尽管深度神经网络在很多任务上取得了良好的结果,但是它们对于微小的对抗扰动却很容易出现预测错误.然而在人体姿态估计的对抗攻击任务中,通常需要添加较大的扰动噪声才能攻击成功,这使得其不可察性变差;减少扰动噪声又会削弱攻击效果....尽管深度神经网络在很多任务上取得了良好的结果,但是它们对于微小的对抗扰动却很容易出现预测错误.然而在人体姿态估计的对抗攻击任务中,通常需要添加较大的扰动噪声才能攻击成功,这使得其不可察性变差;减少扰动噪声又会削弱攻击效果.为了克服该矛盾,提出一种面向人体姿态估计的两阶段局部对抗攻击方法.所提方法首先通过预攻击估计出扰动关键区域,然后利用不可察性约束在关键区域内生成扰动.方法不仅可以对人体姿态进行有效攻击,而且还能确保最终扰动区域具有低可察性.采用COCO2017作为对抗扰动实验数据集并使用PCK(percentage of correct keypoints)作为评价指标,比较在人体姿态估计模型中IGSM和C&W方法的攻击效果,其PCK降低值分别提高了15.4%与2.8%.实验结果表明所提方法在保证攻击的低可察的同时,能够取得较好的攻击效果.展开更多
This paper describes the experience of Jilin oilfield trials for Microbial Enhanced Oil Recovery (MEOR). A new technique to identify microbes with DNA for MEOR has been established, and useful microbes selected f...This paper describes the experience of Jilin oilfield trials for Microbial Enhanced Oil Recovery (MEOR). A new technique to identify microbes with DNA for MEOR has been established, and useful microbes selected for use in field trials. Behaviors of bacteria activated in the reservoir, oil recovery and water cut, and the viscosity of crude oil produced through huff & puff testing and flooding with molasses-injection tests, have been investigated in situ. CJF-002, which produces biopolysaccharide, is the best among the microbes used for field trials, as it can use molasses as nutrient and produce a small quantity of CO2 and a mass of water-insoluble biopolymer. The metabolic behavior in the reservoir showed that CJF-002 had a good potentiality for MEOR.展开更多
[Objective] The aim was to research the genetic mechanism of barley male sterility, and provide the theoretical reference for breeding strong heterosis hybrid of barley. [ Method] Fertility segregation phenomenon, mor...[Objective] The aim was to research the genetic mechanism of barley male sterility, and provide the theoretical reference for breeding strong heterosis hybrid of barley. [ Method] Fertility segregation phenomenon, morphological characteristics and main agronomic characters of male sterility character of 4 kinds of barley male sterility materials 2001 - 17, 2001 - 37, 2001 - 84 and 2001 - 116 and their dedved lines were observed and researched.[ Result] Barley male sterility existed genetic phenomenon of single dominant nuclear gene caused by environmental stimulation, its sterility controlled by MS, the sterile genotype was MSms. There was stable nucleo-cytoplasmic inheritance on barley male sterility which was controlled by cytoplasmic mate sterile gene S and nuclear gene rr, and its genotype was S(rr), this male sterility belonged to CMS type sterility. Temperature had no effect on fertility. [ Conclusion] There was stable nucleo-cytoplasmic inheritance on barley male sterility, this result played a positively promoting role in barley practical production.展开更多
TiAl alloys were produced by investment casting method combined with induction skull melting (ISM) technique. In situ scanning electron microscopy (SEM) was utilized to study the fracture characteristics and crack...TiAl alloys were produced by investment casting method combined with induction skull melting (ISM) technique. In situ scanning electron microscopy (SEM) was utilized to study the fracture characteristics and crack propagation of a notched investment cast TiAl specimens in tension under incremental loading conditions. The whole process of crack initiation, propagation and failure during tensile deformation was observed and characterized. The results show that the fracture mechanism was sensitive to not only the microcracks near the notched area but also lamellar orientation to loading axis. The high tensile stress leads to the new microcracks nucleate along lamellar interfaces of grains with favorable orientation when local stress intensity reaches the toughness threshold of the material. Thus, both plasticity and high tensile stress are required to cause notched TiAl failure.展开更多
A new type of nonlinear observer for nonlinear systems is presented. Instead of approximating thc cntire nonlinear system with the neural network (NN), only the un-modeled part left over after the lincarization is a...A new type of nonlinear observer for nonlinear systems is presented. Instead of approximating thc cntire nonlinear system with the neural network (NN), only the un-modeled part left over after the lincarization is approximated. Compared with the conventional linear observer, the observer provides more accurate estimation of the state. The state estimation error is proved to asymptotically approach zero with the Lyapunov method. The simulation result shows that the proposed observer scheme is effective and has a potential application ability in the fault detection and identification (FDI), and the state estimation.展开更多
[Objective] The aim was to study characters of pollen grains of tetraploid lines and diploid control line of Chrysanthemum cinerariifolium (Trev.) Vis.,morphological characters,fertility of pollen grain and germinatio...[Objective] The aim was to study characters of pollen grains of tetraploid lines and diploid control line of Chrysanthemum cinerariifolium (Trev.) Vis.,morphological characters,fertility of pollen grain and germination percentage of seeds. [Method] Pollen grains were prepared by sulphuric acid-acetyl oxide decomposition method. The lengths of polar axis and equatorial axis of pollen grains were determined with general optical microscope. The morphology of pollen grains was observed with SEM (scanning electron microscope) and the typical visual fields of 2 500× (or 2 000×),7 000× were taken pictures. [Result] Comparing with the diploid control line,the pollen grains of five tetraploid lines which were tested were different from the diploid line in morphology,sculpture,etc.. 4 of the 5 tested samples were significant larger than the diploid line in size and one was similar to the diploid line. [Conclusion] This research provided references for breeding tetraploid improved varieties of Chrysanthemum cinerariifolium (Trev.) Vis. with good fertility and high germination percentage.展开更多
