[Objective] This study aimed to investigate the mechanism of innovative montmorillonite for diarrhea treatment. [Method] Thirty healthy weanling piglets （Duroc x Landrace x Yorkshire） were randomly divided into five...[Objective] This study aimed to investigate the mechanism of innovative montmorillonite for diarrhea treatment. [Method] Thirty healthy weanling piglets （Duroc x Landrace x Yorkshire） were randomly divided into five groups and fed with basal diet, basal diet ＋ 1 g/kg innovative montmorillonite, basal diet ＋ 3 g/kg innovative montmorillonite, basal diet ＋ 5 g/kg innovative montmorillonite and basal diet ＋ 3 g/kg Bacillus subtilis microecologic agent, respectively. After four weeks, blood samples were collected via precaval vein, to detect the content of TFF3, NO and SOD in serum by ELISA kits. [Result] Compared with blank control group, the content of TFF3, NO and SOD in high-dose innovative montmorillonite group was extremely significantly increased, extremely significantly reduced and significantly in- creased, respectively; the content of TFF3 and NO in middle-dose innovative mont- morillonite group was significantly increased and significantly reduced, respectively. [Conclusion] Innovative montmorillonite may exert beneficial therapeutic actions on diarrhea by increasing TFF3 and SOD levels and decreasing NO level.展开更多
Tris(pentafluoroethyl)trifluorophosphate ([FEP])-based ionic liquids have been widely applied in many fields. For better understanding the properties of [FEP]-based ionic liquids, the interactions between 1-hexyl-3-me...Tris(pentafluoroethyl)trifluorophosphate ([FEP])-based ionic liquids have been widely applied in many fields. For better understanding the properties of [FEP]-based ionic liquids, the interactions between 1-hexyl-3-methylimidazolium ([hmim])[FEP] and small molecules were investigated by molecular dynamics simulations in this work. The small molecules are water, methanol and dimethyl ether. The united-atom (UA) force fields were proposed for methanol and dimethyl ether based on AMBER force field. The densities, enthalpies of vaporization, excess molar properties, and diffusion coefficients of the mixtures were calculated, as well as the microscopic structures characterized by radial distribution functions. Both of the results of the excess energies and microscopic properties show that the strongest interaction is between [hmim][FEP] and dimethyl ether, whereas the interaction between [hmim][FEP] and water is the weakest. Moreover, [hmim][FEP] is more hydrophobic than [hmim] hexafluorophosphate ([PF6]), and the three solutes are mainly distributed around [FEP] anion.展开更多
Adjusting the spacers between the electron-acceptor and the elector-donor is important to design organic ternary memory material but rarely reported. In this paper, two small molecules, ZIPGA and ZIPCAD with benzene r...Adjusting the spacers between the electron-acceptor and the elector-donor is important to design organic ternary memory material but rarely reported. In this paper, two small molecules, ZIPGA and ZIPCAD with benzene ring or triphenylamine as the spacers, were designed and synthesized to fabricate memory devices. The A1/ZIPGA/indium-tin oxide （ITO） device showed ternary characteristics, whereas A1/ZIPCAD/ITO had no obvious memory characteristics. Density functional theory calculation, X-ray diffraction （XRD） and atomic force microscopy （AFM） were employed to interpret the different memory properties. ZIPGA thin film has the closer intermolecular packing and flatter surface morphology than ZIPCAD film, which was favorable to the electron migration. This work demonstrates the importance of spacers and reveals that triphenylamine may be not a good spacer in design of new memory material.展开更多
基金Supported by Agricultural Science and Technology Independent Innovation Fund of Jiangsu Province(CX(13)5030)~~
文摘[Objective] This study aimed to investigate the mechanism of innovative montmorillonite for diarrhea treatment. [Method] Thirty healthy weanling piglets （Duroc x Landrace x Yorkshire） were randomly divided into five groups and fed with basal diet, basal diet ＋ 1 g/kg innovative montmorillonite, basal diet ＋ 3 g/kg innovative montmorillonite, basal diet ＋ 5 g/kg innovative montmorillonite and basal diet ＋ 3 g/kg Bacillus subtilis microecologic agent, respectively. After four weeks, blood samples were collected via precaval vein, to detect the content of TFF3, NO and SOD in serum by ELISA kits. [Result] Compared with blank control group, the content of TFF3, NO and SOD in high-dose innovative montmorillonite group was extremely significantly increased, extremely significantly reduced and significantly in- creased, respectively; the content of TFF3 and NO in middle-dose innovative mont- morillonite group was significantly increased and significantly reduced, respectively. [Conclusion] Innovative montmorillonite may exert beneficial therapeutic actions on diarrhea by increasing TFF3 and SOD levels and decreasing NO level.
基金supported by the National Natural Science Foundation of China (21106146, 20976004, 20903098 and 21073194)
文摘Tris(pentafluoroethyl)trifluorophosphate ([FEP])-based ionic liquids have been widely applied in many fields. For better understanding the properties of [FEP]-based ionic liquids, the interactions between 1-hexyl-3-methylimidazolium ([hmim])[FEP] and small molecules were investigated by molecular dynamics simulations in this work. The small molecules are water, methanol and dimethyl ether. The united-atom (UA) force fields were proposed for methanol and dimethyl ether based on AMBER force field. The densities, enthalpies of vaporization, excess molar properties, and diffusion coefficients of the mixtures were calculated, as well as the microscopic structures characterized by radial distribution functions. Both of the results of the excess energies and microscopic properties show that the strongest interaction is between [hmim][FEP] and dimethyl ether, whereas the interaction between [hmim][FEP] and water is the weakest. Moreover, [hmim][FEP] is more hydrophobic than [hmim] hexafluorophosphate ([PF6]), and the three solutes are mainly distributed around [FEP] anion.
基金supported by the National Natural Science Foundation of China (21176164, 21336005)the Chinese-Singapore Joint Project (2012DFG41900)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘Adjusting the spacers between the electron-acceptor and the elector-donor is important to design organic ternary memory material but rarely reported. In this paper, two small molecules, ZIPGA and ZIPCAD with benzene ring or triphenylamine as the spacers, were designed and synthesized to fabricate memory devices. The A1/ZIPGA/indium-tin oxide （ITO） device showed ternary characteristics, whereas A1/ZIPCAD/ITO had no obvious memory characteristics. Density functional theory calculation, X-ray diffraction （XRD） and atomic force microscopy （AFM） were employed to interpret the different memory properties. ZIPGA thin film has the closer intermolecular packing and flatter surface morphology than ZIPCAD film, which was favorable to the electron migration. This work demonstrates the importance of spacers and reveals that triphenylamine may be not a good spacer in design of new memory material.
