consistently altered DEGs and developed 117 edges,and 10 hub genes were identified.The most significant 3 modules were filtered from PPI,pathway enrichment analysis showed that module 1 was associated with extracellular exosome.Module 2 was mainly associated with antibody-dependent cellular cytotoxicity(ADCC)and module 3 was mainly associated with Hippo signaling pathway.Conclusion Taken above,using integrated bioinformatical analysis,we have identified DEGs candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension,which could improve our understanding of the cause and underlying molecular events,and these candidate genes and pathways could be therapeutic targets for glaucoma.
文摘The Maputo Development Corridor along the N4 toll road between the north-eastern provinces of South Africa and Maputo （the capital and main port of Mozambique） was initiated in 1996. A Development Corridor can be seen as a concept to elevate an area to a certain level of development. One of the objectives of this project was investment in transport infrastructure in order to create an enabling environment for economic growth and development. The project is also in line with the 1995 Spatial Development Initiatives of the South African Government that attempt to improve investment in those areas were the greatest potential for growth exists. This paper addresses economic wealth creation within the broader region that the N4 toll road and the corridor currently serve. The research revealed that the areas closer to the N4 corridor had higher growth in terms of economic output as measured by Gross Valued Added than those further removed. There were a stronger correlation between growth in employment and proximity to the road corridor for the manufacturing, construction, trade and transport sectors. Analysis done also shows that income per capita has grown at a faster rate in areas closer to the corridor that areas further removed.
