Naipaul's novels are real and acute, which reflect many countries and social realities, especially terrible lives and depressed emotions, including human interests, opinions, ideas, consciousnesses, self-acceptance, ...Naipaul's novels are real and acute, which reflect many countries and social realities, especially terrible lives and depressed emotions, including human interests, opinions, ideas, consciousnesses, self-acceptance, idea crisis, looking for identity, spiritual trouble, contradiction between religion and life, cultural conflict in colonized countries and post-colonized areas. Such novels are from actual realities, life facts, street matters with miscellaneous, vicissitudinous, and integrative skills and abilities.展开更多
Haruki Murakami is a serious belles-lettres writer with a title of petty bourgeois. With calm perspective, his writing points to the profound problems of human society, and also criticizes and analyses the history of ...Haruki Murakami is a serious belles-lettres writer with a title of petty bourgeois. With calm perspective, his writing points to the profound problems of human society, and also criticizes and analyses the history of World War II which is a closely guarded secret to most Japanese. The important topics of his literature are generally about the exposure of human nature under special time background, various deep problems accompanying with modern civilization, and the wounds brought to human by wars.展开更多
In China’s modernization drive, coordinated regional development and the building of a moderately prosperous society in all respects have been two mutually reinforcing dimensions. The three shifts of China’s princip...In China’s modernization drive, coordinated regional development and the building of a moderately prosperous society in all respects have been two mutually reinforcing dimensions. The three shifts of China’s principal social contradiction have responded to evolving needs of its regional development. Throughout various stages, the strategy of coordinated regional development has promoted the building of a moderately prosperous society in all respects in its concept formation, implementation and upcoming completion, which has reinforced regional coordination in return. In striving to achieve the goal of building a moderately prosperous society, China has increased its economic base, balanced its regional development, narrowed regional disparities, and increased equal access to essential public services.展开更多
AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting ce...AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC. METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis. RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type i myeloid (CD11c^+, CD11b^+, B220, CD8) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40, and had high endooltic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN). The majority (〉85%) of DC in the colon and MLN of IL2./ mice were type 1 myeloid, and expressed high levels of MHC class II, CD80, CD86, CD40, DEC 205, and CCR5 molecules and were of low endocytic activity consistent with mature DC. CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon.展开更多
AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis...AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed. RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved展开更多
Amitav Ghosh is one the most remarkable writers of the postmodernism era. He excelled in this era with his trend of magic realism. The Shadow Lines is a story told by a nameless narrator in recollection. It's a non l...Amitav Ghosh is one the most remarkable writers of the postmodernism era. He excelled in this era with his trend of magic realism. The Shadow Lines is a story told by a nameless narrator in recollection. It's a non linear tale told as if putting together the pieces of a jigsaw puzzle in the memory of the narrator. This style of writing is both unique and captivating; unfolding ideas together as time and space coalesce and helping the narrator understand his past better. Revolving around the theme of nationalism in an increasingly globalized world, Ghosh questions the real meaning of political freedom and the borders which virtually seem to both establish and separate. The novel traverses through almost seventy years through the memories of people, which the narrator recollects and narrates, giving their viewpoint along with his own. Though the novel is based largely in Kolkata, Dhaka, and London, it seems to echo the sentiments of whole Southeast Asia, with lucid overtones of Independence and the pangs of Partition.展开更多
Alice Ridout and Susan Watkins offers a best perspective in their book Doris Lessing: Border Crossings, to contemplate Lessing’s writing. In her 57-year publishing career, Lessing always crosses the borders: as a f...Alice Ridout and Susan Watkins offers a best perspective in their book Doris Lessing: Border Crossings, to contemplate Lessing’s writing. In her 57-year publishing career, Lessing always crosses the borders: as a feminist or anti-feminist, as a science fiction writer or a realist who lost her way, as a Marxist or a reactionary, as a British writer or a postcolonial one. Lessing’s border-crossing not only lies in her different genres of writing or in different novels, but even in a single comparatively traditional novel. The Summer Before the Dark is a representative work of Lessing’s women portrayal transition from focusing on their outside world exploration to on their inner world seeking. This essay tries to look at the content and form of the novel, and to illustrate that Lessing’s border-crossing is also fulfilled in one single novel. She successfully crosses the border of convention and innovation: conventional in content, while innovative in form.展开更多
