寿成超团队揭示土茯苓提取物aiphanol抗血管生成作用及机制

2021年12月3日,北京大学肿瘤医院寿成超教授的研究团队在Signal Transduction and Targeted Therapy杂志在线发表了题为“Aiphanol,a native compound,suppresses angiogenesis via dual-targeting VEGFR2 and COX2”的研究论文,阐述了土茯苓提取物aiphanol通过VEGFR2和COX2双靶点拮抗血管生成的作用机制,为后续开发新型抗肿瘤药物奠定了重要基础。

仆人窃酒

有个喜欢收藏美酒的有钱人名叫汤姆,他做事总是马马虎虎、丢三落四的。他的这个坏习惯被一个爱耍小聪明的仆人注意到了,于是仆人暗中琢磨如何从主人那儿偷点酒喝而不被发现。汤姆有一个9个格子的酒柜,四周的8个格子里总是摆着瓶酒,只有中间的格子空着。

Durability zonation standard of concrete structure design

Durability zonation standard （DZS） is proposed to provide useful parameters for durable concrete structure design. It deals not only with the influence of environment on structures, but also with types, functions and importance of structures based on the theory of life cycle cost（LCC）. First, the basic concept of DZS for concrete structure design is defined. Then the basic principles for DZS are established. The factors for zonation according to natural environmental conditions and structural importance are identified. The usefulness of DZS by citing a real application for concrete highway bridges in Zhejiang Province is demonstrated. Finally, durability regulations are provided accordingly to zonation.

“兴昌杯”京华企业家征文活动颁奖

昌平县人民政府、首都企业家俱乐部、《学习与研究》杂志社联合举办的“兴昌杯”京华企业家征文活动,3月30日在昌平县召开发奖会。市委宣传部副部长刘述礼、市总工会主席商宝坤、市商委主任臧洪阁、市工委副书记彭静云、昌平县副县长史静贤等同志向获奖的作者和被记述的企业家颁发了奖品和纪念品。

Construction of project quality health monitoring system based on life-cycle theory

In order to more effectively assess the health status of a project, the monitoring indices in a project＇s life cycle are divided into quality index, cost index, time index, satisfaction index, and sustainable development index. Based on the feature of qualitative and quantitative indices combining, the PCA-PR （principal component analysis and pattern recognition） model is constructed. The model first analyzes the principal components of the life-cycle indices system constructed above, and picks up those principal component indices that can reflect the health status of a project at any time. Then the pattern recognition model is used to study these principal components, which means that the real time health status of the project can be divided into five lamps from a green lamp to a red one and the health status lamp of the project can be recognized by using the PR model and those principal components. Finally, the process is shown with a real example and a conclusion consistent with the actual situation is drawn. So the validity of the index system and the PCA-PR model can be confirmed.

和谐社会有来时

雪皓梅香时,归燕闹新枝。春暖催斜柳,两会和风驰。踏着春天的节拍,带着对未来美好向往,2007午全国"两会"沐浴着春日的阳光,在全世界的瞩目下圆满闭幕了。本届两会在人们的热切盼望中又通过了两部关系到民生的大法——物权法与企业所得税法,又掀开了我国迈向小康社会的重要一步。

第四届中国中小企业全球发展论坛成功举行

9月15日,欧亚会展国际酒店总经理吴俊彬先生与欧亚会展国际酒店常务副总经理向军先生、欧亚会展国际酒店副总经理何文心先生一同会见了德国前总统武尔夫先生、韩国前总理李寿成先生、原国家外经贸部副部长龙永图先生。当晚,所有嘉宾一起参加了＂第四届中国中小企业全球发展论坛＂的中秋晚宴。次日,第四届中国中小企业全球发展论坛正式开始,会场内座无虚席。

人生旅途

中田英寿Hidetoshi Nakata生日：1977年1月22日身高：1．75米体重：72公斤荣誉：1997年日本J联赛最佳球员1997年亚足联年度最佳球员1998年亚足联年度最佳球员1998年亚足联全明星队1999年亚足联全明星队2001年意甲冠军我们曾经把过早退役的球星称为“英年早逝”,非常不幸,中田英寿成为了其中的一份子。如果要评选最近十年最成功的亚洲球员,韩国人会投洪明甫一票,伊朗人会选择阿里·代伊,沙特人心中的答案是贾贝尔,

创新荒漠化防治模式 共建人类美好家园

尊敬的约翰·布鲁顿先生、李寿成先生,黄孟复、董建华、万钢副主席,女士们、先生们、朋友们:在全球携手合作、开创绿色未来的大背景下,"2011库布其国际沙漠论坛"在内蒙古美丽的七星湖畔隆重召开。全国政协贾庆林主席专门发来贺信。

Remaining Useful Life Prediction of Aeroengine Based on Principal Component Analysis and One-Dimensional Convolutional Neural Network

