走向深度学习的“导学用”大课堂

"走向深度学习的导学用大课堂"是我校适应核心素养时代要求和高考综合改革而实施的深度教学改革,主要目的是针对高耗低效的教学现状,探索基于深度学习的导学用大课堂新体系,实现核心素养的教学转化,提高课堂教学效益,发展学生的核心素养。该项改革的主要实施策略是:有效预习、问题导学、课程整合、活动建构和嵌入式评价。历经四年多的不断探索,教改成果显著,大幅提升了教育教学质量,促进了广大教师的专业发展,推动了学校深度转型发展,彰显了育人特色。

“导学用三环节六步”课堂教学模式

“导学用三环节六步”课堂教学模式,导,即教师的引导;学,即学生的学习;用,即当堂训练。三大环节和“自主学习、合作学习、展示质疑、应用学习、整体建构、达标测试”六个连贯的教学步骤。一、自主学习即学生依据学案上的学习目标和设置的问题进行独立学习。教材是依据,学案是引导,问题是核心,学生在阅读教材中思考问题、学习问题、解决问题。自主学习就是让学生去试一试,并给了学生充分自由思考的时间。

微课在小学英语“课内翻”教学模式中应用

＂微课＂的出现,为教学观念与方式的变革带来新的机遇。如何通过＂微课＂构建小学英语思维课堂,提高学生的英语思维能力和运用能力是当前研究的热点问题。本文以小学英语《How do you feel》一节课为例,剖析运用＂微课＂,构建＂导、学、用＂的教学模式,通过＂三步导、三步学、三步用＂的教学策略,创设语用情境,搭建课内、课外适合学生发展的学习型课堂、思维型课堂,有效地培养和提高学生的思维能力和运用能力。

加强阅读教学 提升学生语文素养

阅读不仅是语文课堂教学的一项重要活动,更是一门艺术。在初中语文教学中,教师必须重视对学生阅读兴趣的培养,充分发挥学生在阅读中的主体地位,指导学生融入课本,由关注教转向关注学,“导学用”合一,促进学生阅读水平的提高,达到提升学生语文综合素养的目的。

Coupling characteristics between five-layer slab wave-guides including left-handed materials

To obtain the coupling characteristics between slab wave-guides including left-handed material,we modify the coupled wave equations by using Maxwell’s equations. First,we obtain new-coupled wave equations and new-coupling coefficient. Second,the coupling between two identical five-layer slab wave-guides where their cores are left-handed material,but their claddings are right-handed materials is studied. The coupling coefficient for even TE mode which is more complex than that of the riglt-handed material slab wave guides,is obtained.

Electrical Conductivity in Soil Extracts: Chemical Factors and Their Intensity

The electrical conductivity （EC） of 1：5 soil-water extract （EC1：5） was studied utilizing path coefficient analysis. The study focused on revealing the main chemical factors contributing to EC of soil extracts and their relative importance. Results showed that the most important factors influencing the EC1：5 of coastal salt-affected soils were the concentration of salt in 1：5 soil-water extract （So）, Cl^-, and the sodium adsorption ratio （SAR）, while effects of pH, CO3^2-, HCO3^, soluble sodium percentage （SSP）, and sodium dianion ratio （SDR） were very weak. Though the direct path coefficients between EC1：5 and SO4^2- , Ca^2＋, Mg^2＋, K^＋, or Na^＋ were not high, influence of other chemical factors caused the coefficients to increase, making the summation of their direct and indirect path coefficients relatively high. Evidences showed that multiple regression relations between EC1：5 and most of the primary factors （So, Cl^-, and SAR） had sound reliability and very good accuracy.

