Objective: To identify lateralizing features during seizures in infants and as sess their reliability. Methods Infants were included if they had video EEG mon itoring at our institution, and were seizure free for at l...Objective: To identify lateralizing features during seizures in infants and as sess their reliability. Methods Infants were included if they had video EEG mon itoring at our institution, and were seizure free for at least 12 months after epilepsy surgery. Lateralizing signs and seizure symptomatology were classified based on blinded video review. Results We analyzed 100 seizures from 19 infants (1 to 32, mean 13 months of age) (1 to 14 seizures per patient). Potential later alizing signs were seen in 58 seizures from 12 infants, including unilateral clo nic jerking (8 patients); forced, sustained tonic version of the eyes to one sid e (7 patients); predominantly unilateral infantile spasms (5 patients); unilater al tonic stiffening of an arm and leg (2 patients); nystagmus (2 patients) and p ostictal hemiparesis (1 patient). Except for tonic eye version, each of the sign s was contralateral to the hemisphere of seizure onsetin all but one patient wh o had predominantly ipsilateral spasms and clonic arm activity. Tonic eye versio n was contralateral in 3 patients, ipsilateral in 1 patient, and toward either s ide in different seizures in 3 patients. Conclusion Reliable lateralizing signs included focal clonic activity and predominantly unilateral spasms. Focal tonic activity, nystagmus and postictal hemiparesis were also consistently contralater al but were observed only in few patients. Tonic eye version was unreliable and could not beused to lateralizeseizure onset. The sequence of eye and head version evolvi ng to generalized tonic clonic convulsions was not seen in this age group.展开更多
Mei symmetry and Mei conserved quantity for a non-holonomic system of non-Chetaev's type with unilateralconstraints in the Nielsen style are studied.The differential equations of motion for the system above are es...Mei symmetry and Mei conserved quantity for a non-holonomic system of non-Chetaev's type with unilateralconstraints in the Nielsen style are studied.The differential equations of motion for the system above are established.The definition and the criteria of Mei symmetry,conditions,and expressions of Mei conserved quantity deduced directlyfrom the Mei symmetry are given.An example is given to illustrate the application of the results.展开更多
Structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints are investigated. Appell equations and differential equations of motion for holonomi...Structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints are investigated. Appell equations and differential equations of motion for holonomie mechanic systems with unilateral constraints axe established. The definition and the criterion of Mei symmetry for Appell equations in holonomic systems with unilateral constraints under the infinitesimal transformations of groups axe also given. The expressions of the structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints expressed by Appell functions are obtained. An example is given to illustrate the application of the results.展开更多
In this paper, we study the Mei symmetry which can result in a Lutzky conserved quantity for nonholonomic mechanical system with unilateral constraints. The definition and the criterion of the Mei symmetry for the sys...In this paper, we study the Mei symmetry which can result in a Lutzky conserved quantity for nonholonomic mechanical system with unilateral constraints. The definition and the criterion of the Mei symmetry for the system are given. The necessary and sufficient condition under which the Mei symmetry is a Lie symmetry for the system is obtained. A Lutzky conserved quantity deduced from the Mei symmetry is gotten. An example is given to illustrate the application of our results.展开更多
