石门—小阶段采场系统在严家湾煤矿的应用

针对急倾斜厚度不稳定煤层,严家湾煤矿尝试运用石门—小阶段开采系统建立生产系统,该开采系统安全可靠,在复杂地质条件下通过降低井巷工程量,取得了良好社会和经济效益。

煤与瓦斯突出煤层小阶段联合开采的实践

介绍了煤与瓦斯突出煤层小阶段联合开采的实践与探索,分析了小阶段联合开采节约大量工程资金、提高单产效率约60%、节约间歇时间6~7个月等优越性,并提出结合矿井安全生产管理水平、装备水平、工人操作技能等因素因地制宜采用小阶段联合开采的建议。

赵各庄矿极复杂区域保护煤柱留设数值模拟研究

针对赵各庄急倾斜、大断层和采空区下极复杂区域煤层开采中煤柱留设宽度问题,理论分析了极复杂区域煤柱留设条件:一是作为断层保护煤柱,二是作为9煤老空区保护煤柱。将断层煤柱划分为采空区一侧煤体塑性区、有效隔水煤柱的弹性区和断层处煤体裂隙带三个区域,分别计算煤柱宽度。在理论分析和数值模拟基础上,建立了极复杂区域老空区下急倾斜煤层开采保护煤柱数值模型,模拟分析了工作面无煤柱、煤柱距离32m和64m三种不同情况开采时工作面围岩应力变化、围岩位移变化和塑性破坏区等情况,直观分析解释煤柱留设的依据。结合现场地质条件,计算赵各庄3839区域煤层开采煤柱留设宽度为66.2m。

新安煤矿提高煤炭采出率的方法与实践

介绍了新安煤矿采用提高开采上限,利用井下巷探、钻探等手段探明地质构造,留设小阶段煤柱,增加工作面倾斜长,布置转向工作面和加强工作面技术管理等手段和方法,提高煤炭采出率,取得了很好的效果。

急倾斜煤层巷道布置特点

针对义安煤矿急倾斜煤层特点 。

伪斜柔性掩护支架采煤法的应用及创新

拾屯煤矿9煤层原一直采用小阶段爆破采煤法开采,2015年开始试验伪倾斜柔性掩护支架采煤法,推广应用至今,取得了掘进率低、产量增加、煤质提高、材料消耗下降、资源回收率高、安全性可靠的效果。

Effect of carbon source on growth and lipid accumulation in Chlorella sorokiniana GXNN01

Heterotrophic culture of microalgae to develop methods of increasing biomass productivity and storage lipids has brought new insight to commercial biodiesel production. To understand the relationship between heterotrophy and lipid production, the effects of carbon sources on the growth and lipid accumulation of Chlorella sorokiniana GXNN01 was studied. The alga exhibited an increased growth rate in response to the addition of carbon sources, which reached the stationary phase after 48 h at 30℃. In addition, glucose and NaAc had a significant effect on the lipid accumulation during the early-stationary phase. Specifically, the lipid content was 0.237±0.026 g ·g^-1 cell dry weight and 0.272±0.041 g Ll when glucose was used as the carbon source, whereas the lipid content reached 0.287±0.018 g ·g^-1 cell dry weight and 0.2884-0.008 g Lz when NaAc was used as the carbon source. The neutral lipid content was found to first decrease and then increase over time during the growth phase. A glucose concentration of 20 mmol L^-1 gave the maximal lipid yield and the optimum harvest time was the early-stationary phase.

Stationary Wave Activity Associated with the East Asian Winter Monsoon Pathway

The pathway of the East Asian winter monsoon(EAWM) that usually leads to the out-of-phase pattern of surface air temperature between northern and southern East Asia is an important feature in the variability of the EAWM besides its strength.Using the European Centre for Medium-Range Weather Forecasts 40-year(ERA40) reanalysis dataset,this study investigates the pathway-related stationary wave activity to explore the mechanism of the interannual variations in the EAWM pathway.It reveals that when the southern pathway of the EAWM is strong,the phase of the climatological stationary wave tends to be shifted westward significantly in both the horizontal and vertical directions by an anomalous wavenumber 2 pattern at mid-latitudes,whereas the changes are relatively small in the subtropics.The horizontal changes in the stationary wave phase facilitate a north-south-oriented East Asian trough in the middle troposphere that eventually produces the strong southern pathway of the EAWM.The vertical changes in the stationary wave,in contrast,feature a westward-tilted phase line with height over the North Pacific,indicating enhanced upward propagation of waves into the stratosphere.This result suggests that the phase of stationary waves at mid-latitudes dominate the interannual variations in the EAWM pathway.Moreover,it supports our previous interpretation of the possible role of the North Pacific sea surface temperature(SST) in the EAWM pathway variability.It also implies that the excitation of anomalous mid-latitude stationary waves may be the key in the response of the EAWM pathway to the North Pacific SST.

