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并指(趾)短指(趾)少指(趾)节畸形家系报告 被引量:1
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作者 司宝敏 张卫红 周曾娣 《中国优生与遗传杂志》 1998年第1期84-8,共1页
并指(趾)短指(趾)和缺指(趾)病在人类为多见的遗传性疾病,而短指(趾)少指(趾)节则较为少见。我们在少数民族遗传病调查中,对云南边远山区德昂族一个并指(趾)少指(趾)节畸形家系进行调查,追溯4代,发现患者2人,现报告如下。
关键词 少指 先天性畸形 遗传性疾病 骨骼
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短指少指(趾)节病与IHH基因突变研究
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作者 陈敬焕 陈迪钊 《怀化医专学报》 2002年第1期22-24,共3页
目的:探讨短指少指(趾)节病与IHH基因突变之间的关系;探讨短指少指(趾)节病的致病原因。方法:(1)家庭调查;(2)X线检查;(3)皮纹检查;(4)取外周血样品,标准方法提取DNA,聚合酶链反应,聚合酶链反应产物测序。结果在第... 目的:探讨短指少指(趾)节病与IHH基因突变之间的关系;探讨短指少指(趾)节病的致病原因。方法:(1)家庭调查;(2)X线检查;(3)皮纹检查;(4)取外周血样品,标准方法提取DNA,聚合酶链反应,聚合酶链反应产物测序。结果在第300位碱基(位于外显子1)上发生突变(C→A)。导致第100位的天冬氨酸变成谷氨酸。IHH基因突变减少了一个Acil位点。结论:编码Indian hedsehog蛋白的基因突变导致了短指少指(趾)节病。 展开更多
关键词 少指(趾)节病 基因突变 编码Indian hedsehog蛋白 聚合酶链反应
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少指责多自责
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作者 薄俊元 《政工学刊》 1998年第2期18-18,共1页
少指责多自责薄俊元领导机关的同志下基层归来,不免都要慨叹指责一番,一言以蔽之:基层工作落实不好。有的还形象地把这种状况概括为上紧下松、上细下粗和上急下不急。诚然,基层有些工作不落实是事实,其主要原因不外乎一些基层干部... 少指责多自责薄俊元领导机关的同志下基层归来,不免都要慨叹指责一番,一言以蔽之:基层工作落实不好。有的还形象地把这种状况概括为上紧下松、上细下粗和上急下不急。诚然,基层有些工作不落实是事实,其主要原因不外乎一些基层干部责任心不强,工作不到位。但是,孰不... 展开更多
关键词 领导机关工作 基层工作 少指 领导作风 抓基层 工作落实 基层干部 实际承受能力 领导方法 主观方面
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少指缺掌并足裂畸形一家系调查及其病因研究 被引量:1
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作者 胡周军 余晓芬 +3 位作者 李气环 张爱菊 邓曦 张爱英 《中华医学遗传学杂志》 CAS CSCD 2004年第5期482-484,共3页
目的 研究先天性少指缺掌并足裂畸形一家系患者的临床表现及其致病原因。方法 在患者家系调查的基础上 ,设立正常对照组与患者组 ,应用聚合酶链反应技术对两组的 P6 3基因第 5~ 8外显子基因组 DNA测序分析。结果 体检发现 ,患者双... 目的 研究先天性少指缺掌并足裂畸形一家系患者的临床表现及其致病原因。方法 在患者家系调查的基础上 ,设立正常对照组与患者组 ,应用聚合酶链反应技术对两组的 P6 3基因第 5~ 8外显子基因组 DNA测序分析。结果 体检发现 ,患者双上肢少拇指、食指和中指 ,缺桡侧手掌并双下肢足裂畸形。病因研究提示 ,P6 3基因第 5~ 8外显子 PCR扩增片段大小分别为 2 84 bp、2 5 9bp、2 4 5 bp和 2 5 9bp。患者与正常对照的扩增片段大小一致。但将患者扩增的片段 DNA序列分别与正常对照组以及人类基因库P6 3基因 DNA序列进行比较时则发现于 P6 3基因第 5外显子的第 6 6 5位碱基对出现突变 ,即由 G突变为A。结论 先天性少指缺掌并足裂家系患者系由 P6 3基因第 5外显子基因组的第 6 6 5位碱基对突变所致。 展开更多
关键词 少指缺掌 足裂 畸形 家系 P63基因突变
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少指(趾)畸形一家系的调查分析
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作者 胡周军 《中国医师杂志》 CAS 2001年第1期35-35,共1页
关键词 医学遗传学 畸形 少指畸形 调查