目的:探讨乳腺癌易感基因(breast cancer susceptibility gene,BRCA)1和BRCA2突变对乳腺癌人群手术方式选择的影响。方法:研究对象为2017年12月—2021年6月在北京大学国际医院乳腺外科接受住院治疗的符合病例选择标准的130例乳腺癌患者...目的:探讨乳腺癌易感基因(breast cancer susceptibility gene,BRCA)1和BRCA2突变对乳腺癌人群手术方式选择的影响。方法:研究对象为2017年12月—2021年6月在北京大学国际医院乳腺外科接受住院治疗的符合病例选择标准的130例乳腺癌患者,均接受BRCA1/2基因检测及手术治疗。收集患者的临床病理资料,包括发病年龄、乳腺癌和(或)卵巢癌家族史、单侧或双侧乳腺癌、病理类型、组织学分级、肿瘤大小、免疫组织化学结果、治疗前腋窝淋巴结转移情况、是否接受新辅助化疗以及手术方式等。比较BRCA1/2致病胚系突变与非突变携带者的手术方式。结果:130例患者中,BRCA1/2致病胚系突变率为17.7%(23/130)。BRCA1/2致病胚系突变携带者与未携带者的手术方式存在显著差异(P<0.01)。与未携带BRCA1/2致病胚系突变的患者相比,23例BRCA1/2致病胚系突变携带者的保乳率较低(21.7%vs 50.5%),接受患侧单纯乳房切除术的比例较低(30.4%vs 49.5%),而接受患侧乳房全切术联合对侧预防性乳房切除术的比例高(47.8%vs 0.0%)。结论:BRCA1/2突变状态对乳腺癌患者的手术方式选择存在显著影响。BRCA1/2突变乳腺癌患者的保乳率低,并且接受患侧乳房全切术联合对侧预防性乳房切除术的比例高。展开更多
文摘Objective: To identify lateralizing features during seizures in infants and as sess their reliability. Methods Infants were included if they had video EEG mon itoring at our institution, and were seizure free for at least 12 months after epilepsy surgery. Lateralizing signs and seizure symptomatology were classified based on blinded video review. Results We analyzed 100 seizures from 19 infants (1 to 32, mean 13 months of age) (1 to 14 seizures per patient). Potential later alizing signs were seen in 58 seizures from 12 infants, including unilateral clo nic jerking (8 patients); forced, sustained tonic version of the eyes to one sid e (7 patients); predominantly unilateral infantile spasms (5 patients); unilater al tonic stiffening of an arm and leg (2 patients); nystagmus (2 patients) and p ostictal hemiparesis (1 patient). Except for tonic eye version, each of the sign s was contralateral to the hemisphere of seizure onsetin all but one patient wh o had predominantly ipsilateral spasms and clonic arm activity. Tonic eye versio n was contralateral in 3 patients, ipsilateral in 1 patient, and toward either s ide in different seizures in 3 patients. Conclusion Reliable lateralizing signs included focal clonic activity and predominantly unilateral spasms. Focal tonic activity, nystagmus and postictal hemiparesis were also consistently contralater al but were observed only in few patients. Tonic eye version was unreliable and could not beused to lateralizeseizure onset. The sequence of eye and head version evolvi ng to generalized tonic clonic convulsions was not seen in this age group.
基金Supported by the National Natural Science Foundation of China under Grant No.10572021Preparatory Research Foundation of Jiangnan under Grant No.2008LYY011
文摘Mei symmetry and Mei conserved quantity for a non-holonomic system of non-Chetaev's type with unilateralconstraints in the Nielsen style are studied.The differential equations of motion for the system above are established.The definition and the criteria of Mei symmetry,conditions,and expressions of Mei conserved quantity deduced directlyfrom the Mei symmetry are given.An example is given to illustrate the application of the results.
基金Supported by the National Natural Science Foundation of China under Grant No.10572021the Preparatory Research Foundation of Jiangnan University under Grant No.2008LYY011
文摘Structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints are investigated. Appell equations and differential equations of motion for holonomie mechanic systems with unilateral constraints axe established. The definition and the criterion of Mei symmetry for Appell equations in holonomic systems with unilateral constraints under the infinitesimal transformations of groups axe also given. The expressions of the structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints expressed by Appell functions are obtained. An example is given to illustrate the application of the results.
文摘In this paper, we study the Mei symmetry which can result in a Lutzky conserved quantity for nonholonomic mechanical system with unilateral constraints. The definition and the criterion of the Mei symmetry for the system are given. The necessary and sufficient condition under which the Mei symmetry is a Lie symmetry for the system is obtained. A Lutzky conserved quantity deduced from the Mei symmetry is gotten. An example is given to illustrate the application of our results.