[ Objective] The aim of this study was to lay a foundation for obtaining effective traditional Chinese medicine preparations controlling chicken colibacillosis. [ Method] With the western medicine Lomeflbxacin Hydroch...[ Objective] The aim of this study was to lay a foundation for obtaining effective traditional Chinese medicine preparations controlling chicken colibacillosis. [ Method] With the western medicine Lomeflbxacin Hydrochloride and Sodium Chloride Injection as the control, drug sensitivity tests of 15 single traditional Chinese herbs and seven self-made Chinese herbal compounds were conducted. Subsequently, the single traditional Chinese herbs presenting good in vitro antibacterial effects against Escherichia coli and all the seven compounds were given to the chicks artificially infected with E. coil to observe their efficacies. [ Result] The results of drug sensitivity tests showed that all the 15 traditional Chinese herbs had certain antibacterial effect against E. coli, among which aloe, pomegranate rind and radix sanguisorbae were the best. Compound 1, 2 and 5 had good antibacterial effects in vitro. By in vivo test, traditional Chinese medicines showed superior efficacies on infected chicks than western medicine, and compound 1 and 2 performed well. [ConclusiOn] Traditional Chinese medicine preparations are good at controlling Chicken colibacillosis, but their bacteriostasis mechanism in vivo was different with that in vitro.展开更多
A stochastic optimal control strategy for partially observable nonlinear quasi Hamiltonian systems is proposed. The optimal control forces consist of two parts. The first part is determined by the conditions under whi...A stochastic optimal control strategy for partially observable nonlinear quasi Hamiltonian systems is proposed. The optimal control forces consist of two parts. The first part is determined by the conditions under which the stochastic optimal control problem of a partially observable nonlinear system is converted into that of a completely observable linear system. The second part is determined by solving the dynamical programming equation derived by applying the stochastic averaging method and stochastic dynamical programming principle to the completely observable linear control system. The response of the optimally controlled quasi Hamiltonian system is predicted by solving the averaged Fokker-Planck-Kolmogorov equation associated with the optimally controlled completely observable linear system and solving the Riccati equation for the estimated error of system states. An example is given to illustrate the procedure and effectiveness of the proposed control strategy.展开更多
The evolution of precipitates and mechanical properties of AZ80A magnesium alloy with aging time was studied by in situ observation with SEM,TEM and tensile testing.The results show that the continuous precipitation(C...The evolution of precipitates and mechanical properties of AZ80A magnesium alloy with aging time was studied by in situ observation with SEM,TEM and tensile testing.The results show that the continuous precipitation(CP)phases near the reaction front(RF)are replaced by the discontinuous precipitation(DP)phases at the early aging stage.In DP regions,the elliptical phases coarsen obviously with the increase of aging time,which results in a slightly slow reduction of the intracrystalline hardness of DP regions.In CP regions,some small plate phases reprecipitate simultaneously with the growth of the initial precipitates,which contributes to a slight increase in the intracrystalline hardness in CP regions at the later aging stage.The aging hardening of DP regions is faster and stronger than that of CP regions.However,the age strengthening of CP regions not only compensates for the overaging softening of DP regions but also improves the strength of the alloy.展开更多
Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and...Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and 21 males, with a median age 62 years (35–82 years), 13 of whom were treated with pemetrexed only and the left 37 cases were treated with pemetrexed combined with platinum in the Department of Oncology, Renmin Hospital of Wuhan University from June 2006 to March 2009. Single agent regimen: patients received pemetrexed 500 mg/m2 on day 1 with every 21 days. Combination regimen: patients received pemetrexed 500 mg/m2 on day 1 and carboplatin 300 mg/m2 on day 1 or cisplatin 35 mg/m2 on day 1 to day 3 or nedaplatin 80 mg/m2 on day 1 by intravenous infusion with 21 days as one cycle. RECIST 1.0 standard was used to evaluate the clinical efficiency, and the WHO toxicity standard was used to evaluate toxic reaction, and the QOL was used to evaluate the quality of life. Results: All patients were given 162 cycles (at least 2 cycles, at most 6 cycles) and the response rate of all the patients were evaluated. There were 2 complete remission (CR), 7 partial remission (PR), 22 stable disease (SD) and 19 progressive disease (PD) in the group, the overall response rate was (RR) was 18.0% and disease control rate (DCR) 62.0%. The quality of life improvement rate reaches 58.0%. The major toxic reaction included neutropenia, thrombocytopenia, hypemia, nausea, and vomiting. Most of the severity of these effects was grade I–II and well tolerated. Conclusion: Chemotherapy with pemetrexed or pemetrexed combined with platinum in the treatment of advanced non-small cell lung cancer is effective, safe and well-tolerable, which can improve quality of life of the patient.展开更多