Embryology of Maldives Clownfish, Amphiprion nigripes (Amphiprioninae)

This study investigated the embryonic development of Maldives clownfish Amphiprion nigripes under natural conditions (28 - 30℃) at a lagoon of Agatti Island, Lakshadweep, India. The newly deposited fish egg was capsule-shaped and orange-red, with a (0.73 ± 0.04) mm3 yolk containing 5 - 10 fat globules. The embryonic development of fertilized eggs was divided into 26 stages and the time elapsing for each stage was recorded. Results showed that the cleavage was rapid, with the first division observed 1 h 20 min after fertilization. Blastulation occurred 4 h later, followed by gastrulation 12 h after fertilization, with a yolk volume of (0.61 ± 0.06) mm3. The organogenesis process started 22 h after fertilization when the blastopores closed and notochord formation began. The embryonic stage was recorded 24 h later, with the appearance of forebrain, midbrain, hindbrain, melanophores on yolk-sac and 22 somites, and a decreased yolk volume of (0.54 ± 0.08) mm3. Other organs developed well 31 h after fertilization, whereas the heart started beating and blood circulation began 78 h later. Red pigmentation (erytrophores) appeared 96 h after fertilization, with a small yolk volume of (0.22 ± 0.02) mm3. Mouth developed well and eyes were noticeable 120 h later, with head, pectoral fin and tail frequently moving 144 h after fertilization. The embryo reached the pre-hatching stage 168 h later and started to hatch after 170 - 180 h incubation. This study first detailed the embryonic development and yolk absorption of A. nigripes under natural conditions.

The prescription rule analysis of the New Theory on Spleen Dampness Syndrome by Academician TONG Xiaolin

Objective To analyze the basic characteristics,drug features,prescription rules,and drug-symptom relationships of patients in the splenic deficiency and impairment stage,by data mining of medical records under the New Theory on Spleen Dampness Syndrome(Pi Dan Xin Lun,《脾瘅新论》).Methods Medical records listed in the“New Theory on Spleen Dampness Syndrome-Under-standing and Treatment of Metabolic Syndrome from the Perspective of Traditional Chinese Medicine”,and which were diagnosed with the spleen dampness syndrome at the splenic de-ficiency and impairment stage,during January 2004 and December 2016 were selected.These patients’data,including basic information,clinical symptoms,laboratory examination res-ults,traditional Chinese medicine(TCM)and western medicine diagnoses,treatment meth-ods,prescriptions,etc.,were collected.The collected data were subsequently compiled into a medical record database using the Epidata 3.1 data management software,followed by the use of Apriori algorithm provided in the SPSS Modeler 14.2 statistical software to investigate the association rules between drug-drug,drug-symptom,and drug-western medicine indices.Results(i)A total of 51 medical records were included,involving 17 types of syndromes.Among them,the top three with frequency≥3 included“Phlegm and blood stasis,and thoracic obstruction”“Deficiency-weakness of the spleen Qi,and static blood blocking collat-erals”,and“Deficiency-weakness of the spleen Qi,and static blood blocking collaterals”.Al-ternatively,of the 14 treatment methods,the top three treatments with frequency of≥3 in-cluded“Activating Yang and eliminating turbidity,and removing phlegm and dredging chan-nel blockage”“Strengthening the spleen and benefiting Qi,and eliminating phlegm to activ-ate the channels”,and“Warming Yang and benefiting Qi,and expelling cold to remove ob-structions”.Among the 15 prescriptions,the top three used with frequency≥3 included Huangqi Guizhi Wuwu Tang(黄芪桂枝五物汤),Gualou Xiebai Banxia Tang(瓜蒌薤白半夏汤),and Ganjiang Huangqin Huanglian Renshen Tang(干姜黄芩黄连人参汤).Lastly,of the 83 drugs used for a total of 476 times,those with frequency≥15 included Huanglian(Coptid-is Rhizoma),Huangqi(Astragali Radix),Jiudahuang(Wine-processed Rhei Radix et Rhizoma),Jixueteng(Spatholobi Caulis),Shengjiang(Zingiberis Rhizoma Recens),Huangqin(Scutellariae Radix),and Guizhi(Cinnamomi Ramulus).(ii)For the drug-drug associations,under the criteria of support≥15%and confidence=100%,seven second-order association rules,seven third-order rules,and six fourth-order roles were identified.The top-ranking rule of each was“Huangqin(Scutellariae Radix)→Huanglian(Coptidis Rhizoma)”“Ganjiang(Zingiberis Rhizoma)+Huangqin(Scutellariae Radix)→Huanglian(Coptidis Rhizoma)”,and“Baishao(Paeoniae Radix Alba)+Guizhi(Cinnamomi Ramulus)+Jixueteng(Spatho-lobi Caulis)→Huangqin(Scutellariae Radix)”,respectively.Alternatively,the drug-symptom associations were analyzed under the criteria of support≥5%and confidence=100%,which derived eight second-order association rules,31 third-order rules,and 30 fourth-order rules.The top-ranking association rule of each order was“Huangqi(Astragali Radix)→Limb ed-ema”“Guizhi(Cinnamomi Ramulus)+Jixueteng(Spatholobi Caulis)→Limb numbness and pain”,and“Guizhi(Cinnamomi Ramulus)+Jixueteng(Spatholobi Caulis)+Huangqi(As-tragali Radix)→Limb numbness and pain”,respectively.Similarly,the drug-western medi-cine index associations were investigated under the criteria of support≥5%and confidence=100%,and five second-order association rules,16 third-order rules,and 16 fourth-order rules were identified.In this category,the top-ranking association rule of each order was“Qinpi(Fraxini Cortex)→Uric acid”“Huanglian(Coptidis Rhizoma)+Ganjiang(Zingiberis Rhizoma)→Glycated hemoglobin”,and“Huanglian(Coptidis Rhizoma)+Ganjiang(Zing-iberis Rhizoma)+Huangqin(Scutellariae Radix)→Glycated hemoglobin”,respectively.Conclusion Through association rule mining,this study objectively and quantitatively demonstrated the drug-drug,drug-symptom,and drug-physicochemical index associations of patients with the spleen dampness syndrome at the splenic deficiency and impairment stage treated by Academician TONG Xiaolin.The results indicated that treatment for these patients adopted the“state-target”syndrome differentiation method.The drug combination was characterized by“small prescriptions”,targeting both the patient’s symptoms and signs(syndrome target)and western medicine indices(treatment target).This study could provide references for future research on the academic thoughts and medical experience of Academi-cian TONG Xiaolin.