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小鼠短指/缺指畸形肢体cDNA消减文库的构建 被引量:1
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作者 陈蓉芳 张天宝 +2 位作者 印木泉 朱江波 郭苗莉 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2003年第4期281-285,共5页
目的 为筛选、克隆小鼠短指 /缺指畸形肢体的特异表达基因 ,构建了GD18小鼠畸形肢体 (短指 /缺指 )与正常肢体的差异表达的cDNA消减文库。方法 应用抑制消减杂交技术 (SSH ) ,结合PCRcDNA合成法 ,将从总RNA中合成的双链cDNA ,酶切成... 目的 为筛选、克隆小鼠短指 /缺指畸形肢体的特异表达基因 ,构建了GD18小鼠畸形肢体 (短指 /缺指 )与正常肢体的差异表达的cDNA消减文库。方法 应用抑制消减杂交技术 (SSH ) ,结合PCRcDNA合成法 ,将从总RNA中合成的双链cDNA ,酶切成平均大小为 4 0 0~ 6 0 0bp的片段 ,经接头连接 ,两次消减杂交和两次抑制性PCR后 ,将产物与T/A载体连接构建cDNA消减文库 ,并转染大肠杆菌进行文库扩增 ,菌液PCR筛选有插入片段的SSH克隆。结果 成功地构建了GD18小鼠畸形肢体(短指 /缺指 )差异表达的cDNA消减文库 ,从中挑取2 75个克隆进行菌液PCR分析 ,结果显示其中 2 5 5均得到 2 0 0~ 6 0 0bp插入片段。结论 SSH与PCR合成双链cDNA ,是一种自微量总RNA中构建高特异性的差异表达cDNA消减文库的有效方法。消减文库的构建 ,有助于筛选、克隆小鼠短指 展开更多
关键词 少指 基因表达 基因文库
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论陈云关于工业体制改革思想及其现实意义
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作者 张明 《经济研究参考》 1996年第H8期7-13,共7页
陈云同志是中国社会主义建设的开创者和奠基人之一,他的社会主义经济建设思想有深远意义。本文仅就陈云的工业体制改革思想及其现实意义作一探讨。
关键词 工业体制改革 陈云 工业管理体制 国有企业 现实意义 社会主义经济建设思想 经济体制改革 自主权 我国工业 少指
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专业银行向市场经济转换的操作方法
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作者 胡龙生 《江西社会科学》 CSSCI 1992年第6期152-152,共1页
一、国家金融宏观控制应由直接调控向间接调控转换,由用行政手段调控向用经济手段调控转换。中央银行要尽可能减少指令性计划,使专业银行有一个自主经营的宽松环境,以适应社会主义市场经济的需要。 二、要尽快制订和颁布实施《银行法》... 一、国家金融宏观控制应由直接调控向间接调控转换,由用行政手段调控向用经济手段调控转换。中央银行要尽可能减少指令性计划,使专业银行有一个自主经营的宽松环境,以适应社会主义市场经济的需要。 二、要尽快制订和颁布实施《银行法》,以法治行,这既能保护专业银行合法经营权益不受侵犯、抵制行政干预。 展开更多
关键词 专业银行 市场经济转换 操作方法 金融宏观控制 合法经营权 政策性贷款 自主经营 基层行 企业化改革 少指
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进一步改革我省计划体制的几点意见
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作者 陈志杰 《青海社会科学》 1987年第3期27-30,共4页
计划体制改革是整个经济体制改革的主要内容,进一步搞好计划体制改革,使之迅速转移到发展商品经济的轨道上来,保证青海经济的稳定发展,将是今后较长时期内我省计划工作的重要任务。现就计划体制改革的问题,谈一些粗浅的意见。 一、我省... 计划体制改革是整个经济体制改革的主要内容,进一步搞好计划体制改革,使之迅速转移到发展商品经济的轨道上来,保证青海经济的稳定发展,将是今后较长时期内我省计划工作的重要任务。现就计划体制改革的问题,谈一些粗浅的意见。 一、我省计划体制改革的情况 几年来,随着经济体制改革的不断深入,计划体制改革方面也做了很多工作,如减少了一些指令性计划指标,注意了中长期经济发展的研究,增加了经济效益、国民收入、综合财政计划等内容。但总的看来,还属起步阶段,直到一九八四年下半年,国务院批转了国家计委《关于改进计划体制的若干暂行规定》以后,才开始进入了实质性的改革阶段。两年来,主要抓了以下几方面的工作: 展开更多
关键词 计划体制 几点意见 青海经济 导性计划 宏观管理 生产资料市场 计划工作 计划管理 少指 发展商品经济
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三、为什么说计划和市场都是经济手段?