The state space representations of fractional order linear time- invariant(LTI) systems are introduced, and their solution formulas are deduced hy means of Laplace transform. The stability condition of fractional or...The state space representations of fractional order linear time- invariant(LTI) systems are introduced, and their solution formulas are deduced hy means of Laplace transform. The stability condition of fractional order LTI systems is given, and its proof is deduced by means of using linear non - singularity transform and the derivative property of Mittag-Leffler function. The controllability condition of fractional m'der LTI systems is given, and its proof is deduced by means of using its characteristic polynomial and the Cayley-Hamilton theorem. The observability condition of fractional order LTI systems is given, and its proof is deduced by means of their solution formulas. Finally an example is given to prove the correctness of the stability, controllability, and observability conditions mentioned above, s are deduced by means of Laplace transform. Their stability, controllability and observability conditions are given as well as their proofs.展开更多
Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with ...Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with malignant hydrothorax were randomly divided into two groups.Observation group was 31 examples,thoracic cavity injection IL-2 and Cisplatin;31 cases in control group using Cisplatin alone intra-thoracic injection.The regime of every week for 1–4 weeks was used to observe short term effects and complications.Results: The total response rate in observe group was higher than that in control group (90.3% vs.68.1%),which had statistically significant difference (P < 0.05).The complications included gastrointestinal tract reaction,bone marrow inhibition,chest pain and fever.The incidence rates of chest pain and fever in observe group was slightly higher than that in control group,but there was no statistically significant difference (P > 0.05).Conclusion: The IL-2 combining with Cisplatin intra-thoracic injection for malignant hydrothorax has the features of good therapeutic effects and slight poisonous side effects,which is worth to be used in clinic.展开更多
A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and af...A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and after PEHA loading were characterized by X-ray powder diffraction,N2adsorption/desorption,thermal gravimetric analysis and scanning electron microscope to investigate the textural and thermo-physical properties.CO2adsorption performance was evaluated in a fixed bed adsorption system.Results indicated that the structure of MCM-41 was preserved after loading PEHA.Surface area and total pore volume of PEHA loaded MCM-41 decreased with the increase of loading.The working adsorption capacity of CO2could be significantly improved at 60%of PEHA loading and 75°C.The effect of the height of adsorbent bed was investigated and the best working adsorption capacity for MCM-41-PEHA-60 reached 165 mg·(g adsorbent)-1at 75°C.Adsorption/desorption circle showed that the CO2working adsorption capacity of MCM-41-PEHA kept stable.展开更多
Sewage source heat pump unit operates under partial load most of the time, and study on the law of coefficient of performance (COP) of the unit varying with load ratio can provide basis for the heat pump units running...Sewage source heat pump unit operates under partial load most of the time, and study on the law of coefficient of performance (COP) of the unit varying with load ratio can provide basis for the heat pump units running in high efficiency. A mathematical model determining COP, evaporation temperature and condensation temperature of a single unit was proposed. Under the condition of uniform load distribution, the model was established according to different ways of bearing partial load with the same type multi...展开更多
AIM: To investigate the hepatoprotective effect of MK615, a Japanese apricot extract, in an animal model, and its clinical therapeutic effect. METHODS: Wistar rats were administered physiologi- cal saline (4 mL/kg...AIM: To investigate the hepatoprotective effect of MK615, a Japanese apricot extract, in an animal model, and its clinical therapeutic effect. METHODS: Wistar rats were administered physiologi- cal saline (4 mL/kg) or MK615 solution (4 mL/kg) for 7 d. On the sixth d, acute hepatic injury was induced by administering a single intraperitoneal injection (ip) of D-galactosamine hydrochloride (D-GaIN) (600 mg/kg). Plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined, and liver tissues were used for histopathological analy- sis. Fifty-eight patients with liver disorders [hepatitis C (n = 40), non-alcoholic fatty liver disease (n = 15), and autoimmune liver disease (n = 3)] were orally admin- istered commercially available Misatol ME-containing MK615 (13 g/d) daily for 