小型球铁件的收缩特点及其补缩工艺

根据国内外有关研究结果,阐述了球墨铸铁件冷却凝固过程中的体积变化规律,建立了球墨铸铁的收缩和膨胀模型,用以分析球墨铸铁小件的缩孔缩松形成机理。以轮毅铸件为例提出了防止缩孔缩松缺陷的工艺措施。

英国足球协会足球教学指南

本书系海因曼出版公司于1978年在伦敦出版,本刊现介绍其第二部分。

CSP引发内存封装技术的革命

简要介绍了几种内存芯片封装技术的特点。CSP 是内存芯片封装技术的新概念,它的出现促进内存芯片的发展和革新,并将成为未来高性能内存的最佳选择。

CSP引发内存封装技术的革命

本文简要介绍了几种内存芯片封装技术的特点。CSP是内存芯片封装技术的新概念,它的出现促进内存芯片的发展和革新。

适用于消费类电子产品的自动增益控制电路设计

本文简要介绍了几种内存芯片封装技术的特点。CSP是内存芯片封装技术的新概念,它的出现促进内存芯片的发展和革新,并将成为未来高性能内存的最佳选择。

可携式输注器

法国南锡Brabois医院急诊室的医生设计制造了一种可以携带的小型输注器,不用输液瓶,也不需使瓶保持高位。此输液器由一个密封盒组成,盒内有一个塑料袋,可装500毫升输注液。通过液态气给输液袋加压。液态气体通过一个开放阀进入密封盒,盒外放置一个小气筒。压力被调整到60分钟内输入500毫升的平均速度。输液的速度可以按需要调整,一个小型球状流速计装在管内,使用时将输注器固定在病人手臂上。

Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis

AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.

Meta-analysis of combined therapy for adult hepatitis B virus-associated glomerulonephritis

AIM: To investigate the efficacy and safety of combined antiviral and immunosuppressant therapy in adult hepatitis B virus-associated glomerulonephritis (HBVGN) patients. METHODS: A computerized literature search was carried out in the PubMed database, Embase, the Cochrane Library, Chinese BioMedical Literature on disc, Chinese Medical Current Contents, Chinese National Knowledge Infrastructure, Wanfang and VIP (Chinese Technological Journal of Database) to collect articles between June 1980 and December 2010 on therapy with immunosuppressants, e.g., glucorticosteroids, mycophenolate mofetil and leflunomide, combined with antivirals, e.g., interferon, lamivudine, entecavir and adefovir dipivoxil, in adult HBV-GN patients. The primary outcomes were remission of proteinuria, clearanceof HBV e-antigen, and elevation of serum albumin. The secondary outcomes were blood levels of alanine aminotransferase, serum creatinine, and HBV-DNA titer. Meta-analysis was performed using Review Manager 5.1. Fixed or random effect models were employed to combine the results after a heterogeneity test. The effects of the combined therapy were analyzed for different doses of glucorticosteroid and different types of HBV-GN. RESULTS: Twelve clinical trials with 317 patients were included. A significantly higher incidence of HBV-GN was found in male patients (relative risk = 2.40, 95% CI: 1.98-2.93). Combined therapy reduced the proteinuria significantly with a mean difference of 4.19 (95% CI: 3.86-4.53) and increased the serum albumin concentration significantly with a mean difference of -11.95 (95% CI: -12.97-10.93) without significant alterations of liver function (mean difference: 4.62, 95% CI: -2.55-11.79) and renal function (mean difference: 10.29, 95% CI: 0.14-20.45). No signif icant activation of HBV-DNA replication occurred (mean difference: 0.12, 95% CI: -0.37-0.62). There was no significant difference between the high dose glucorticosteroid group and the low dose glucorticosteroid group in terms of proteinuria remission (P = 0.76) and between different pathological types of HBV-GN [membranous glomerulonephritis (MN) vs mesangial proliferative glomerulonephritis, P = 0.68; MN vs membranoproliferative glomerulonephritis, P = 0.27]. CONCLUSION: Combined antiviral and immunosuppressant therapy can improve the proteinuria in HBVGN patients without altering HBV replication or damaging liver and renal functions.