Stable transfection of extrinsic Smac gene enhances apoptosis-inducing effects of chemotherapeutic drugs on gastric cancer cells

AIM: To explore the feasibility of enhancing apoptosis-inducing effects of chemotherapeutic drugs on human gastric cancer cells by stable transfection of extrinsic Smac gene. METHODS: After Smac gene was transferred into gastric cancer cell line MKN-45, subclone cells were obtained by persistent G_(418) selection. Cellular Smac gene expression was determined by RT-PCR and Western blotting. After treatment with mitomycin (MMC) as an apoptotic inducer, in vitro cell growth activities were investigated by trypan blue-staining method and MTT colorimetry. Cell apoptosis and its rates were determined by electronic microscopy, annexin V-FTTC and propidium iodide staining flow cytometry. Cellular caspase-3 protein expression and its activities were assayed by Western blotting and colorimetry. RESULTS: When compared with MKN-45 cells, the selected subclone cell line MKN-45/Smac had significantly higher Smac mRNA (3.12±0.21 vs 0.82±0.14, t=7.52, P＜0.01) and protein levels (4.02±0.24 vs0.98±0.11, t=8.32, P＜0.01). After treatment with 10 μg/mL MMC for 6-24 h, growth inhibition rate of MKN-45/Smac (15.8±1.2-54.8±2.9%) was significantly higher than that of MKN-45 (5.8±0.4-24.0±1.5%, t=6.42, P＜0.01). Partial MKN-45/Smac cancer cells presented characteristic morphological changes of apoptosis under the electronic microscope with an apoptosis rate of 36.4±2.1%, which was significantly higher than that of MKN-45 (15.2±0.8%, t=9.25, P＜0.01). Compared with MKN-45, caspase-3 expression levels in MKN-45/Smac were improved significantly (3.39±0.42 vs0.96±0.14, t=8.63, P＜0.01), while its activities were 3.25 times as many as those of MKN-45 (0.364±0.010 vs0.112±0.007, t=6.34, P＜0.01). CONCLUSION: Stable transfection of extrinsic Smac gene and its over-expression in gastric cancer cell line can significantly enhance cellular caspase-3 expression and activities, ameliorate apoptosis-inducing effects of mitomycin C on cancer cells, which is a novel strategy to improve chemotherapeutic effects on gastric cancer.

Effects of the Production-Oriented Approach on EFL Learners’Writing Performance in China’s Tertiary Education

The Production-Oriented Approach(POA)has been proposed as a remedy for overcoming the problem of input-output separation in the traditional text-centered teaching and learning paradigm in tertiary education in China.This two-week quasi-experimental study investigated the effect of the POA,compared with the traditional text-centered Intensive Reading Approach(IRA),on college students’L2 writing performance in terms of overall quality of the writing and its components of language,idea,and discourse structure.Data included writing samples of both experimental and control groups before and after classroom instruction and the results of a language achievement test on mastery of target language forms predicating students’language use in writing.The results showed that:1)no significant difference was found between the two groups either in the overall quality or in the“idea”and“structure”of the written texts;2)the experimental group outperformed the control group with respect to language use,in terms of both language quality and the frequency of target language use.These results indicated that the POA might have an advantage over the IRA in facilitating learners’writing development.

Effects of Matrine on Aconitine-Induced Electrophysiological Changes in Rat Ventricular Myocytes

Aim To explore the reason that the antiarrhythmic effect of the extract oftraditional Chinese medicinal herb, matrine, is weaker than quinidine and verapamil by comparison ofthe effect and efficacy of matrine on various kinds of transmembrane ionic currents with those ofquinidine and verapamil; and to demonstrate the best targets for antiarrhythmic drugs. MethodsWhole-cell patch-clamp techniques were used to record the action potential and ionic currents insingle cells of rat ventricular myocytes. Aconitine was used to induce the changes of ioniccurrents, then study the effects of matrine and quinidine, verapamil on aconitine-induced unbalancedchannel currents and action potential. Results Aconitine 1 μmol·L^(-1) induced significantchanges in transmembrane currents and action potential in single cells of rat ventricular myocytes.APD was significantly prolonged by aconitine. Simultaneously, aconitine increased sodium, L-typecalcium and inward rectifier potassium currents. Matrine 100 μmol· L^(-1) reversed theaconitine-induced changes of sodium current (I_(Na)) from (-70.2+- 10.5) pA/pF to ( - 39.6+-4.0)pA/pF(n = 5, P < 0.05 vs aconitine); L-type calcium current (I_(Ca-L)) from (20.4+- 3.8) pA/pF to (- 12.9+- 2.9) pA/pF ( n = 6, P < 0.01); the inward rectifier potassium current (I_(k1) ) from (-32.2+- 1.08) pA/pF to ( -24.0+-3.4) pA/pF (n = 6, P < 0.01), and action potential duration. Thereversal effects of quinidine and verapamil on aconitine-induced changes of APD and ionic currentswere more marked than matrine. Conclusion Aco-nitine significantly disturbs the normal equilibriumof ion channels in ventricular myocytes. It induces changes of I_(Na), I_(Ca-L), I_(K1) andprolongation of action potential duration. Matrine at concentration 50 or 100 μmol·L^(-1)statistically significantly suppresses aconitine-induced changes of APD and ionic currents. Thepotency and efficacy of inhibitory effect of matrine are markedly weaker than those of commonly usedverapamil and quinidine.