12 wk. Blood and urine were sampled immediately before and 6 wk, 12 wk, and 16 wk after the start of intake to measure various bio- chemical parameters. The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint. RESULTS: D-GaIN effectively induced acute hepatic injury in the rats. At 48 h after the ip injection of D-GaIN, the plasma levels of ALT (475.6 :t: 191.5 IU/L vs 225.3 + 194.2 IU/L, P 〈 0.05) and AST (1253.9:1:223.4 IU/L vs 621.9 + 478.2 IU/L, P 〈 0.05) in the MK615 group were significantly lower than the control group. Scattered single cell necrosis, loss of hepatocytes, and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group. However, these findings were less pronounced in the group receiving MK615. At the end of the clinical study, serum ALT and AST levels were significantly de- creased compared with pre-intake baseline levels from 103.5 :l: 58.8 IU/L to 71.8 + 39.3 IU/L (P 〈 0.05) and from 93.5 :E 55.6 IU/L to 65.5 + 34.8 IU/L (P 〈 0.05), respectively. A reduction of 〉~ 30% from the pre-study baseline ALT level was observed in 26 (45%) of the 58 patients, while 25 (43%) patients exhibited similar AST level reductions. The chronic hepatitis C group exhibit- ed significant ALT and AST level reductions from 93.4:1: 51.1 IU/L to 64.6 + 35.1 IU/L (P 〈 0.05) and from 94.2 + 55.5 IU/L to 67.2:1:35.6 IU/L (P 〈 0.05), respective- ly. A reduction of 〉~ 30% from the pre-study baseline ALT level was observed in 20 (50%) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid (UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration. MK615 protected hepatocytes from D-GaiN-induced cytotoxicity in rats. Misatol ME decreased elevated ALT and AST levels in patients with liver disorders. CONCLUSION: These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders.展开更多
PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were random...PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were randomly divided into the treatment group and control group, and the changes in serum T3, T4 and TSH contents in different weeks were investigated. RESULTS: Serum T3, T4 and TSH contents in the treatment group all were higher than those in the control group, with statistically significant differences in the contents of T4 and TSH in the second week and T3 content in the fourth week (P展开更多
Objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO). Methods: Clinical data were re...Objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO). Methods: Clinical data were retrospectively analyzed in 26 carcinoma patients complicated with MBO, in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, China, from March 2007 to April 2009. All 26 carcinoma patients with MBO were divided into no groups: the controlling group (CG, routine therapy, 15 patients) and the octreotide group (OG, 11 patients). The octreotide group received routine therapy combined with octreotide (0.3 mg/d) by 24 hours continuously subcutaneous octreotide infusion. The changes of curative effectiveness related to symptoms, the times of recovering exsufflation and defecation, the average drain of gastrointestinal drainage tube, the duration of gastrointestinal drainage tube and the rate of extubation, were observed and compared between the two groups. Results: After treatment, remarkable changing rates of MBO related symptoms were 81.8% (9/11) in OG, and 46.7% (7/15) in CG (P 〈 0.05). The 78% of SG and 30% of CG recovered the exsufflation and defecation, and the mean times they needed were 3.2 d and 5.8 d, respectively (P 〈 0.05). The durations of gastrointestinal drainage tube of OG and CG were (5 ± 1.2) d and (10 ±2.3) d, respectively, and the rates of extubation were 54.5% and 20%, respectively. The improvement rate in the octreotide group was better than that in the controlling group and the difference was significant (72.7% and 26.7%, P 〈 0.05). Conclusion; The administration of octreotide in combination with routine treatment can be very effective in the treatment of MBO. It can relieve the symptoms of MBO effectively and improve the quality of life of the end-stage patients. It has provided one kind of new treating thought and method for treatment of malignant bowel obstruction.展开更多
Presents a novel approach for the sensor fault diagnosis of time-delay systems by using an adaptive observer technique. The sensor tault is modeled as an additive perturbation described by a time varying function. Sys...Presents a novel approach for the sensor fault diagnosis of time-delay systems by using an adaptive observer technique. The sensor tault is modeled as an additive perturbation described by a time varying function. Systems without model uncertainty are initially considered, followed by a discussion of a general situation where the system is subjected to either model uncertainty or external disturbance. An adaptive diagnostic algorithm is developed to diagnose the fault, and a modified version is proposed for general system to improve robusiness. The stability of fault diagnosis system is proved. Finally, a numerical example is given to illustrate the efficiency of the proposed method.展开更多
文摘尽管深度神经网络在很多任务上取得了良好的结果,但是它们对于微小的对抗扰动却很容易出现预测错误.然而在人体姿态估计的对抗攻击任务中,通常需要添加较大的扰动噪声才能攻击成功,这使得其不可察性变差;减少扰动噪声又会削弱攻击效果.为了克服该矛盾,提出一种面向人体姿态估计的两阶段局部对抗攻击方法.所提方法首先通过预攻击估计出扰动关键区域,然后利用不可察性约束在关键区域内生成扰动.方法不仅可以对人体姿态进行有效攻击,而且还能确保最终扰动区域具有低可察性.采用COCO2017作为对抗扰动实验数据集并使用PCK(percentage of correct keypoints)作为评价指标,比较在人体姿态估计模型中IGSM和C&W方法的攻击效果,其PCK降低值分别提高了15.4%与2.8%.实验结果表明所提方法在保证攻击的低可察的同时,能够取得较好的攻击效果.
