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小插入与小缺失突变律:频数与碱基数的平方成反比 被引量:3
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作者 李凯 《南华大学学报(医学版)》 2006年第1期1-2,9,共3页
在基因突变中,小突变较大突变发生率要高。其中,小插入与小缺失突变的频率随突变碱基数的增加而递减。通过对HGMD的数据分析,这一突变频数的递减具有与小插入和小缺失突变碱基数的平方成反比的趋势。
关键词 小插入 小缺失 基因突变
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同时含有插入与缺失的复杂突变的起源
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作者 肖莉 周翠兰 +3 位作者 殷宇芳 陈成利 廖端芳 李凯 《南华大学学报(医学版)》 2007年第5期782-783,共2页
根据提出的突变规律,分别从复杂插入—缺失突变的数量结构特征和序列结构特征两方面,对人类基因组突变数据库中同时含有插入与缺失的复杂突变进行分析,并探讨其意义。
关键词 小插入 小缺失 复杂突变
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Effects of Homologous Genome 7 on Gas Exchange and Chlorophyll Fluorescence Parameters of Wheat 被引量:4
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作者 魏爱丽 畅志坚 +1 位作者 王会琴 詹海仙 《Agricultural Science & Technology》 CAS 2010年第1期25-27,共3页
[Objective]To study the effects of homologous chromosomes 7 (7A,7B and 7D) on wheat photosynthesis and provide theoretical basis for breeding high photosynthetic efficiency wheat by genetic,physiological and biochem... [Objective]To study the effects of homologous chromosomes 7 (7A,7B and 7D) on wheat photosynthesis and provide theoretical basis for breeding high photosynthetic efficiency wheat by genetic,physiological and biochemical means. [Method]The Triticum asetivum cultivar Chinese Spring wheat and nullisomic wheat (N7A,N7B and N7D) were planted in greenhouse. The photosynthetic indexes were determined at early filling stage. [Result]The photosynthetic rate (Pn),stomatal conductance (Gs),primary photochemical efficiency (Fv/Fm),actual chemical efficiency of photosystem II (ФPS II) and apparent electron transfer rate of photosystem II (ETR) were significantly lower in the N7A and N7B than in the Chinese Spring (P0.05). The photosynthetic rate and stomatal conductance was significantly lower in the N7D than in the Chinese Spring (P0.05). The Fv/Fm,ФPS II,ETR of N7D were higher than that of the Chinese Spring without significant difference. [Conclusion]The homologous chromosomes 7A and 7B have positive effects on photosynthetic rate and have relationship with stomatal conductance and photoreaction (chlorophyll fluorescence parameters). The homologous chromosome 7D has negative effects on photosynthetic rate,which is mainly related to stomatal conductance rather than photoreaction. 展开更多
关键词 Chromosome deletion Triticum asetivum Photosynthetic characteristics Fluorescence parameters
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Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders 被引量:3
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作者 Krishnappa Venkatesh Marta Cohen +6 位作者 Clair Evans Peter Delaney Steven Thomas Christopher Taylor Ashraf Abou-Taleb Ralf Kiesslich Mike Thomson 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第18期2214-2219,共6页
AIM: To evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to his... AIM: To evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to histology.METHODS: Forty-four patients (19 female) median age 10.9 years (range 0.7-16.6 years) with suspected or known GI pathology underwent esophago-gastro- duodenoscopy (OGD) (n = 36) and/or ileocolonoscopy (IC) (n = 31) with CLE using sodium fluorescein and acriflavine as contrast agents. Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists, respectively.RESULTS: Duodenum and ileum were intubated in all but one patient undergoing OGD and IC. The median procedure time was 16.4 min (range 7-25 rain) for OGD and 27.9 min (range 15-45 min) for IC. A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures, and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 procedures.Confocal images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis, Helicobacter pylori gastritis, celiac disease, inflammatory bowel disease, colonic heterotopia, and graft versus host disease.CONCLUSION: CLE offers the prospect of targeting biopsies to abnormal mucosa, thereby increasing diagnostic yield, reducing the number of biopsies, decreasing the burden on the histopathological services, and reducing costs. 展开更多
关键词 Confocal laser endomicroscopy HISTOLOGY PEDIATRIC Gastrointestinal mucosa Gastrointestinaldisorders
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