A Case Study of an Experienced University EFL Teacher’s Use of POA Teaching Materials

Although research on teaching materials use has important implications for materials development,little literature examines how teachers actually use materials in the classroom.The present study,taking the theoretical framework for using and evaluating Production-Oriented Approach(POA)teaching materials(Wen,2017),explores the procedure and the rationale of an experienced Chinese university EFL teacher’s use of POA teaching materials.Multiple methods were employed in data collection,including classroom observations,teacher interviews,the teacher’s lesson plans,and PowerPoints,as well as students’written and oral products.Data analysis showed that the teacher followed a three-phase process of materials use.Before class,teaching objectives were set,materials were selected,adapted,and then transformed into teaching activities.During class,the teaching activities were implemented with the materials.After class,the effectiveness of using the materials was assessed.The study revealed that the teacher played an active role in practicing the essential POA principles of“productive-objectives-determined”and“input-in-service-to-output”in the entire process of material use.

P-glycoprotein mediated interactions between Chinese materia medica and pharmaceutical drugs

P-glycoprotein(P-gp)is an important transmembrane ATP-binding cassette(ABC)drug efflux transporter expressed in various human tissues such as the intestines,liver,kidneys,and bloodbrain barrier.It limits the intracellular concentration of xenobiotics by pumping them out of the cells,affecting drug pharmacokinetics and therapeutic effects.With its broad substrate specificity,it has the potential to remove a wide range of drugs from Chinese materia medica(CMM),including conventional medicines and active compounds.Increasing evidence has confirmed the superior therapeutic effectiveness of CMM in treating a wide range of diseases worldwide,as well as in conjunction with western drugs.As a result,herbal medicine-drug compounds have prompted widespread concern,with the majority of these interactions involving transporters such as P-gp.This review systematically summarizes the inhibition or induction of P-gp expression/function by active CMM compounds and the underlying regulatory mechanisms.It will aid in improving understanding of the synergistic or inhibiting effects associated with transporter P-gp as well as rational safety concerns for using CMM,particularly in combination with drugs.

A Quantized Kernel Least Mean Square Scheme with Entropy-Guided Learning for Intelligent Data Analysis

Quantized kernel least mean square(QKLMS) algorithm is an effective nonlinear adaptive online learning algorithm with good performance in constraining the growth of network size through the use of quantization for input space. It can serve as a powerful tool to perform complex computing for network service and application. With the purpose of compressing the input to further improve learning performance, this article proposes a novel QKLMS with entropy-guided learning, called EQ-KLMS. Under the consecutive square entropy learning framework, the basic idea of entropy-guided learning technique is to measure the uncertainty of the input vectors used for QKLMS, and delete those data with larger uncertainty, which are insignificant or easy to cause learning errors. Then, the dataset is compressed. Consequently, by using square entropy, the learning performance of proposed EQ-KLMS is improved with high precision and low computational cost. The proposed EQ-KLMS is validated using a weather-related dataset, and the results demonstrate the desirable performance of our scheme.

Using Transformation Thought to Simplify Reciprocal Function Derivatives

Derivatives are the foundation of mathematical calculations,however,for some functions, using the rules of finding a derivative may lead to cumbersome steps. Therefore, this paper provides a simple way using transformation thought for the reciprocal function derivative.