Clinical study of docetaxel-vinorelbine as second-line chemotherapy in advanced non-small cell lung cancer

Objective： To evaluate the efficacy and toxicity of docetaxel and vinorelbine as second-line chemotherapy in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： 48 histologically or cytologically confirmed NSCLC patients with progressive or recurrent disease after first-line treatment were treated with docetaxel and vinoretbine. The chemotherapy included vinorelbine （25 mg/m^2） on days 1,5 and docetaxel （60 mg/m^2） on day 1. The treatment was repeated every 3 weeks. Patients receiving at least two cycles were evaluated for efficacy and toxicity. Results： Of 48 patients, 1 patient achieved complete response and 16 achieved partial response. Overall response rate for all 48 patients was 35.4% （17/48）. Main hematologic toxicities included neutropenia （60.4%） and febrile neutropenia （29.2%） and non-hematologic toxicities were mild. Conclusion： The combination of docetaxel-vinorelbine as second-line chemotherapy is an effective regimen with manageable toxicity for the treatment of advanced NSCLC. Further studies may confirm these results.

Effect of Deficit Irrigation at Different Growth Stages on Wheat Growth and Yield

In order to evaluate the effect of deficit irrigation at various growth stages on wheat growth and yield, a field experiment was conducted in the 2008-2009 growing season based on the completely randomized block with four replications at the experimental farm of the College of Agriculture, Shiraz University, Shiraz, Iran, located at Badjgah. Treatments involved 13 irrigation regimes which applied in stem elongation, heading and grain filling growth stages. The highest seed yield （4,333 kg-ha-1） and the lowest ones （1,377 kg＇hal） were obtained from T1 （100% field capacity （FC） in all growth stages） and T13 （50% FC in all growth stages）, respectively. With limitation in water amount seed yield was diminished, but this trend was not significant at T4 （100%, 100% and 50% FC） and TI 1 （100%, 100% and 75~/0 FC）. Stepwise regression results revealed that, seed number per spike had the largest contribution （partial R2 = 0.72） in seed yield variation. Also at TI, T4, and TI 1 treatments （well water treatments） as well as TI3 （sever stress） head number m2 contribute most in seed yield determination （partial R2 = 0.96）. It can be concluded that water shortage during the grain filling period and its allocation to the other consecutive crop, can increase crop production in southern regions of Iran.

