Synthesis,characterization and biological activity in vitro of FeCrAl(f)/HA asymmetrical biological functionally gradient materials

FeCrAl(f)/HA biological functionally gradient materials(FGMs) were successfully fabricated by the hot pressing technique.Scanning electron microscope(SEM),energy dispersive spectrometer(EDS) and bending strength test machine were utilized to characterize the microstructure,component,mechanical properties and the formation of the Ca-deficient apatite on the surface of these materials.The results indicate that an asymmetrical FeCrAl(f)/HA FGM,consolidating powders prepared by mixing HA with 3%–15%(volume fraction) is successfully prepared.Both of the matrix and FeCrAl fiber are integrated very tightly and bite into each other very deeply.And counter diffusion takes place to some extent in two phase interfaces.The elemental compositions of the FeCrAl(f)/HA FGM change progressively.Ca and P contents increase gradually with immersion time increasing,and thereafter approach equilibrium.The bone-like apatite layer forms on the materials surface,which possesses benign bioactivity,and the favorable biocompatibility can provide potential firm fixation between FeCrAl(f)/HA asymmetrical FGM implants and human bone.

Is It a Vain Hope That Museum Children Education Applies to All Children？ --A Research on the Classification and Age-group Division of Children

The museum education focusing on the children is different from adult acceptors for the mental development of the children presents obvious stage features. Therefore, a clear definition on the ages of the children in the service must be made. The children in different ages can find their own educational project groups in a short time according to their own categories and ages. To facilitate the branding of routine childhood education programs, improve the implementing benefit of childhood education programs and realize the maximization of resource utilization in the Museum Children Education, this study firstly generalizes and extracts one of the common problems that affect the implementing benefit of Chinese Museum Children Education project based on the case analysis - focus and age-group of service objects. Then this paper （article） explores it step by step. Finally the article combines the analyses with the empirical researches on feedback information acquired in on-site observations and semi-structured interviews, to propose improvement suggestions for the problem.

2^n＋2阶Mendelsohn三元系大集的构造

设X是一个v元集(v≥3)。X的一个循环三元组是由三个有序对(x,y),(y,z),(z,x)组成的一个集,其中x,y,z是X的不同元。我们记它为〈x,y,z〉或〈y,z,x〉或〈z,x,y〉。X上的一个Mendelsohn三元系是一个对子(X,B),其中B由X的若干循环三元组构成,使得X的每个(由不同元组成的)有序对恰在B的一个循环三元组中。我们记它为MTS(v)。已经知道MTS(v)存在当且仅当v≡0或1(mod3),v≥3 v≠6。

Influence of Accompanying Anions on Potassium Retention and Leaching in Potato Growing Alluvial Soils

A column study was carried out to assess the influence of accompanying anions on potassium （K） leaching at potato growing sites with different soil textures （sandy loam and clay loam） in northwestern India. Potassium was applied in the top 15 cm layer of soil column at 30 and 60 mg K kg-1 through different sources having different accompanying anions （CI-, SO^-, NO3 and H2PO4-）. Maximum K was retained in the top 0-15 cm layer with a sharp decrease in K content occurring in 15 30 cm layer of the soil column. The trend was similar for both levels of applied K as well as frequency of leaching and soil type. The decrease of K content in soil column after four leaching events was maximum in case of Khanaura sandy loam, while only minor decrease was observed in Hundowal clay loam when K was applied at 60 mg K kg-1, indicating higher potential of clay rich soil to adsorb K. In general, the K leaching in presence of the accompanying anions followed the order of SO4^2-≤ H2PO42- 〈 NO3 = Cl-. Highest 1 mol·L^-1 CH3COONH4-extractable K was retained when K was applied along with SO4^2- and H2PO4 anions, and the least was retained when accompanying anion was Cl-. The influence of anions was more pronounced in the light textured soil and at high amounts of K application. Higher levels of K application resulted in higher losses of K, especially in sandy loam soil as observed from the leachate concentration. Among the different K sources, the maximum amount of K leaching was noticed in the soil column amended with KC1. After four leachings, the maximum amount of K leached out was 6.40 mg L-1 in Hundowal clay loam and 9.29 mg L-1 in Khanaura sandy loam at 60 mg K kg-1 of soil application through KC1. These concentrations were lower than the recommended guideline of the World Health Organisation （12.00 mg L-1）.