Spatial Variability of Soil Organic Carbon in a Watershed on the Loess Plateau

Soil organic carbon (SOC) has great impacts on global warming, land degradation and food security. Classic statistical and geostatistical methods were used to characterize and compare the spatial heterogeneity of SOC and related factors, such as topography, soil type and land use, in the Liudaogou watershed on the Loess Plateau of North China. SOC concentrations followed a log-normal distribution with an arithmetic and geometric means of 23.4 and 21.3 g kg-1, respectively, were moderately variable (CV = 75.9%), and demonstrated a moderate spatial dependence according to the nugget ratio (34.7%). The experimental variogram of SOC was best-fitted by a spherical model, after the spatial outliers had been detected and subsequently eliminated. Lower SOC concentrations were associated with higher elevations. Warp soils and farmland had the highest SOC concentrations, while aeolian sand soil and shrublands had the lowest SOC values. The geostatistical characteristics of SOC for the different soil and land use types were different. These patterns were closely related to the spatial structure of topography, and soil and land use types.

Usefulness of a novel slim type Flush Knife-BT over conventional Flush Knife-BT in esophageal endoscopic submucosal dissection

To investigated the usefulness of a novel slim type ball-tipped FlushKnife (FlushKnife-BTS) over ball-tipped FlushKnife (FlushKnife-BT) in functional experiments and clinical practice.METHODSIn order to evaluate the functionality of FlushKnife-BTS, water aspiration speed, resistance to knife insertion through the scope, and waterjet flushing speed were compared between FlushKnife-BTS and BT. In clinical practice, esophageal endoscopic submucosal dissection (ESD) performed using FlushKnife-BTS or BT by an experienced endoscopist between October 2015 and January 2016 were retrospectively reviewed. The treatment speed and frequency of removing and reinserting the knife to aspirate fluid and air during ESD sessions were analyzed.RESULTSFunctional experiments revealed that water aspiration speed by the endoscope equipped with a 2.8-mm working channel with FlushKnife-BTS was 7.7-fold faster than that with conventional FlushKnife-BT. Resistance to knife insertion inside the scope with a 2.8-mm working channel was reduced by 40% with FlushKnife-BTS. The waterjet flushing speed was faster with the use of FlushKnife-BT. In clinical practice, a comparison of 6 and 7 ESD using FlushKnife-BT and BTS, respectively, revealed that the median treatment speed was 25.5 mm2/min (range 19.6-30.3) in the BT group and 44.2 mm2/min (range 15.5-55.4) in the BTS group (P = 0.0633). However, the median treatment speed was significantly faster with FlushKnife-BTS when the resection size was larger than 1000 m2 (n = 4, median 24.2 mm2/min, range 19.6-27.7 vs n = 4, median 47.4 mm2/min, range 44.2-55.4, P = 0.0209). The frequency of knife replacement was less in the BTS group (median 1.76 times in one hour, range 0-5.45) than in the BT group (7.02 times in one hour, range 4.23-15) (P = 0.0065).CONCLUSIONOur results indicate that FlushKnife-BTS enhances the performance of ESD, particularly for large lesions, by improving air and fluid aspiration and knife insertion during ESD and reducing the frequency of knife removal and reinsertion.

EFFECT OF CAPTOPRIL ON RENAL HEMODYNAMICS AND RENAL PROSTAGLANDINS IN EARLY TYPE Ⅱ DIABETIC PATIENTS WITH NORMO-OR MICROALBUMINURIA

In this study,we investigated the effect of captopril(CPT) on glomerular filtration rate(GFR),effective renal plasma flow(ERPF),filtration fraction(FF),urinary albumin excretion(UAE) and daily urinary excretion of thromboxane B2(TXB2) and 6-keto-prostaglandin F1a(6-keto-PGFla) in 29 normotensive non-insulin-dependent diabetes(NIDDM) patients without clinically discernible nephropathy.Before treatment,urinary excretion 6-keto-PGF1a was significantly increased(P<0.05) in 29 NIDDM patients compared with 25 health subjects matched for age and sex.The values of GFR and FF were significantly higher(P<0.01 and P<0.005,respectively) in NIDDM than in normal volunters,whereas ERPF was comparable in both groups.Meanwhile we observed that UAE of early NIDDM was increased before treatment.After CPT treatment,GFR,FF,UAE and urinary excretion of 6-keto-PGFla were significantly reduce(all P<0.005) compared with those of NIDDM before treatment. These data indicated that CPT is effective in lowering glomerular filtration pressure and ameliorating microalbuminuria in the normotensive early NIDDM.