文摘This paper describes the experience of Jilin oilfield trials for Microbial Enhanced Oil Recovery (MEOR). A new technique to identify microbes with DNA for MEOR has been established, and useful microbes selected for use in field trials. Behaviors of bacteria activated in the reservoir, oil recovery and water cut, and the viscosity of crude oil produced through huff & puff testing and flooding with molasses-injection tests, have been investigated in situ. CJF-002, which produces biopolysaccharide, is the best among the microbes used for field trials, as it can use molasses as nutrient and produce a small quantity of CO2 and a mass of water-insoluble biopolymer. The metabolic behavior in the reservoir showed that CJF-002 had a good potentiality for MEOR.
基金Supported by National Natural Science Foundation of Inner Mongolia(200711020307)Public Industry ( Agriculture)Specific Re-search Program of Ministry of Agriculture (nyhyzx07-010)~~
文摘[Objective] The aim was to research the genetic mechanism of barley male sterility, and provide the theoretical reference for breeding strong heterosis hybrid of barley. [ Method] Fertility segregation phenomenon, morphological characteristics and main agronomic characters of male sterility character of 4 kinds of barley male sterility materials 2001 - 17, 2001 - 37, 2001 - 84 and 2001 - 116 and their dedved lines were observed and researched.[ Result] Barley male sterility existed genetic phenomenon of single dominant nuclear gene caused by environmental stimulation, its sterility controlled by MS, the sterile genotype was MSms. There was stable nucleo-cytoplasmic inheritance on barley male sterility which was controlled by cytoplasmic mate sterile gene S and nuclear gene rr, and its genotype was S(rr), this male sterility belonged to CMS type sterility. Temperature had no effect on fertility. [ Conclusion] There was stable nucleo-cytoplasmic inheritance on barley male sterility, this result played a positively promoting role in barley practical production.
基金Project(51001040)supported by the National Natural Science Foundation of ChinaProject(200802130014)supported by Specialized Research Fund for the Doctoral Program of Higher Education,China+1 种基金Project(HIT.NSRIF.2010116)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(HITQNJS 2009022)supported by Development Program for Outstanding Young Teachers in Harbin Institute of Technology
文摘TiAl alloys were produced by investment casting method combined with induction skull melting (ISM) technique. In situ scanning electron microscopy (SEM) was utilized to study the fracture characteristics and crack propagation of a notched investment cast TiAl specimens in tension under incremental loading conditions. The whole process of crack initiation, propagation and failure during tensile deformation was observed and characterized. The results show that the fracture mechanism was sensitive to not only the microcracks near the notched area but also lamellar orientation to loading axis. The high tensile stress leads to the new microcracks nucleate along lamellar interfaces of grains with favorable orientation when local stress intensity reaches the toughness threshold of the material. Thus, both plasticity and high tensile stress are required to cause notched TiAl failure.
文摘A new type of nonlinear observer for nonlinear systems is presented. Instead of approximating thc cntire nonlinear system with the neural network (NN), only the un-modeled part left over after the lincarization is approximated. Compared with the conventional linear observer, the observer provides more accurate estimation of the state. The state estimation error is proved to asymptotically approach zero with the Lyapunov method. The simulation result shows that the proposed observer scheme is effective and has a potential application ability in the fault detection and identification (FDI), and the state estimation.