In order to directly construct the mapping between multiple state parameters and remaining useful life(RUL),and reduce the interference of random error on prediction accuracy,a RUL prediction model of aeroengine based on principal component analysis(PCA)and one-dimensional convolution neural network(1D-CNN)is proposed in this paper.Firstly,multiple state parameters corresponding to massive cycles of aeroengine are collected and brought into PCA for dimensionality reduction,and principal components are extracted for further time series prediction.Secondly,the 1D-CNN model is constructed to directly study the mapping between principal components and RUL.Multiple convolution and pooling operations are applied for deep feature extraction,and the end-to-end RUL prediction of aeroengine can be realized.Experimental results show that the most effective principal component from the multiple state parameters can be obtained by PCA,and the long time series of multiple state parameters can be directly mapped to RUL by 1D-CNN,so as to improve the efficiency and accuracy of RUL prediction.Compared with other traditional models,the proposed method also has lower prediction error and better robustness.

Quality-Oriented Facade Systems： Initial Investments vs. Global Cost Approach

An analysis applied to an existing building considering the whole service life, regulated or, if any, measured, of energy/technological upgrading action does not only require initial investments to be taken into account. Of course, such investments are significant and will have to be considered at a first stage, but it is not the only aspect to be considered. Provisions of Construction Procurement Guidance, No.7 Whole Life Costs state： ＂All procurement must be made solely on the basis of value for money in terms of the optimum combination of global costs--and not only initial investment costs--and quality to meet the user＇s requirements＂.

Effects of salinity on egg and fecal pellet production, development and survival, adult sex ratio and total life span in the calanoid copepod, A cartia tonsa:a laboratory study

The ef fects of salinity on the copepod, A cartia tonsa in terms of daily egg production rate(EPR), hatching success, fecal pellet production rate(FPR), naupliar development time and survival, sex ratio, and total life span were determined in laboratory conditions through three experiments. In experiment 1, EPR, hatching success, and FPR of individual females were monitored at salinities of 13, 20, 35 and 45 during short-periods(seven consecutive days). Results show EPR was aff ected by salinity with the highest outputs recorded at 20 and 35, respectively, which were considerably higher than those at 13 and 45. Mean FPR was also higher in 35 and 20. In experiment 2, the same parameters were evaluated over total life span of females(long-term study). The best EPR and FPR were observed in 35, which was statistically higher than at 13 and 20. In experiment 3, survival rates of early nauplii until adult stage were lowest at a salinity of 13. The development time increased with increasing of salinity. Female percentage clearly decreased with increasing salinity. Higher female percentages(56.7% and 52.2%, respectively) were signifi cantly observed at two salinities of 13 and 20 compared to that at 35(25%). Total longevity of females was not af fected by salinity increment. Based on our results, for mass culture we recommend that a salinity of 35 be adopted due to higher reproductive performances, better feeding, and faster development of A. tonsa.

High-Speed EMU TCMS Design and LCC Technology Research

This paper introduces the high-speed electrical multiple unit （EMO） life cycle, including the design, manufacturing, testing, and maintenance stages. It also presents the train control and monitoring system （TCMS） software development platform, the TCMS testing and verification bench, the EMU driving simulation platform, and the EMU remote data transmittal and maintenance platform. All these platforms and benches combined together make up the EMU life cycle cost （LCC） system. Each platform facilitates EMU LCC management and is an important part of the system.

Application of stochastic method to optimum design of energy-efficient induction motors with a target of LCC

For an energy-efficient induction machine, the life-cycle cost (LCC) usually is the most important index to the consumer. With this target, the optimization design of a motor is a complex nonlinear problem with constraints. To solve the problem, the authors introduce a united random algorithm. At first, the problem is divided into two parts, the optimal rotor slots and the optimization of other dimensions. Before optimizing the rotor slots with genetic algorithm ( GA), the second part is solved with TABU algorithm to simplify the problem. The numerical results showed that this method is better than the method using a traditional algorithm.

The Post-exposure Effects of Spinosad and Plant Allelochemicals on Biological Characteristics of Helicoverpa armigera(Lepidoptera： Noctuvidae)

In order to define the combined effects of spinosad and plant allelochemicals on Helicoverpa armigera(Lepidoptera:Noctuvidae), the research fed them on artificial diets with different doses of spinosad, gossypol, quercetin and tannicacid, and the changes of pupal and imaginal biological characteristics were observed and recorded. The results showed that spinosad at sublethal concentrations decreased pupation ratio and pupal weight, prolonged prepupal and pupal periods, and decreased emergence ratio, fecundity and longevity of adults. Combined with plant allelochemicals, spinosad significantly prolonged pupal period and shorten adult longevity. Other life-cycle parameters such as pupation ratio, pupal weights, emergence ratio, eggs laid per female and hatch ratio did not change significantly. The results clearly indicated that plant allelochemicals did not change spinosad efficiency on H. armigera, but the combination of spinosad and plant allelochemicals might affect pest population dynamics significantly by changing its development.