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《内蒙古宣传》 1992年第13期5-7,共3页
关键词 市场调节 经济手段 计划调节 收音机 调节方式 导性计划 少指 资本主义 社会主义
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Correlates of subjectively and objectively measured physical activity in young adolescents 被引量:2
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作者 Kelly Kavanaugh Justin B. Moore +1 位作者 Leisha Johnson Hibbett Andrew T. Kaczynski 《Journal of Sport and Health Science》 SCIE 2015年第3期222-227,共6页
Background: Many studies examining individual-level correlates in youth utilize self-report rather than objective measures of physical activity (PA). This utilization of self-report may result in associations that ... Background: Many studies examining individual-level correlates in youth utilize self-report rather than objective measures of physical activity (PA). This utilization of self-report may result in associations that are not present when examining objectively measured PA. The present study investigates the relationship between hypothesized correlates of PA with objectively and subjectively measured PA. Methods: Participating children (n 232, 101 males, mean age - 12.3 years) provided a minimum of four monitored days of PA (via accelerometer) and completed a survey assessing moderate-to-vigorous physical activity (MVPA), sport competence, appearance, enjoyment, and self-efficacy. Height and weight were measured and body mass index (BMI) was calculated. Results: Hierarchical regression models controlling for sex, race, and BMI Z-score showed that only sex and BMI Z-score were significant correlates of objective MVPA while only sex was a significant correlate of objective total PA. However, in a separate model examining the relationship with subjective MVPA, enjoyment of PA and self-efficacy for PA were the only significant correlates of self-reported PA. Conclusion: Measuring MVPA via self-report versus accelerometry produces considerably different results in a sample of young adolescents. Future studies should use caution when selecting outcome measures if the intent is to identify modifiable correlates of MVPA in youth. 展开更多
关键词 ACCELEROMETRY ENJOYMENT SELF-EFFICACY YOUTH
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Effects of water-current speed on hematological,biochemical and immune parameters in juvenile tinfoil barb,Barbonymus schwanenfeldii(Bleeker,1854) 被引量:2
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作者 朱志明 宋波澜 +1 位作者 林小涛 许忠能 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2016年第1期118-124,共7页
This study examines the effect of water-current speed on hematological,biochemical and immune parameters in juvenile tinfoil barb(B arbonymus schwanenfeldii). Blood samples were taken on days 1,23 and 45 from control ... This study examines the effect of water-current speed on hematological,biochemical and immune parameters in juvenile tinfoil barb(B arbonymus schwanenfeldii). Blood samples were taken on days 1,23 and 45 from control fish and from two training groups maintained at current speeds of 0.06 bl/s(body length per second),0.66 bl/s,and 1.92 bl/s,respectively. Significantly increased red-blood-cell counts and hematocrit were observed in the post-training groups on days 23 and 45. Significantly increased hemoglobin concentrations were also observed in the 1.92 bl/s group on days 23 and 45. In contrast,values of mean corpuscular volume were significantly lower in the 1.92 bl/s group than in the other groups on day 45. Nitroblue-tetrazolium-positive cells and lysozyme and superoxidase dismutase activities in the plasma increased significantly with increasing training intensity on days 23 and 45. Antibacterial activities were significantly increased in the trained groups compared with the control group on day 23; significantly elevated alkaline phosphatase activity was observed in the 1.92 bl/s groups on day 45. Therefore,training intensities of 0.66 and 1.92 bl/s enhanced the blood oxygen-carrying capability and plasma immune parameters of juvenile tinfoil barbs. 展开更多
关键词 Barbonymus schwanenfeldii sustained training blood oxygen-carrying capability immuneparameters
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Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury 被引量:8
