Objectives - The aim of this prospective study was to evaluate the feasibility of radiofrequency ablation of hepatic tumors. We studied the rates of mortality, morbidity, and recurrence and recorded overall and diseas...Objectives - The aim of this prospective study was to evaluate the feasibility of radiofrequency ablation of hepatic tumors. We studied the rates of mortality, morbidity, and recurrence and recorded overall and disease-free survival. Methods - All patients aged over 18 years with histologically proven malignant liver disease inaccessible to surgical treatment (one to four tumor localizations) were eligible for inclusion in the study. Child-Pugh score > B9, platelets count ≤ 50× 103/mm3, prothrombin index ≤ 50% and pregnancy were exclusion factors. Results - Between July 2001 and June 2004, 51 patients (13 women, 38 men, mean age 66 ± 9 years) were included and underwent 61 radiofrequency thermal ablation procedures for 82 hepatic lesions: hepatocarcinoma (N = 44), cholangiocarcinoma (N = 1), metastasic tumors (N = 37). Hospital morbidity and mortality were 11.5% and 2% respectively. Recurrence rate at 3 years was 20.6% . In multivariate analysis, only tumor size > 3 cm was correlated significantly with recurrence (P = 0.03). Actuarial 1- , 2- and 3- year survival rates in the hepatocarcinoma group (N = 31) were 84.7% , 57.7% and 34.6% respectively. Actuarial 1- , 2- and 3- year survival rates in the metastasis from colorectal adenocarcinoma group (N = 14) were 90% , 54% and 54% respectively (P = 0.72). Conclusion - Radiofrequency thermal ablation is an effective treatment for hepatic tumors measuring less than 3 cm. There is a low risk of complications and open surgery can be associated. However in the Absence of randomized studies comparing radiofrequency and surgery, respective indications cannot be defined in detail.展开更多
分析颈背根神经射频热凝消融术联合内热针刺治疗颈源性头痛的临床疗效。方法 选择我院2022年1月-2022年12月颈源性头痛患者共116例,信封法随机分2组每组58例,对照组的患者给予颈背根神经射频热凝消融术治疗,观察组在该基础上增加内热针...分析颈背根神经射频热凝消融术联合内热针刺治疗颈源性头痛的临床疗效。方法 选择我院2022年1月-2022年12月颈源性头痛患者共116例,信封法随机分2组每组58例,对照组的患者给予颈背根神经射频热凝消融术治疗,观察组在该基础上增加内热针刺治疗。比较两组颈源性头痛缓解时间、治疗前后患者视觉模拟评分、颈椎活动度ROM评分、细胞因子 P 物质、白介素-6监测水平、总有效率、复发率。结果 观察组颈源性头痛缓解时间短于对照组,治疗后患者视觉模拟评分、颈椎活动度ROM评分、细胞因子 P 物质、白介素-6监测水平优于对照组,总有效率高于对照组,P<0.05。观察组复发率低于对照组,P<0.05。结论 颈背根神经射频热凝消融术联合内热针刺治疗对于颈源性头痛的治疗效果确切,可缓解颈椎疼痛和改善颈椎活动度,改善细胞因子水平,可有效降低疾病复发率。展开更多
文摘Objectives - The aim of this prospective study was to evaluate the feasibility of radiofrequency ablation of hepatic tumors. We studied the rates of mortality, morbidity, and recurrence and recorded overall and disease-free survival. Methods - All patients aged over 18 years with histologically proven malignant liver disease inaccessible to surgical treatment (one to four tumor localizations) were eligible for inclusion in the study. Child-Pugh score > B9, platelets count ≤ 50× 103/mm3, prothrombin index ≤ 50% and pregnancy were exclusion factors. Results - Between July 2001 and June 2004, 51 patients (13 women, 38 men, mean age 66 ± 9 years) were included and underwent 61 radiofrequency thermal ablation procedures for 82 hepatic lesions: hepatocarcinoma (N = 44), cholangiocarcinoma (N = 1), metastasic tumors (N = 37). Hospital morbidity and mortality were 11.5% and 2% respectively. Recurrence rate at 3 years was 20.6% . In multivariate analysis, only tumor size > 3 cm was correlated significantly with recurrence (P = 0.03). Actuarial 1- , 2- and 3- year survival rates in the hepatocarcinoma group (N = 31) were 84.7% , 57.7% and 34.6% respectively. Actuarial 1- , 2- and 3- year survival rates in the metastasis from colorectal adenocarcinoma group (N = 14) were 90% , 54% and 54% respectively (P = 0.72). Conclusion - Radiofrequency thermal ablation is an effective treatment for hepatic tumors measuring less than 3 cm. There is a low risk of complications and open surgery can be associated. However in the Absence of randomized studies comparing radiofrequency and surgery, respective indications cannot be defined in detail.
文摘分析颈背根神经射频热凝消融术联合内热针刺治疗颈源性头痛的临床疗效。方法 选择我院2022年1月-2022年12月颈源性头痛患者共116例,信封法随机分2组每组58例,对照组的患者给予颈背根神经射频热凝消融术治疗,观察组在该基础上增加内热针刺治疗。比较两组颈源性头痛缓解时间、治疗前后患者视觉模拟评分、颈椎活动度ROM评分、细胞因子 P 物质、白介素-6监测水平、总有效率、复发率。结果 观察组颈源性头痛缓解时间短于对照组,治疗后患者视觉模拟评分、颈椎活动度ROM评分、细胞因子 P 物质、白介素-6监测水平优于对照组,总有效率高于对照组,P<0.05。观察组复发率低于对照组,P<0.05。结论 颈背根神经射频热凝消融术联合内热针刺治疗对于颈源性头痛的治疗效果确切,可缓解颈椎疼痛和改善颈椎活动度,改善细胞因子水平,可有效降低疾病复发率。
