小青龙加味汤治疗喉源性咳嗽的临床疗效观察

目的:观察小青龙加味汤治疗慢性喉源性咳嗽的疗效。方法:将100例喉源性咳嗽患者随机分为两组,对照组50例,采用咳特林2粒/次,每日3次口服治疗;观察组50例,采取小青龙加味汤口服,每日1剂中晚温服,5天为1疗程。结果:观察组总有效率90%,对照组总有效率36%,两组比较差异有显著性(P<0.05)。结论:小青龙加味汤治疗慢性喉源性咳嗽临床疗效确切,值得进一步推广使用。

小青龙汤加减合右美沙芬片治疗慢性支气管炎的临床疗效分析

目的:为了研究小青龙加减联合右美沙芬片治疗慢性支气管炎的临床疗效,我们选取了2022年3月到6月的60名患者,按1到60号对患者进行排序,采用随机抽样法,偶数为研究组,奇数为对照组。研究组采用小青龙汤加减治疗,对照组采用右美沙芬片治疗。研究两组的治疗效果。结果发现:研究组治疗有效率为96.7%,对照组治疗有效率为90.0%,研究组显然高于对照组。两组对比差异有统计学意义(P Objective: To study the clinical efficacy of modified Xiaoqinglong decoction combined with dextromethorphan tablets in chronic bronchitis, we selected 60 patients from March to June 2022, ranked patients by 1 to 60, using random sampling method, even number for the study group and odd number for the control group. The study group was treated with modified Xiaoqinglong decoction, and the control group was treated with dextromethorphan tablets. To study the treatment effect in both groups. The results found that the effective rate of the study group was 96.7%, and the control group was 90.0%, and the study group was obviously higher than the control group. The difference between the two groups was statistically significant (P < 0.05). Before treatment, there was no significant difference in symptoms such as cough, expectoration, wheezing, fever, headache between the two groups. After treatment, the study group and the control group improved significantly, but the study group improved more significantly. The clinical symptoms disappeared early after treatment, and the difference compared with the control group was statistically significant (P < 0.05). Conclusion: Modified Xiaoqinglong decoction is highly effective in treating chronic bronchitis, and cough, expectoration, wheezing, fever and cold, headache and other symptoms disappear quickly, which is more effective than the control group, making it worthy of widespread promotion in clinical practice.

穴位敷贴联合加味小青龙汤治疗支气管哮喘急性发作期临床疗效

目的分析穴位敷贴联合加味小青龙汤对支气管哮喘急性发作期患者气道重塑及炎性细胞因子水平的影响。方法选取本院2019年1月—2020年1月收治的68例支气管哮喘急性发作期患者,随机分为参照组(34例)、治疗组(34例)。参照组实施西医治疗,治疗组在西医治疗基础上予以穴位敷贴联合加味小青龙汤治疗,两组均连续治疗1周。观察两组治疗1周后的治疗优良率,比较两组治疗前、治疗1周后的中医症状评分、肺功能及血生化指标。结果治疗1周后,治疗组的治疗优良率为94.12%,高于参照组的73.53%(P<0.05)。治疗1周后,两组肺部哮鸣音、咳嗽、咯痰、喘息评分及血清嗜酸性粒细胞趋化因子(Eotaxin)、转化生长因子-β1(TGF-β1)、白细胞介素-8(IL-8)水平均低于治疗前,且治疗组低于参照组(P<0.05)。治疗1周后,两组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)水平高于治疗前,且治疗组高于参照组(P<0.05)。结论穴位敷贴联合加味小青龙汤治疗支气管哮喘急性发作期可降低患者血清Eotaxin、TGF-β1、IL-8水平,有效抑制气道重塑及炎症反应,进而改善其中医症状及肺功能,临床疗效显著。

小青龙汤及其加味方对变应性鼻炎大鼠IL-4和IL-4mRNA表达的影响

目的:观察小青龙汤及其加味方对变应性鼻炎(AR)大鼠血浆IL4含量和脾细胞IL4mRNA表达水平的影响。方法:采用卵蛋白全身致敏与局部攻击方法制作AR大鼠模型,观察小青龙汤加味治疗后血浆IL4含量和脾细胞IL4mRNA的表达。结果:模型组血浆IL4含量和脾细胞IL4mRNA的表达明显升高,小青龙汤加味治疗组血浆IL4含量和脾细胞IL4mRNA的表达明显降低,小青龙汤加味治疗组优于小青龙汤治疗组。结论:小青龙汤加味治疗AR的作用途径之一可能是通过降低IL4mRNA的表达水平,间接降低IL4含量,从而减轻鼻粘膜变应性炎症。