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作者 黄伟 曹亮 +3 位作者 叶振江 林龙山 陈全震 窦硕增 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2012年第4期569-579,共11页
To understand mercury (Hg) toxicity in marine fish, we measured Hg accumulation in juvenile Japanese flounder (Paralichthys olivaceus) and assessed the effects on growth and antioxidant responses. After Hg exposu... To understand mercury (Hg) toxicity in marine fish, we measured Hg accumulation in juvenile Japanese flounder (Paralichthys olivaceus) and assessed the effects on growth and antioxidant responses. After Hg exposure (control, 5, 40, and 160 gg/L Hg) for 28 d, fish growth was significantly reduced. The accumulation of Hg in fish was dose-dependent and tissue-specific, with the maximum accumulation in kidney and liver, followed by gills, hone, and muscle. Different antioxidants responded differently to Hg exposure to cope with the induction of lipid peroxidation (LPO), which was also tissue-specific and dose- dependent. As Hg concentration increased, superoxide dismutase (SOD) and catalase (CAT) activities increased significantly, whereas glutathione S-transferase (GST) activity and glutathione (GSH) levels decreased significantly in the gills. SOD and glutathione peroxidase (GPx) activities and the GSH level increased significantly in the liver. SOD activity and GSH levels increased significantly, but CAT activity decreased significantly with an increase in Hg concentration in the kidney. LPO was induced significantly by elevated Hg in the gills and kidney but was least affected in the liver. Therefore, oxidative stress biomarkers in gills were more sensitive than those in the liver and kidney to Hg exposure. Thus, the gills have potential as bioindicators for evaluating Hg toxicity in juvenile flounder. 展开更多
关键词 mercury (Hg) ANTIOXIDANTS lipid peroxidation bioaccumulation of metal
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The association of various social capital indicators and physical activity participation among Turkish adolescents
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作者 Günay Y1ld1zer Emre Bilgin +2 位作者 Ezel Nur Korur Dario Novak GIyasettin Demirhan 《Journal of Sport and Health Science》 SCIE 2018年第1期27-33,共7页
Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations i... Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations in Turkey. The role of the social environment and social factors on PAP is being increasingly recognized. Although social capital(SC) indicators have been examined in high-income countries, there are few studies on developing countries. The aim of this study was to examine the relationship between SC indicators and PAP among Turkish adolescents.Methods: A survey was conducted among 19 high schools in 4 different cities in Turkey in 2016. A total of 506 female and 729 male high school students participated in this study. The dependent variable was overall PAP, which was measured using the short form of the International Physical Activity Questionnaire. The independent variables included self-perceived family, neighborhood, and school SC. Self-rated health and obesity status, measured by body mass index, were other study covariates in multiple binary logistic regression models. Chi-square tests were used to assess the differences between genders.Results: PAP levels were significantly different between males and females. A higher percentage of males reported PAP(77.4%) compared to females(51.0%). Among males, teacher–student interpersonal trust and informal social control were inversely associated with PAP, while high students interpersonal trust was positively associated with increased odds of PAP. For females, students interpersonal trust was inversely associated with PAP.Conclusion: Various SC indicators are associated with PAP for males and females. These associations are different from findings of studies conducted in developed countries. Therefore, health-promotion interventions and policies should consider gender and different social agents on the social and cultural background to improve PAP among Turkish adolescents. 展开更多
关键词 Adolescents Family NEIGHBORHOOD Physical activity Public health SCHOOL Social capital
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