Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with prima...Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with primary brain tumou rs(PBT)for developing both PBT and the risk for other types of cancer.Al l PBT patients identified in Sweden f rom 1958-97in The Swedish Cancer Reg istry(SCR)were linked to the nationwide Swedish Fam ily Database,including persons in S weden born from 1932-97.The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer.S tandardised incidence ratios(SIR)were calculated using the incidence rates from SCR as the reference.We found that there were no increased risks for any specific type of PBT in the cohort of spouses.In the FDR cohort,generally the risk for a PBT was significantly increased by 2to 3times for the same h istopathology as the probands.Spouses of PBT patients had an increased risk of skin cancer.We conclude that FDR,not spouses,have a significantly increased risk,which indicates a genetic origin of the familial aggrega tion of brain展开更多
AIM: To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS: This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academ...AIM: To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS: This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academic, hospital-based endoscopy clinic. Patients included were: those undergoing esophagogastroduodenoscopy, colonoscopy or flexible sigmoidoscopy and patients who failed to appear were compared to a control group. The main outcome measure was a multivariate analysis of factors associated with truancy from scheduled endoscopic procedures. Factors analyzed included gender, age, waiting time, type of procedure, referring physician, distance to hospital, first or subsequent endoscopic procedure or encounter with gastroenterologist, and urgency of the procedure. RESULTS: Two hundred and thirty-four patients did not show up for their scheduled appointment. Compared to a control group, factors statistically significantly associated with truancy in the multivariate analysis were: non-urgent vs urgent procedure (OR 1.62, 95% CI 1.06, 2.450), referred by a specialist vs a family doctor (OR 2.76, 95% CI 1.31, 5.52) and office-based consult prior to endoscopy vs consult and endoscopic procedure during the same appointment (OR 2.24, 95% CI 1.33, 3.78). CONCLUSION: Identifying patients who are not scheduled for same-day consult and endoscopy, those referred by a specialist, and those with non-urgent referrals may help reduce patient truancy.展开更多
文摘Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with primary brain tumou rs(PBT)for developing both PBT and the risk for other types of cancer.Al l PBT patients identified in Sweden f rom 1958-97in The Swedish Cancer Reg istry(SCR)were linked to the nationwide Swedish Fam ily Database,including persons in S weden born from 1932-97.The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer.S tandardised incidence ratios(SIR)were calculated using the incidence rates from SCR as the reference.We found that there were no increased risks for any specific type of PBT in the cohort of spouses.In the FDR cohort,generally the risk for a PBT was significantly increased by 2to 3times for the same h istopathology as the probands.Spouses of PBT patients had an increased risk of skin cancer.We conclude that FDR,not spouses,have a significantly increased risk,which indicates a genetic origin of the familial aggrega tion of brain
文摘AIM: To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS: This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academic, hospital-based endoscopy clinic. Patients included were: those undergoing esophagogastroduodenoscopy, colonoscopy or flexible sigmoidoscopy and patients who failed to appear were compared to a control group. The main outcome measure was a multivariate analysis of factors associated with truancy from scheduled endoscopic procedures. Factors analyzed included gender, age, waiting time, type of procedure, referring physician, distance to hospital, first or subsequent endoscopic procedure or encounter with gastroenterologist, and urgency of the procedure. RESULTS: Two hundred and thirty-four patients did not show up for their scheduled appointment. Compared to a control group, factors statistically significantly associated with truancy in the multivariate analysis were: non-urgent vs urgent procedure (OR 1.62, 95% CI 1.06, 2.450), referred by a specialist vs a family doctor (OR 2.76, 95% CI 1.31, 5.52) and office-based consult prior to endoscopy vs consult and endoscopic procedure during the same appointment (OR 2.24, 95% CI 1.33, 3.78). CONCLUSION: Identifying patients who are not scheduled for same-day consult and endoscopy, those referred by a specialist, and those with non-urgent referrals may help reduce patient truancy.
