Asymmetric hydrogenation of α-keto Weinreb amides has been realized with [Ru（（S）-Sunphos）（benzene）C1]C1 as the catalyst and CeC13·7H20 as the additive. A series of enantiopure -hydroxy Weinreb amides （up ...Asymmetric hydrogenation of α-keto Weinreb amides has been realized with [Ru（（S）-Sunphos）（benzene）C1]C1 as the catalyst and CeC13·7H20 as the additive. A series of enantiopure -hydroxy Weinreb amides （up to 97% ee） have been obtained. Cata- lytic amount of CeC13·7H20 is essential for the high reactivity and enantioselectivity and the ratio of CeC13·7H20 to [Ru（（S）-Sunphos）（benzene）C1]C1 plays an important role in the hydrogenation reaction.展开更多
文摘Asymmetric hydrogenation of α-keto Weinreb amides has been realized with [Ru（（S）-Sunphos）（benzene）C1]C1 as the catalyst and CeC13·7H20 as the additive. A series of enantiopure -hydroxy Weinreb amides （up to 97% ee） have been obtained. Cata- lytic amount of CeC13·7H20 is essential for the high reactivity and enantioselectivity and the ratio of CeC13·7H20 to [Ru（（S）-Sunphos）（benzene）C1]C1 plays an important role in the hydrogenation reaction.
