The synthesis of a novel host blocked in the cone conformation and bearing m-methoxycarbonylbenzyl groups at the lower rim is described. X-ray crystal structure analysis revealed that action of one molecule of compoun...The synthesis of a novel host blocked in the cone conformation and bearing m-methoxycarbonylbenzyl groups at the lower rim is described. X-ray crystal structure analysis revealed that action of one molecule of compound upon one molecule of CH 3CN or one molecule of CH 3NO 2, forms an intramolecular inclusion complex, respectively, by CH 3-π interactions. The complex of L with tetrabutyl ammonium bromide(TBAB), L·TBAB, was obtained. The results of DTA-TG and XRD analysis of L·TBAB can also be considered as an intramolecular inclusion complex.展开更多
目的:建立毛细管区带电泳(CZE)分离/安培检测左旋多巴(DP)、多巴胺(DA)、肾上腺素(EP)、去甲肾上腺素(NE)、5-羟色胺(5-HT)5种儿茶酚胺类神经递质(CAs)药物的方法。方法:采用石英毛细管柱(60 cm×50μm),含8 mmol·L^(-1)对-(...目的:建立毛细管区带电泳(CZE)分离/安培检测左旋多巴(DP)、多巴胺(DA)、肾上腺素(EP)、去甲肾上腺素(NE)、5-羟色胺(5-HT)5种儿茶酚胺类神经递质(CAs)药物的方法。方法:采用石英毛细管柱(60 cm×50μm),含8 mmol·L^(-1)对-(季铵盐)杯[4]芳烃(QAC4A)的125 mmol·L^(-1)磷酸氢二钠溶液(Na_2HPO_4,pH 7.0)为缓冲液,分离电压6 kV,分离 CAs 并利用 Cu 微粒修饰碳纤维电极检测。结果:优化条件下5种 CAs 被基线分离,回收率为92%～105%,5种 CAs 在0.2～1000μmol·L^(-1)浓度内呈良好线性关系,最低检测限为0.2 μmol·L^(-1)。应用该方法成功地测定了5种 CAs 注射液、正常人和嗜铬细胞瘤患者尿样。结论:本法用于分离并检测 CAs 药物,具有准确、灵敏、简便的特点,适合该类药品分析。展开更多
文摘The synthesis of a novel host blocked in the cone conformation and bearing m-methoxycarbonylbenzyl groups at the lower rim is described. X-ray crystal structure analysis revealed that action of one molecule of compound upon one molecule of CH 3CN or one molecule of CH 3NO 2, forms an intramolecular inclusion complex, respectively, by CH 3-π interactions. The complex of L with tetrabutyl ammonium bromide(TBAB), L·TBAB, was obtained. The results of DTA-TG and XRD analysis of L·TBAB can also be considered as an intramolecular inclusion complex.
文摘目的:建立毛细管区带电泳(CZE)分离/安培检测左旋多巴(DP)、多巴胺(DA)、肾上腺素(EP)、去甲肾上腺素(NE)、5-羟色胺(5-HT)5种儿茶酚胺类神经递质(CAs)药物的方法。方法:采用石英毛细管柱(60 cm×50μm),含8 mmol·L^(-1)对-(季铵盐)杯[4]芳烃(QAC4A)的125 mmol·L^(-1)磷酸氢二钠溶液(Na_2HPO_4,pH 7.0)为缓冲液,分离电压6 kV,分离 CAs 并利用 Cu 微粒修饰碳纤维电极检测。结果:优化条件下5种 CAs 被基线分离,回收率为92%～105%,5种 CAs 在0.2～1000μmol·L^(-1)浓度内呈良好线性关系,最低检测限为0.2 μmol·L^(-1)。应用该方法成功地测定了5种 CAs 注射液、正常人和嗜铬细胞瘤患者尿样。结论:本法用于分离并检测 CAs 药物,具有准确、灵敏、简便的特点,适合该类药品分析。