Gas diffusion in a cylindrical coal sample – A general solution,approximation and error analyses

The analytical mathematical solutions of gas concentration and fractional gas loss for the diffusion of gas in a cylindrical coal sample were given with detailed mathematical derivations by assuming that the diffusion of gas through the coal matrix is concentration gradient-driven and obeys the Fick’s Second Law of Diffusion.The analytical solutions were approximated in case of small values of time and the error analyses associated with the approximation were also undertaken.The results indicate that the square root relationship of gas release in the early stage of desorption,which is widely used to provide a simple and fast estimation of the lost gas,is the first term of the approximation,and care must be taken in using the square root relationship as a significant error might be introduced with increase in the lost time and decrease in effective diameter of a cylindrical coal sample.

Study on dynamic model of tractor system for automated navigation applications

This research aims at using a dynamic model of tractor system to support navigation system design for an automati- cally guided agricultural tractor. This model, consisting of a bicycle model of the tractor system, has been implemented in the MATLAB environment and was developed based on a John Deere tractor. The simulation results from this MATLAB model was validated through field navigation tests. The accuracy of the trajectory estimation is strongly affected by the determination of the cornering stiffness of the tractor. In this simulation, the tractor cornering stiffness analysis was identified during simulation analysis using the MATLAB model based on the recorded trajectory data. The obtained data was used in simulation analyses for various navigation operations in the field of interest. The analysis on field validation test results indicated that the developed tractor system could accurately estimate wheel trajectories of a tractor system while operating in agricultural fields at various speeds. The results also indicated that the developed system could accurately determine tractor velocity and steering angle while the tractor operates in curved fields.

Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin(C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective eff ects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglyceride(TG), total cholesterol(CHOL), low-density lipoprotein(LDL), liver homogenate malondialdehyde(MDA), superoxide dismutase(SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory eff ects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.

Precision medicine in the treatment of pancreatic ductal adenocarcinoma

Pancreatic cancer has a poor prognosis. Current therapies for pancreatic cancer have limited effects. In the past decade, precision medicine has shown great potential for clinical applications. In this review, different strategies for applying precision medicine to the treatment of pancreatic cancer are described.

Determination of consolidation behaviour of clay slurries

The main objective of this study was to determine the consolidation behaviour of clay slurries.A finegrained clay with high consistency limits(W_L = 180%,w_P= 120%) was investigated using conventional oedometer and bench-top centrifuge tests.Results indicated that the slurry had an apparent preconsolidation(due to initial conditions,electrochemical interactions,tortuous drainage,and thixotropic strength) from e = 5.7 to e = 5.5 followed by virgin compression.Likewise,the low hydraulic conductivity(10^(-10)-10^(-12) m/s) was due to low porosity(small pore throats) and high tortuosity(long flow paths).Unlike consolidation of soils,the c_v and m_v decreased with increasing σ' but increased with increasing e and k.The data from the two tests correlated well in the range of σ' = 10-65 kPa,e = 5.5-3.86,k= 1.7 × 10^(-10)-5×10^(-11) m/s,F_c = 1-40 MN.New equations were developed to correlate the consolidation parameters(e,σ',k) with F_c.The deviation of k beyond 40 MN(e = 4.65) was due to deviation from the initial straight line portion of the settlement curve in the centrifuge test.

Research of chemical induction unit on mixing effect and chlorine saving

Rapid mixing and chlorine saving are two important problems that most drinking water industries are focus on, and this paper adopts chemical induction unit to compare with water jet injector to study what merits chemical induction unit has. The experiment chose coefficient of variability of chlorine concentration to evaluate the mix effect and used chlorine consumption to compare the two equipments. Distribution reservoir experiments show that chemical induction unit can completely mix chlorine less than 6.2 seconds and water jet injector can not completely mix in 3 minutes. Mixing pool experiments show that chemical induction unit can save chlorine compared with water jet injector, and can save more if more chlorine is consumed.

Remedial Learning： A CALL Approach

Computer Assisted Language Learning （CALL） has been in use as a learner centered method since 1960. In this paper an attempt is made to evolve a Remedial Grammar （RG） which enables the teacher to develop a repertoire of remedial activities based on the errors identified following Error Analysis （EA） for repeated presentation. The error types are considered as teaching/learning points. The present paper argues that CALL is the right model for effective remedial learning. Remedial Gmaster （RGm）, an authoring package is introduced. This is an exclusive mode of error correction in which interlingual, intralingual, developmental, and global errors are dealt with. The syntactical problems due to the subtle difference between simple past and perfect tenses in English language use are discussed and CALL authoring package presented.