A resistor-capacitor(RC)circuit model is proposed to study the effect of nanosecond pulsed electricfield on cells according to the structure and electrical parameters of cells.After a nanosecond step fieldhas been app...A resistor-capacitor(RC)circuit model is proposed to study the effect of nanosecond pulsed electricfield on cells according to the structure and electrical parameters of cells.After a nanosecond step fieldhas been applied,the variation of voltages across cytomembrane and mitochondria membrane both in nor-mal and in malignant cells are studied with this model.The time for selectively targeting the mitochondriamembrane and malignant cell can be evaluated much easily with curves that show the variation of voltageacross each membrane with time.Ramp field is the typical field applied in electrobiology.The voltagesacross each membrane induced by ramp field are analyzed with this model.To selectively target the mito-chondria membrane,proper range of ramp slope is needed.It is relatively difficult to decide the range ofa slope to selectively affect the malignant cell.Under some conditions,such a range even does not exist.展开更多
Based on the rapid experimental developments of circuit QED,we propose a feasible scheme to simulate the spin-boson model with superconducting circuits,which can be used to detect quantum Kosterlitz-Thouless(KT) phase...Based on the rapid experimental developments of circuit QED,we propose a feasible scheme to simulate the spin-boson model with superconducting circuits,which can be used to detect quantum Kosterlitz-Thouless(KT) phase transition.We design the spinboson model by using a superconducting phase qubit coupled to a semi-infinite transmission line,which is regarded as a bosonic reservoir with a continuum spectrum.By tuning the bias current or the coupling capacitance,the quantum KT transition can be directly detected through tomography measurement on the states of the phase qubit.We also estimate the experimental parameters using the numerical renormalization group method.展开更多
基金Supported by National Natural Science Foundation of China (50477007)
文摘A resistor-capacitor(RC)circuit model is proposed to study the effect of nanosecond pulsed electricfield on cells according to the structure and electrical parameters of cells.After a nanosecond step fieldhas been applied,the variation of voltages across cytomembrane and mitochondria membrane both in nor-mal and in malignant cells are studied with this model.The time for selectively targeting the mitochondriamembrane and malignant cell can be evaluated much easily with curves that show the variation of voltageacross each membrane with time.Ramp field is the typical field applied in electrobiology.The voltagesacross each membrane induced by ramp field are analyzed with this model.To selectively target the mito-chondria membrane,proper range of ramp slope is needed.It is relatively difficult to decide the range ofa slope to selectively affect the malignant cell.Under some conditions,such a range even does not exist.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11004065,11104057 and 11125417)the Natural Science Foundation of Guangdong Province (Grant No.10451063101006312)+1 种基金the State Key Program for Basic Research of China(Grant No. 2011CB922104)the GRF and CRF of the RGC of Hong Kong
文摘Based on the rapid experimental developments of circuit QED,we propose a feasible scheme to simulate the spin-boson model with superconducting circuits,which can be used to detect quantum Kosterlitz-Thouless(KT) phase transition.We design the spinboson model by using a superconducting phase qubit coupled to a semi-infinite transmission line,which is regarded as a bosonic reservoir with a continuum spectrum.By tuning the bias current or the coupling capacitance,the quantum KT transition can be directly detected through tomography measurement on the states of the phase qubit.We also estimate the experimental parameters using the numerical renormalization group method.