基于智力城镇化的特色小镇产业培育探索——以辽宁通远堡镇为例

我国城镇化正处于劣势的体力城镇化阶段,特色小镇作为新型城镇化的主力军,体力化威胁仍不可避免。为缓解特色小镇体力化困境,文章基于智力城镇化的相关理论,以辽宁通远堡镇为例,围绕特色产业展开智力化培育的探索。结合链式产业思维,以智力投入、智力主体、智力产出三大环节为基础,以智力要素创新性地打造智力链条,构建可持续的特色产业,带动城镇化转型升级,以期为辽宁省乃至全国特色小镇培育提供借鉴。

FACE-TO-FACE AND SYNCHRONOUS ELECTRONIC DISCUSSION AS PREWRITING ACTIVITY IN THE FOREIGN LANGUAGE WRITING CLASS

One of the main findings of computer-mediated communication study in recent years is that it has anequalizing effect among student participation in class. Face-to-face discussions tend to be relatively unbalanced,with the teacher or a few participants dominating the floor; however, computer-mediated communicationfeatures more balanced participation, with participants sharing the floor more equally. According to somestudies, second and foreign language teachers have also claimed that electronic communication has been provedto be an equalizer in their classrooms. Besides, some researches find that the formality and complexity oflanguage in electronic discussion might be an excellent medium for prewriting work since it could serve as abridge from spoken interaction to written composition. This study aims to prove these claims throughcomparing the performances of student participation in the traditional face-to-face prewriting small groupdiscussions and those in the synchronous computer-mediated communication mode. The findings show out atendency toward more equal participation in computer-mediated communication mode. The study alsodiscovers that the language students used in the electronic prewriting discussion and in the first drafts composedafter the discussion is more formal and complex lexically and syntactically than the language they used in face-to-face mode. The comparison of the first drafts which were finished separately after the two modes ofdiscussion by individual student demonstrate, however, there is not obvious differences among the twocategories of first drafts concerning the content of writing.

Spatiotemporal differentiation of changes in wheat phenology in China under climate change from 1981 to 2010

Phenology is a reliable biological indicator for reflecting climate change. An examination of changes in crop phenology and the mechanisms driving them is critical for guiding regional agricultural activities in attempts to adapt to climate change. Due to a lack of records based on continuous long-term observation, studies on changes in multiple consecutive phenological stages throughout a whole growing season on a national scale are rarely found, especially with regard to the spatiotemporal differentiation of phenological changes. Using a long-term dataset(1981-2010) of wheat phenology collected from 48 agro-meteorological stations in China, we qualified the spatiotemporal changes of 10 phenological stages as well as the length of wheat growth phases. Results showed that climate and wheat phenology changed significantly during the growing seasons from 1981 to 2010. On average, on a national scale, dates of sowing(0.19 d a-1), emergence(0.06 d a-1), trefoil(0.05 d a-1), and milk ripe(0.06 d a-1) showed a delaying trend, whereas dates of tillering(-0.02 d a-1), jointing(-0.15 d a-1),booting(-0.21 d a-1), heading(-0.17 d a-1), anthesis(-0.19 d a-1), and maturity(-0.10 d a-1) showed an advancing trend.Furthermore, the vegetative growth phase and growing season were shortened by 0.23 and 0.29 d a-1, respectively, whereas the reproductive growth phase was lengthened by 0.06 d a-1. Trends in dates of phenological stages or length of growing phases varied across wheat-planting regions. Moreover, spatiotemporal differentiation of sensitivity in growing season length(GSL) to variations in climatic factors during the growing season between spring and winter wheat were remarkable. The GSL of spring(winter) wheat decreased(increased) with an increase in average temperature during the growing season. In all wheat-planting regions, the GSL increased with the increasing of total precipitation and sunshine duration during the growing season. In particular, the sensitivity of GSL to precipitation for spring wheat was weaker than for winter wheat, while the sensitivity of GSL to sunshine duration for spring wheat was stronger than for winter wheat. Recognition of the spatiotemporal differentiation of phenological changes and their response to various climatic factors will provide scientific support for decision-making in agricultural production.

Significant variations in alternative splicing patterns and expression profiles between human-mouse orthologs in early embryos

Human and mouse orthologs are expected to have similar biological functions; however, many discrepancies have also been reported. We systematically compared human and mouse orthologs in terms of alternative splicing patterns and expression profiles. Human-mouse orthologs are divergent in alternative splicing, as human orthologs could generally encode more isoforms than their mouse orthologs. In early embryos, exon skipping is far more common with human orthologs, whereas constitutive exons are more prevalent with mouse orthologs. This may correlate with divergence in expression of splicing regulators. Orthologous expression similarities are different in distinct embryonic stages, with the highest in morula. Expression differences for orthologous transcription factor genes could play an important role in orthologous expression discordance. We further detected largely orthologous divergence in differential expression between distinct embryonic stages. Collectively, our study uncovers significant orthologous divergence from multiple aspects, which may result in functional differences and dynamics between human-mouse orthologs during embryonic development.