Estimating the Service Lives of Building Products in Use

Reliable service life data of building products are of great importance when completing environmental LCA （life cycle assessment） reviews, for LCC （life cycle costing） and for maintenance planning tasks. A research project was set up to answer the following research questions： （1） what are reliable service life data of current used building products; and （2） how can generic data about the service lives of building products be tailored to specific project circumstances using the ＂factor method＂ described in the ISO （International Standard Organization） 15686 Series： ＂Buildings and Constructed Assets-Service-Life Planning＂. Experts of industry organisations for building materials and products made a final judgement of the new established reference service lives. Reference service lives of building products may show a large unknown bandwidth around the average. That will make the bandwidth of estimated service lives, taking the project situation of building components into account, very big. Experts have raised objections to the use the factor method for deriving mathematically a bandwidth of estimated service lives of a building product from the reference service life of the product. A practical analytical application of the factor method has been made by describing all factors and underlying criteria and a reference situation.

The Use of Life Cycle Cost Analysis to Determine the Most Effective Cost of Installation High Voltage Undersea Cable Bali Strait

Indonesian National Electricity Company （PT.PLN （Persero）） has planned to install additional high voltage undersea cable for circuit llI and IV Java-Bali to fulfill electricity demand in Bali. This project was more prefered compared to building another power plant in Bali which could raise social and cultural resistance. Life cycle cost method was used to complete the financial feasibility study to ensure if the project has economic benefit, and the asset would be used effectively and efficiently along its benefit period. In this paper, a life cycle cost will be simulated to analyze which alternative is the most profitable： installation circuit III and IV in 2012 or installation circuit III in 2012 and circuit IV in 2017 in accordance with load forecasting demand. This study is used to help the management to make a decision about the project.

Effect of Different Shading Practices Used at Pre-harvest Stage on Quality and Storage Life of Sultana Seedless Grapes

Covering the grapevine rows to delay maturity and thus the harvest date becomes a widespread practice at Sultana seedless vineyards. The research work was carried out with different covers to examine their effects on grape quality and storage life in 2009 and 2010. Grapevines were covered with three different densities （shading ratios： 35%, 55%, 75%） at the veraison period. Unshaded （0%） control grapevines and grapevines shaded under different ratios were covered with polypropylene cross-stitch just before harvest maturity. Grapes under cover were harvested nearly one month after than those maturing under open conditions. Grape clusters were packed in PE bags and pre-cooled after harvest and then SO2-generating pads has been put on top, bags were sealed. In the second year at the 120th day of the storage, decay development has been observed in all applications. Total soluble solids content, maturity index and a＊ colour value were found lower in 55% and 75% shaded grapes compared to unshaded grapevines. Still, berry removal force and hue angle value in 55% and 75% of shaded grapes were higher than unshaded grapes. Effects of shading ratios on these parameters decrease or disappear at the end of storage.

Glass Melting Phenomena of a Fluorescent Lamp and a Protection Method by a Metal Ring

The formation mechanism of the discharge spot at a bottom of a lead wire in a fluorescent lamp at end-of-life is investigated. When the lamp at end-of life is ignited by applying high voltage, glow-like discharge is formed on the surface of the lead wire. A few seconds later, a bright spot is formed at the bottom 0fthe lead-wire. Then the stem glass on which the lead-wires are mounted begins to melt. High electric field is formed between the surface of the lead-wire and the stem glass surrounding the lead wire. Then discharge spot will be formed at the contact portion of the lead wire to the stem glass by this high electric field. To prevent discharge spot formation at the bottom of the lead wire, the metal ring is set to encircle the lead wire and is connected to the lead wire potential through a resistor. By this configuration, discharge spot formation is effectively suppressed. The mechanism for preventing hot discharge spot formation by the metal ring is discussed.

Micro porosity and its effect on fatigue performance of 7050 aluminum thick plates

Micro porosity in aluminum alloys may contribute to fatigue life degradation, which can largely limit the application of alloys. Therefore, the fatigue life of a commercial 7050-T7451 thick plate and an experimental plate with different porosities was compared in this study. The X-ray computed tomography(XCT) was utilized to characterize the size, number density and spatial distribution of porosity inside various samples, and the fracture surface of fatigued specimens was compared by using scanning electron microscope(SEM). The results showed that the fatigue cracks prefer to initiate from constituent particles in the commercial alloy. Whereas the micro porosity is the predominant site for crack nucleation and subsequent failure in the experimental one. The presence of micro porosity in experimental7050-T7451 thick plate may reduce the fatigue life by an order of magnitude or more compared with the defect-free alloy. The pores close to sample surface are the main fatigue crack initiation site, among which larger and deeper pore leads to a shorter fatigue life. The crack initiation is also affected by the pore geometry and direction. Besides, the overall porosity inside the bulk can affect the crack propagation during fatigue tests.