This paper analyzes how the themes of magical realism and female divinity intersect in the novel The Puttermesser Papers (1997) by Cynthia Ozick. In the "Introduction", the writer defines magical realism and discu...This paper analyzes how the themes of magical realism and female divinity intersect in the novel The Puttermesser Papers (1997) by Cynthia Ozick. In the "Introduction", the writer defines magical realism and discusses its connections to Women's Studies. The next section, "The Bitter Butter Knife", discusses the protagonist's (Ruth Puttermesser) boring existence and pathetic attempts to connect to her Jewish ancestry. In "The Problematic Paradise", the author focuses on Puttermesser's attempts to take control of her life by creating the first female golem and the ups and downs of paradise. This author argues that the female protagonist of the novel utilizes magical realism as a tool of empowerment over personal oppression.展开更多
This study presents the use of the method of wavelet transform modulus maxima(WTMM) to detect boundaries of potential field sources.The boundaries of causative sources can be judged by calculating the local modulus ma...This study presents the use of the method of wavelet transform modulus maxima(WTMM) to detect boundaries of potential field sources.The boundaries of causative sources can be judged by calculating the local modulus maxima of wavelet coefficients at different scales.For the potential field data with noise,the detected boundaries at small scales are easy to be distorted by noise,however,at large scales,the noise can be suppressed greatly and presents more accurate boundary detection results.Therefore,we can get a better boundary judgment by considering the detected boundaries at all scales.Applying the WTMM method to synthetic models and a real data set of Meishan iron deposit,both get a good effect.展开更多
For applications requiring low-power,low-voltage and real-time,a novel analog VLSI implementation of continuous Marr wavelet transform based on CMOS log-domain integrator is proposed. Marr wavelet is approximated by a...For applications requiring low-power,low-voltage and real-time,a novel analog VLSI implementation of continuous Marr wavelet transform based on CMOS log-domain integrator is proposed. Marr wavelet is approximated by a parameterized class of function and with Levenbery-Marquardt nonlinear least square method,the optimum parameters of this function are obtained. The circuits of implementating Marr wavelet transform are composed of analog filter whose impulse response is the required wavelet. The filter design is based on IFLF structure with CMOS log-domain integrators as the main building blocks. SPICE simulations indicate an excellent approximations of ideal wavelet.展开更多
Sample size determination is commonly encountered in modern medical studies for two inde- pendent binomial experiments. A new approach for calculating sample size is developed by combining Bayesian and frequentist ide...Sample size determination is commonly encountered in modern medical studies for two inde- pendent binomial experiments. A new approach for calculating sample size is developed by combining Bayesian and frequentist idea when a hypothesis test between two binomial proportions is conducted. Sample size is calculated according to Bayesian posterior decision function and power of the most powerful test under 0-1 loss function. Sample sizes are investigated for two cases that two proportions are equal to some fixed value or a random value. A simulation study and a real example are used to illustrate the proposed methodologies.展开更多
文摘Naipaul's novels are real and acute, which reflect many countries and social realities, especially terrible lives and depressed emotions, including human interests, opinions, ideas, consciousnesses, self-acceptance, idea crisis, looking for identity, spiritual trouble, contradiction between religion and life, cultural conflict in colonized countries and post-colonized areas. Such novels are from actual realities, life facts, street matters with miscellaneous, vicissitudinous, and integrative skills and abilities.
文摘Haruki Murakami is a serious belles-lettres writer with a title of petty bourgeois. With calm perspective, his writing points to the profound problems of human society, and also criticizes and analyses the history of World War II which is a closely guarded secret to most Japanese. The important topics of his literature are generally about the exposure of human nature under special time background, various deep problems accompanying with modern civilization, and the wounds brought to human by wars.
文摘In China’s modernization drive, coordinated regional development and the building of a moderately prosperous society in all respects have been two mutually reinforcing dimensions. The three shifts of China’s principal social contradiction have responded to evolving needs of its regional development. Throughout various stages, the strategy of coordinated regional development has promoted the building of a moderately prosperous society in all respects in its concept formation, implementation and upcoming completion, which has reinforced regional coordination in return. In striving to achieve the goal of building a moderately prosperous society, China has increased its economic base, balanced its regional development, narrowed regional disparities, and increased equal access to essential public services.