基金Supported by the Fundamental Research Funds for the Central Universities (SWJTU09BR221)~~
文摘[Objective] The aim was to study characters of pollen grains of tetraploid lines and diploid control line of Chrysanthemum cinerariifolium (Trev.) Vis.,morphological characters,fertility of pollen grain and germination percentage of seeds. [Method] Pollen grains were prepared by sulphuric acid-acetyl oxide decomposition method. The lengths of polar axis and equatorial axis of pollen grains were determined with general optical microscope. The morphology of pollen grains was observed with SEM (scanning electron microscope) and the typical visual fields of 2 500× (or 2 000×),7 000× were taken pictures. [Result] Comparing with the diploid control line,the pollen grains of five tetraploid lines which were tested were different from the diploid line in morphology,sculpture,etc.. 4 of the 5 tested samples were significant larger than the diploid line in size and one was similar to the diploid line. [Conclusion] This research provided references for breeding tetraploid improved varieties of Chrysanthemum cinerariifolium (Trev.) Vis. with good fertility and high germination percentage.
基金Supported by Fund of Education Department in Hebei Province(2007408)~~
文摘[ Objective] The aim of this study was to lay a foundation for obtaining effective traditional Chinese medicine preparations controlling chicken colibacillosis. [ Method] With the western medicine Lomeflbxacin Hydrochloride and Sodium Chloride Injection as the control, drug sensitivity tests of 15 single traditional Chinese herbs and seven self-made Chinese herbal compounds were conducted. Subsequently, the single traditional Chinese herbs presenting good in vitro antibacterial effects against Escherichia coli and all the seven compounds were given to the chicks artificially infected with E. coil to observe their efficacies. [ Result] The results of drug sensitivity tests showed that all the 15 traditional Chinese herbs had certain antibacterial effect against E. coli, among which aloe, pomegranate rind and radix sanguisorbae were the best. Compound 1, 2 and 5 had good antibacterial effects in vitro. By in vivo test, traditional Chinese medicines showed superior efficacies on infected chicks than western medicine, and compound 1 and 2 performed well. [ConclusiOn] Traditional Chinese medicine preparations are good at controlling Chicken colibacillosis, but their bacteriostasis mechanism in vivo was different with that in vitro.
基金Project supported by the National Natural Science Foundation ofChina (No. 10332030), the Special Fund for Doctor Programs inInstitutions of Higher Learning of China (No. 20020335092), andthe Zhejiang Provincial Natural Science Foundation (No. 101046),China
文摘A stochastic optimal control strategy for partially observable nonlinear quasi Hamiltonian systems is proposed. The optimal control forces consist of two parts. The first part is determined by the conditions under which the stochastic optimal control problem of a partially observable nonlinear system is converted into that of a completely observable linear system. The second part is determined by solving the dynamical programming equation derived by applying the stochastic averaging method and stochastic dynamical programming principle to the completely observable linear control system. The response of the optimally controlled quasi Hamiltonian system is predicted by solving the averaged Fokker-Planck-Kolmogorov equation associated with the optimally controlled completely observable linear system and solving the Riccati equation for the estimated error of system states. An example is given to illustrate the procedure and effectiveness of the proposed control strategy.
基金financially supported by the Natural Science Foundation of Hunan Province, China (No. 2018JJ2503)the Postgraduate Independent Exploration and Innovation Project of Central South University, China (No. 1053320171111)
文摘The evolution of precipitates and mechanical properties of AZ80A magnesium alloy with aging time was studied by in situ observation with SEM,TEM and tensile testing.The results show that the continuous precipitation(CP)phases near the reaction front(RF)are replaced by the discontinuous precipitation(DP)phases at the early aging stage.In DP regions,the elliptical phases coarsen obviously with the increase of aging time,which results in a slightly slow reduction of the intracrystalline hardness of DP regions.In CP regions,some small plate phases reprecipitate simultaneously with the growth of the initial precipitates,which contributes to a slight increase in the intracrystalline hardness in CP regions at the later aging stage.The aging hardening of DP regions is faster and stronger than that of CP regions.However,the age strengthening of CP regions not only compensates for the overaging softening of DP regions but also improves the strength of the alloy.
