目的探讨体部伽玛刀低分割放射治疗(hypofractionated radiotherapy)对老年非小细胞肺癌患者肺功能的影响。方法对45例年龄>70岁的NSCLC患者实施体部伽玛刀低分割放射治疗,处方剂量为(40～52)Gy/(8～12)次,中位剂量48 Gy。每例患者...目的探讨体部伽玛刀低分割放射治疗(hypofractionated radiotherapy)对老年非小细胞肺癌患者肺功能的影响。方法对45例年龄>70岁的NSCLC患者实施体部伽玛刀低分割放射治疗,处方剂量为(40～52)Gy/(8～12)次,中位剂量48 Gy。每例患者分别在治疗前,以及治疗后1、3、6月进行肺功能检测,检测指标包括第1秒用力呼气量(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、一氧化碳(CO)弥散量(diffusing capacity of lung for carbon monoxide,DL-CO)。结果全组体部伽玛刀近期有效率为93.3%(42/45),1年生存率为82.2%(37/45)。放疗后1月,FEV1%得到改善(P<0.05),DLCO%无明显变化(P>0.05);放疗后3月,患者肺功能下降(P<0.05);放疗后6月,患者肺功能进一步下降(P<0.05)。结论体部伽玛刀低分割放射治疗对老年非小细胞肺癌患者是一种有效的治疗方式,同时也会对肺功能产生一定的影响。展开更多
A two-stage method for image segmentation based on edge and region information is proposed. Different deformation schemes are used at two stages for segmenting the object correctly in image plane. At the first stage, ...A two-stage method for image segmentation based on edge and region information is proposed. Different deformation schemes are used at two stages for segmenting the object correctly in image plane. At the first stage, the contour of the model is divided into several segments hierarchically that deform respectively using affine transformation. After the contour is deformed to the approximate boundary of object, a fine match mechanism using statistical information of local region to redefine the external energy of the model is used to make the contour fit the object's boundary exactly. The algorithm is effective, as the hierarchical segmental deformation makes use of the globe and local information of the image, the affine transformation keeps the consistency of the model, and the reformative approaches of computing the internal energy and external energy are proposed to reduce the algorithm complexity. The adaptive method of defining the search area at the second stage makes the model converge quickly. The experimental results indicate that the proposed model is effective and robust to local minima and able to search for concave objects.展开更多
文摘目的探讨体部伽玛刀低分割放射治疗(hypofractionated radiotherapy)对老年非小细胞肺癌患者肺功能的影响。方法对45例年龄>70岁的NSCLC患者实施体部伽玛刀低分割放射治疗,处方剂量为(40～52)Gy/(8～12)次,中位剂量48 Gy。每例患者分别在治疗前,以及治疗后1、3、6月进行肺功能检测,检测指标包括第1秒用力呼气量(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、一氧化碳(CO)弥散量(diffusing capacity of lung for carbon monoxide,DL-CO)。结果全组体部伽玛刀近期有效率为93.3%(42/45),1年生存率为82.2%(37/45)。放疗后1月,FEV1%得到改善(P<0.05),DLCO%无明显变化(P>0.05);放疗后3月,患者肺功能下降(P<0.05);放疗后6月,患者肺功能进一步下降(P<0.05)。结论体部伽玛刀低分割放射治疗对老年非小细胞肺癌患者是一种有效的治疗方式,同时也会对肺功能产生一定的影响。
基金Sponsored by Shanghai Leading Academic Discipline Project(Grant No T0603)the National Natural Science Foundation of China (Grant No60271033)
文摘A two-stage method for image segmentation based on edge and region information is proposed. Different deformation schemes are used at two stages for segmenting the object correctly in image plane. At the first stage, the contour of the model is divided into several segments hierarchically that deform respectively using affine transformation. After the contour is deformed to the approximate boundary of object, a fine match mechanism using statistical information of local region to redefine the external energy of the model is used to make the contour fit the object's boundary exactly. The algorithm is effective, as the hierarchical segmental deformation makes use of the globe and local information of the image, the affine transformation keeps the consistency of the model, and the reformative approaches of computing the internal energy and external energy are proposed to reduce the algorithm complexity. The adaptive method of defining the search area at the second stage makes the model converge quickly. The experimental results indicate that the proposed model is effective and robust to local minima and able to search for concave objects.