基金Supported by the National Institutes of Health (RO1 AI41562 and PO1 RR12211) to SRC and PJF
文摘AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC. METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis. RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type i myeloid (CD11c^+, CD11b^+, B220, CD8) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40, and had high endooltic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN). The majority (〉85%) of DC in the colon and MLN of IL2./ mice were type 1 myeloid, and expressed high levels of MHC class II, CD80, CD86, CD40, DEC 205, and CCR5 molecules and were of low endocytic activity consistent with mature DC. CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon.
文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed. RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved
文摘Amitav Ghosh is one the most remarkable writers of the postmodernism era. He excelled in this era with his trend of magic realism. The Shadow Lines is a story told by a nameless narrator in recollection. It's a non linear tale told as if putting together the pieces of a jigsaw puzzle in the memory of the narrator. This style of writing is both unique and captivating; unfolding ideas together as time and space coalesce and helping the narrator understand his past better. Revolving around the theme of nationalism in an increasingly globalized world, Ghosh questions the real meaning of political freedom and the borders which virtually seem to both establish and separate. The novel traverses through almost seventy years through the memories of people, which the narrator recollects and narrates, giving their viewpoint along with his own. Though the novel is based largely in Kolkata, Dhaka, and London, it seems to echo the sentiments of whole Southeast Asia, with lucid overtones of Independence and the pangs of Partition.
文摘Alice Ridout and Susan Watkins offers a best perspective in their book Doris Lessing: Border Crossings, to contemplate Lessing’s writing. In her 57-year publishing career, Lessing always crosses the borders: as a feminist or anti-feminist, as a science fiction writer or a realist who lost her way, as a Marxist or a reactionary, as a British writer or a postcolonial one. Lessing’s border-crossing not only lies in her different genres of writing or in different novels, but even in a single comparatively traditional novel. The Summer Before the Dark is a representative work of Lessing’s women portrayal transition from focusing on their outside world exploration to on their inner world seeking. This essay tries to look at the content and form of the novel, and to illustrate that Lessing’s border-crossing is also fulfilled in one single novel. She successfully crosses the border of convention and innovation: conventional in content, while innovative in form.
文摘This paper analyzes how the themes of magical realism and female divinity intersect in the novel The Puttermesser Papers (1997) by Cynthia Ozick. In the "Introduction", the writer defines magical realism and discusses its connections to Women's Studies. The next section, "The Bitter Butter Knife", discusses the protagonist's (Ruth Puttermesser) boring existence and pathetic attempts to connect to her Jewish ancestry. In "The Problematic Paradise", the author focuses on Puttermesser's attempts to take control of her life by creating the first female golem and the ups and downs of paradise. This author argues that the female protagonist of the novel utilizes magical realism as a tool of empowerment over personal oppression.
文摘This study presents the use of the method of wavelet transform modulus maxima(WTMM) to detect boundaries of potential field sources.The boundaries of causative sources can be judged by calculating the local modulus maxima of wavelet coefficients at different scales.For the potential field data with noise,the detected boundaries at small scales are easy to be distorted by noise,however,at large scales,the noise can be suppressed greatly and presents more accurate boundary detection results.Therefore,we can get a better boundary judgment by considering the detected boundaries at all scales.Applying the WTMM method to synthetic models and a real data set of Meishan iron deposit,both get a good effect.
文摘For applications requiring low-power,low-voltage and real-time,a novel analog VLSI implementation of continuous Marr wavelet transform based on CMOS log-domain integrator is proposed. Marr wavelet is approximated by a parameterized class of function and with Levenbery-Marquardt nonlinear least square method,the optimum parameters of this function are obtained. The circuits of implementating Marr wavelet transform are composed of analog filter whose impulse response is the required wavelet. The filter design is based on IFLF structure with CMOS log-domain integrators as the main building blocks. SPICE simulations indicate an excellent approximations of ideal wavelet.
基金This research is supported by the National Natural Science Foundation of China under Grant Nos. 10761011, 10961026, Ph.D. Special Scientific Research Foundation of Chinese University under Grant No. 20060673002, and by program for New Century Excellent Talents in University (NCET-07-0737).
文摘Sample size determination is commonly encountered in modern medical studies for two inde- pendent binomial experiments. A new approach for calculating sample size is developed by combining Bayesian and frequentist idea when a hypothesis test between two binomial proportions is conducted. Sample size is calculated according to Bayesian posterior decision function and power of the most powerful test under 0-1 loss function. Sample sizes are investigated for two cases that two proportions are equal to some fixed value or a random value. A simulation study and a real example are used to illustrate the proposed methodologies.