文摘Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and 21 males, with a median age 62 years (35–82 years), 13 of whom were treated with pemetrexed only and the left 37 cases were treated with pemetrexed combined with platinum in the Department of Oncology, Renmin Hospital of Wuhan University from June 2006 to March 2009. Single agent regimen: patients received pemetrexed 500 mg/m2 on day 1 with every 21 days. Combination regimen: patients received pemetrexed 500 mg/m2 on day 1 and carboplatin 300 mg/m2 on day 1 or cisplatin 35 mg/m2 on day 1 to day 3 or nedaplatin 80 mg/m2 on day 1 by intravenous infusion with 21 days as one cycle. RECIST 1.0 standard was used to evaluate the clinical efficiency, and the WHO toxicity standard was used to evaluate toxic reaction, and the QOL was used to evaluate the quality of life. Results: All patients were given 162 cycles (at least 2 cycles, at most 6 cycles) and the response rate of all the patients were evaluated. There were 2 complete remission (CR), 7 partial remission (PR), 22 stable disease (SD) and 19 progressive disease (PD) in the group, the overall response rate was (RR) was 18.0% and disease control rate (DCR) 62.0%. The quality of life improvement rate reaches 58.0%. The major toxic reaction included neutropenia, thrombocytopenia, hypemia, nausea, and vomiting. Most of the severity of these effects was grade I–II and well tolerated. Conclusion: Chemotherapy with pemetrexed or pemetrexed combined with platinum in the treatment of advanced non-small cell lung cancer is effective, safe and well-tolerable, which can improve quality of life of the patient.
基金stability, coSponsored by the National High Technology Research and Development Program of China (Grant No.2003AA517020), the National Natural Science Foundation of China (Grant No.50206012), and Developing Fund of Shanghai Science Committee (Grant No.011607033).
文摘The state space representations of fractional order linear time- invariant(LTI) systems are introduced, and their solution formulas are deduced hy means of Laplace transform. The stability condition of fractional order LTI systems is given, and its proof is deduced by means of using linear non - singularity transform and the derivative property of Mittag-Leffler function. The controllability condition of fractional m'der LTI systems is given, and its proof is deduced by means of using its characteristic polynomial and the Cayley-Hamilton theorem. The observability condition of fractional order LTI systems is given, and its proof is deduced by means of their solution formulas. Finally an example is given to prove the correctness of the stability, controllability, and observability conditions mentioned above, s are deduced by means of Laplace transform. Their stability, controllability and observability conditions are given as well as their proofs.
文摘Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with malignant hydrothorax were randomly divided into two groups.Observation group was 31 examples,thoracic cavity injection IL-2 and Cisplatin;31 cases in control group using Cisplatin alone intra-thoracic injection.The regime of every week for 1–4 weeks was used to observe short term effects and complications.Results: The total response rate in observe group was higher than that in control group (90.3% vs.68.1%),which had statistically significant difference (P < 0.05).The complications included gastrointestinal tract reaction,bone marrow inhibition,chest pain and fever.The incidence rates of chest pain and fever in observe group was slightly higher than that in control group,but there was no statistically significant difference (P > 0.05).Conclusion: The IL-2 combining with Cisplatin intra-thoracic injection for malignant hydrothorax has the features of good therapeutic effects and slight poisonous side effects,which is worth to be used in clinic.
基金Supported by the National Natural Science Foundation of China(20836008,21176132)the Special Research Fund for the Doctoral Program of the Ministry of Education of China(20101012174)
文摘A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and after PEHA loading were characterized by X-ray powder diffraction,N2adsorption/desorption,thermal gravimetric analysis and scanning electron microscope to investigate the textural and thermo-physical properties.CO2adsorption performance was evaluated in a fixed bed adsorption system.Results indicated that the structure of MCM-41 was preserved after loading PEHA.Surface area and total pore volume of PEHA loaded MCM-41 decreased with the increase of loading.The working adsorption capacity of CO2could be significantly improved at 60%of PEHA loading and 75°C.The effect of the height of adsorbent bed was investigated and the best working adsorption capacity for MCM-41-PEHA-60 reached 165 mg·(g adsorbent)-1at 75°C.Adsorption/desorption circle showed that the CO2working adsorption capacity of MCM-41-PEHA kept stable.
基金Supported by National Natural Science Foundation of China (No. 50578048)"Heating, Gas, Ventilation and Air Conditioning" Key Laboratory Open Subject in Beijing (No. KF200710)the Postdoctoral Researcher Science Foundation of China (No. 20090450986)
文摘Sewage source heat pump unit operates under partial load most of the time, and study on the law of coefficient of performance (COP) of the unit varying with load ratio can provide basis for the heat pump units running in high efficiency. A mathematical model determining COP, evaporation temperature and condensation temperature of a single unit was proposed. Under the condition of uniform load distribution, the model was established according to different ways of bearing partial load with the same type multi...
