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O-对甲脒苯氧烷基-N-取代酪氨酸甲酯的合成与抗血小板聚集活性
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作者 许天林 蒋巡天 +2 位作者 倪沛洲 华维一 裴咏梅 《药学学报》 CAS CSCD 北大核心 2000年第3期228-231,共4页
AIM: The synthesis and antiaggregation activity of a series of compounds with p amidinophenyl group and tyrosine methyl esters as their terminals were studied. METHODS and RESULTS: A series of O (4 aminoiminomethylphe... AIM: The synthesis and antiaggregation activity of a series of compounds with p amidinophenyl group and tyrosine methyl esters as their terminals were studied. METHODS and RESULTS: A series of O (4 aminoiminomethylphenyloxy)alkyl N substituted L tyrosine methyl esters were prepared from 4 cyanophenol, L tyrosine and different dihalo alkanes. All compounds (IVa~i) were new compounds. Their in vitro activity against ADP induced platelet aggregation were tested. The structure activity relationships were discussed. CONCLUSION: Some of the compounds showed antiaggregation activity on platelet rich plasma at the final concerntration of 1×10 -6 mol·L -1 . The potency of IVa~i showed that compounds with three methylene groups are better than those with four methylene groups on the same R substituent in the above series of compounds. 展开更多
关键词 对甲脒苯氯烷基 酪氨酸 合成 血小板聚集
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