In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip.The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxim...In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip.The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate.The effect of reaction time on the yield was determined and compared with the standard batch system.The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate,less consumption of reactants and labor contaminant,which proved microfluidic chip to be a powerful tool for synthetic applications.展开更多
Methoxybenzaldehyde is prepared from the addition-hydrolysis reaction of p-CH 3OC 6H 4MgBr with 1,3-disubstituted benzimidazolium salt. The reaction mechanism is discussed. 1,3-Dialkyl has little influence on the yield.
文摘In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip.The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate.The effect of reaction time on the yield was determined and compared with the standard batch system.The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate,less consumption of reactants and labor contaminant,which proved microfluidic chip to be a powerful tool for synthetic applications.
文摘Methoxybenzaldehyde is prepared from the addition-hydrolysis reaction of p-CH 3OC 6H 4MgBr with 1,3-disubstituted benzimidazolium salt. The reaction mechanism is discussed. 1,3-Dialkyl has little influence on the yield.