文摘AIM: To investigate the hepatoprotective effect of MK615, a Japanese apricot extract, in an animal model, and its clinical therapeutic effect. METHODS: Wistar rats were administered physiologi- cal saline (4 mL/kg) or MK615 solution (4 mL/kg) for 7 d. On the sixth d, acute hepatic injury was induced by administering a single intraperitoneal injection (ip) of D-galactosamine hydrochloride (D-GaIN) (600 mg/kg). Plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined, and liver tissues were used for histopathological analy- sis. Fifty-eight patients with liver disorders [hepatitis C (n = 40), non-alcoholic fatty liver disease (n = 15), and autoimmune liver disease (n = 3)] were orally admin- istered commercially available Misatol ME-containing MK615 (13 g/d) daily for 12 wk. Blood and urine were sampled immediately before and 6 wk, 12 wk, and 16 wk after the start of intake to measure various bio- chemical parameters. The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint. RESULTS: D-GaIN effectively induced acute hepatic injury in the rats. At 48 h after the ip injection of D-GaIN, the plasma levels of ALT (475.6 :t: 191.5 IU/L vs 225.3 + 194.2 IU/L, P 〈 0.05) and AST (1253.9:1:223.4 IU/L vs 621.9 + 478.2 IU/L, P 〈 0.05) in the MK615 group were significantly lower than the control group. Scattered single cell necrosis, loss of hepatocytes, and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group. However, these findings were less pronounced in the group receiving MK615. At the end of the clinical study, serum ALT and AST levels were significantly de- creased compared with pre-intake baseline levels from 103.5 :l: 58.8 IU/L to 71.8 + 39.3 IU/L (P 〈 0.05) and from 93.5 :E 55.6 IU/L to 65.5 + 34.8 IU/L (P 〈 0.05), respectively. A reduction of 〉~ 30% from the pre-study baseline ALT level was observed in 26 (45%) of the 58 patients, while 25 (43%) patients exhibited similar AST level reductions. The chronic hepatitis C group exhibit- ed significant ALT and AST level reductions from 93.4:1: 51.1 IU/L to 64.6 + 35.1 IU/L (P 〈 0.05) and from 94.2 + 55.5 IU/L to 67.2:1:35.6 IU/L (P 〈 0.05), respective- ly. A reduction of 〉~ 30% from the pre-study baseline ALT level was observed in 20 (50%) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid (UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration. MK615 protected hepatocytes from D-GaiN-induced cytotoxicity in rats. Misatol ME decreased elevated ALT and AST levels in patients with liver disorders. CONCLUSION: These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders.
文摘PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were randomly divided into the treatment group and control group, and the changes in serum T3, T4 and TSH contents in different weeks were investigated. RESULTS: Serum T3, T4 and TSH contents in the treatment group all were higher than those in the control group, with statistically significant differences in the contents of T4 and TSH in the second week and T3 content in the fourth week (P
文摘Objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO). Methods: Clinical data were retrospectively analyzed in 26 carcinoma patients complicated with MBO, in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, China, from March 2007 to April 2009. All 26 carcinoma patients with MBO were divided into no groups: the controlling group (CG, routine therapy, 15 patients) and the octreotide group (OG, 11 patients). The octreotide group received routine therapy combined with octreotide (0.3 mg/d) by 24 hours continuously subcutaneous octreotide infusion. The changes of curative effectiveness related to symptoms, the times of recovering exsufflation and defecation, the average drain of gastrointestinal drainage tube, the duration of gastrointestinal drainage tube and the rate of extubation, were observed and compared between the two groups. Results: After treatment, remarkable changing rates of MBO related symptoms were 81.8% (9/11) in OG, and 46.7% (7/15) in CG (P 〈 0.05). The 78% of SG and 30% of CG recovered the exsufflation and defecation, and the mean times they needed were 3.2 d and 5.8 d, respectively (P 〈 0.05). The durations of gastrointestinal drainage tube of OG and CG were (5 ± 1.2) d and (10 ±2.3) d, respectively, and the rates of extubation were 54.5% and 20%, respectively. The improvement rate in the octreotide group was better than that in the controlling group and the difference was significant (72.7% and 26.7%, P 〈 0.05). Conclusion; The administration of octreotide in combination with routine treatment can be very effective in the treatment of MBO. It can relieve the symptoms of MBO effectively and improve the quality of life of the end-stage patients. It has provided one kind of new treating thought and method for treatment of malignant bowel obstruction.
基金Sponsored by the National Natural Science Foundation of China (Grant No.60274058).
文摘Presents a novel approach for the sensor fault diagnosis of time-delay systems by using an adaptive observer technique. The sensor tault is modeled as an additive perturbation described by a time varying function. Systems without model uncertainty are initially considered, followed by a discussion of a general situation where the system is subjected to either model uncertainty or external disturbance. An adaptive diagnostic algorithm is developed to diagnose the fault, and a modified version is proposed for general system to improve robusiness. The stability of fault diagnosis system is proved. Finally, a numerical example is given to illustrate the efficiency of the proposed method.