Synthesis and molecular docking study of(E)-4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl-3-(4-chlorophenyl)acrylate as a JAK3 inhibitor

A 4-anilinoquinazoline derivative(1) designed as a JAK3 inhibitor was synthesized in high yield by a practical and efficient method.The molecular docking study was also performed to elucidate the molecular mechanism of the JAK3 inhibitory potency of compound 1.The results indicated that compound 1 had various interactions with the key amino acid residues at the ATP-binding cavity of JAK3 protein and presented high affinity to JAK3 protein,which was even higher than JANEX-1 and Tasocitinib.

Design, synthesis, insecticidal evaluation and molecular docking studies of cis-nitenpyram analogues bearing diglycine esters

Based on the strategies of receptor structure-guided neonicotinoid design, a series of novel cis-nitenpyram analogues bearing diglycine esters were designed and synthesized. Preliminary bioassays indicated that the insecticidal spectra of the target compounds were expanded compared with our previous work, while all the target compounds presented excellent insecticidal activities against Nilaparvata lugens and Aphis medicagini at 100 mg/L. Among these analogues, 6b showed 100% mortality against Nilaparvata lugens (LC 50 = 0.163 mg/L) and 90% against Aphis medicagini at 4 mg/L. SARs suggested that the insecticidal potency of our designed cis-nitenpyram analogues was dual-controlled by the size and species of the ester groups. The molecular docking simulations revealed that the structural uniqueness of these analogues may lead to a unique molecular recognition and binding mode compared with the previously designed compounds. Introduction of the peptide bond gave rise to more significant hydrogen bonds between the nitenpyram analogues bonding with the amino acid residues of insect nAChRs. The docking results explained the SARs observed in vitro, and shed light on the novel insecticidal mechanism of these cis-nitenpyram analogues.

Resolution of ghost imaging with entangled photons for different types of momentum correlation

We present an analytical analysis of the spatial resolution of quantum ghost imaging implemented by entangled photons from a general, spontaneously parametric, down-conversion process. We find that the resolution is affected by both the pump beam waist and the nonlinear crystal length. Hence, we determined a method to improve the resolution for a certain imaging setup. It should be noted that the resolution is not uniquely related to the degree of entanglement of the photon pair since the resolution can be optimized for a certain degree of entanglement. For certain types of Einstein-Podolsky-Rosen(EPR) states——namely the momentum-correlated or momentum-positively correlated states——the resolution exhibits a simpler relationship with the pump beam waist and crystal length. Further, a vivid numerical simulation of ghost imaging is presented for different types of EPR states,which supports our analysis. This work discusses applicable references to the applications of quantum ghost imaging.

Moduli spaces of model real submanifolds:Two alternative approaches

Abstract Instead of the invariant theory approach employed by Beloshapka and Mamai for constructing the moduli spaces of Beloshapka＇s universal Cauchy-Riemann （CR） models, we consider two alternative approaches borrowed from the theories of equivalence problem and Lie symmetries, each of which having its own advan- tages. Also the moduli space M（1, 4） associated to the class of universal CR models of CR dimension 1 and codimension 4 is computed by means of the presented methods.

Virus-like supramolecular assemblies formed by cooperation of base pairing interaction and peptidic association

A peptide nucleic acid （PNA）-peptide conjugated molecule, T＇3（AKAE）2, was designed to have both a PNA segment for oligo- nucleotide binding and an ionic self-complementary peptide sequence for self-association. T＇3（AKAE）2 could co-assemble with oligoadenines （d（A）x） to form virus-like supramolecular structures whose morphology showed dependence on the chain length and rigidity of the d（A）x molecules. Smaller nanospheres with diameters of 13.0±2.0 nm were produced in the case of d（A）6. Wormlike aggregates with lengths of 20-50 nm and diameters of 15.0±2.5 nm were found in the cases of d（A）12, d（A）ls, d（A）24 and d（A）30. And larger spherical aggregates with diameters of 18±5 nm came into presence in the cases of d（A）36 and d（A）42＋. These nanostructures were suggested to be formed under a cooperative effect of base pair recognition and peptidic association. The study provides insights into the programmed assembly of a multi-components system as well as control of the size and shade of the co-assembled structures, which is of great significance in develouing gene/drug deliverv systems.