Barter Trade Exchange to the Rescue of the Tourism and Travel Industry

South Africa＇s tourism and travel industry is a key sector in its economy as well as a significant job creator. The recent global economic turmoil is threatening the tourism industry; at the same time, global experts claim that tourism may be a key to overcoming economic difficulties and play a vital role in the green new deal. The purpose of the study is to introduce a new strategic option that has become increasingly attractive for troubled businesses-barter. While the study focuses on the advantages of this concept＇s recent refinements for South Africa＇s tourism and travel industry, its findings are also applicable to other countries. A survey of small and medium-sized enterprises （SME） from Europe and Turkey, as well as graduate students at an Israeli university, demonstrate the gap between familiarity with barter processes and their advantages and the actual scale of barter transactions in the supply chain, in order to enhance the economic performance of their tourism enterprises as well as the entire economy, providing evidence for the potential of adapting old proven concepts to the modem digital world.

Management Development Trends of Nowadays in Albania

Albanian business environment is defined by complexity, dynamism, uncertainty. In Albania, there are small and medium enterprises （businesses）. Although we have a high degree of business bankrupt, many businesses are reinforcing their competitive positions in market. In these conditions, a new appropriate organizational structure often plays a crucial role in managing the challenges. While the finn grows, at the same time grows the need for organization, involvement and leadership. In today＇s changing times, effective leadership is a key component of organizational success. Even if management is the key of operation and the standard operating procedures, our study shows that the manager always need leader＇s power. In today＇s global marketplace, organizations that strategically focus on building leadership capacity for the future will reap the benefits in the years to come. New trends in business development, of course have increased requirements for local managers. The organizations are under pressure to show return on investment for training and development. Although positive trends, problems which management is faced are more challenging than the degree of preparation and performance that they offer, so their qualitative qualification remains the continuous preoccupation as the role of our school is in this direction. From this point of view, education in distance can be considered as complementary approach and in some conditions as a worthy replacement of direct education, which still dominates educative systems in Albania.

Strategic and Organizational Evolutions of High-Tech SME on Global Market

The ＂OLI paradigm＂ of Dunning （1977） claims that firm internationalization is addressed toward the exploitation of home-based specific advantages. However, evidence shows that SMEs are increasingly internationalizing their activities in order to enrich their resource pool. In this regard, a reinterpretation of the OLI paradigm came out with a new perspective suggesting that ＂foreign direct investmenf＇ （FDI） is increasingly oriented toward asset augmentation. Correspondingly, the purpose of this theoretical paper is to suggest a set of principles that could inform on how global small and medium-sized enterprises grow in the international marketplace when investing abroad.

打球之乐

女儿、女婿常在节假日开着自己的汽车,把一家老老小小全带上,开到纽约东河中的罗得斯岛上去,那里有一个很大的高尔夫球场,球场辟出一个角,又建了个小型球场,专供初学者学习用的,也可供一个家庭娱乐之用。只要每人租借一副杆子、一个球。

Non-deterministic fatigue life analysis using convex set models

The non-probabilistic approach to fatigue life analysis was studied using the convex models-interval, ellipsoidal and multiconvex models. The lower and upper bounds of the fatigue life were obtained by using the second-order Taylor series and Lagrange multiplier method. The solving process for derivatives of the implicit life function was presented. Moreover, a median ellipsoidal model was proposed which can take into account the sample blind zone and almost impossibility of concurrence of some small probability events. The Monte Carlo method for multi-convex model was presented, an important alternative when the analytical method does not work. A project example was given. The feasibility and rationality of the presented approach were verified. It is also revealed that the proposed method is conservative compared to the traditional probabilistic method, but it is a useful complement when it is difficult to obtain the accurate probability densities of parameters.

Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D

Mutation of mevalonate kinase （MVK） is thought to account for most cases of hyperimmunoglobulinemia D syndrome （HIDS） with recurrent fever. However, its mechanism and the relationship between elevated serum immunoglobulin D （IgD） and the clinical features of HIDS are unclear. In this study, we generated by fusion PCR a vector to express high levels of chimeric secretory IgD （cslgD） specifically in the liver. We then generated seven founder lines of transgenic mice by co-microinjection, and verified them using genomic PCR and Southern blotting. We detected the expression of csIgD by reverse transcription PCR, quantitative PCR, western blotting, and enzyme-linked immunosorbent assays. We demonstrated that csIgD could be specifically and stably expressed in the liver. We used flow cytometry to show that overexpression of csIgD in the bone marrow and spleen cells had no effect on B cell development. Morphologic and anatomical observation of the transgenic mice revealed skin damage, hepatosplenomegaly, and nephromegaly in some transgenic mice; in these mice, pathological sections showed high levels of cell necrosis and protein-like sediments in the liver, spleen, and kidney. We demonstrated that the genomic insertion sites of the transgeues did not disrupt the MVK gene on mouse chromosome 5. This transgenic mouse will be useful to explore the pathogenesis of HIDS.