在Pirkle型的 (S ,S) Whelk O 1与纤维素衍生物型的CDMPC两种手性柱上对六种外消旋萘普生酯进行了对映体分离 ,通过研究烷氧基结构上的差异以及流动相中不同的醇类添加剂对手性识别的影响 ,探讨和比较了外消旋萘普生酯在两种手性固定...在Pirkle型的 (S ,S) Whelk O 1与纤维素衍生物型的CDMPC两种手性柱上对六种外消旋萘普生酯进行了对映体分离 ,通过研究烷氧基结构上的差异以及流动相中不同的醇类添加剂对手性识别的影响 ,探讨和比较了外消旋萘普生酯在两种手性固定相上手性识别的机理 .对于 (S ,S) Whelk O 1,溶质与固定相之间的吸引作用是手性识别的主要因素 ,而对于CDMPC 。展开更多
Based on chiral ligand exchange, the distribution behavior of mandelic acid enantiomers in the two-phase system containing copper ion(Ⅱ)(Cu2+) and N-n-dedecane-L-hydroxyproline (L), was studied. At different pH, the ...Based on chiral ligand exchange, the distribution behavior of mandelic acid enantiomers in the two-phase system containing copper ion(Ⅱ)(Cu2+) and N-n-dedecane-L-hydroxyproline (L), was studied. At different pH, the partition of Cu2+ in the two-phase system containing N-n-dedecane-L-hydroxyproline, was investigated. The formation constant of binary cpmplex(Li2Cu) was obtained by regression. The influence of pH, concentrations of Cu2+ and chiral ligand, and solvents on partition coefficients(K) and separation factor(α), was discussed. The experimental results show that Li forms more stable ternary complex with D-mandelic acid than with L- mandelic acid. There is a large influence of pH on K and α. At low pH values (<3.5), formation of binary complexes is thermodynamically unfavourable. K and α are best when pH values are above 3.5 and the molar ratio of chiral ligand to Cu2+ is 2:1. At the same time, solvents influence K and α very much.展开更多
文摘在Pirkle型的 (S ,S) Whelk O 1与纤维素衍生物型的CDMPC两种手性柱上对六种外消旋萘普生酯进行了对映体分离 ,通过研究烷氧基结构上的差异以及流动相中不同的醇类添加剂对手性识别的影响 ,探讨和比较了外消旋萘普生酯在两种手性固定相上手性识别的机理 .对于 (S ,S) Whelk O 1,溶质与固定相之间的吸引作用是手性识别的主要因素 ,而对于CDMPC 。
文摘Based on chiral ligand exchange, the distribution behavior of mandelic acid enantiomers in the two-phase system containing copper ion(Ⅱ)(Cu2+) and N-n-dedecane-L-hydroxyproline (L), was studied. At different pH, the partition of Cu2+ in the two-phase system containing N-n-dedecane-L-hydroxyproline, was investigated. The formation constant of binary cpmplex(Li2Cu) was obtained by regression. The influence of pH, concentrations of Cu2+ and chiral ligand, and solvents on partition coefficients(K) and separation factor(α), was discussed. The experimental results show that Li forms more stable ternary complex with D-mandelic acid than with L- mandelic acid. There is a large influence of pH on K and α. At low pH values (<3.5), formation of binary complexes is thermodynamically unfavourable. K and α are best when pH values are above 3.5 and the molar ratio of chiral ligand to Cu2+ is 2:1. At the same time, solvents influence K and α very much.
