利用单一的客观评估方法并不能有效揭示预报误差来源。利用逐小时5 km格点融合降水产品,本研究使用了多种客观评估方法综合评估了南京大学2016年夏季汛期试验4 km与12 km WRF模式。整体上,两种分辨率都能成功地预报主雨带,4 km WRF在午...利用单一的客观评估方法并不能有效揭示预报误差来源。利用逐小时5 km格点融合降水产品,本研究使用了多种客观评估方法综合评估了南京大学2016年夏季汛期试验4 km与12 km WRF模式。整体上,两种分辨率都能成功地预报主雨带,4 km WRF在午后对流及复杂地形预报上更优。比较了各类客观评估方法,邻域法显示4 km WRF预报准确性更高,但对于强降水(≥13 mm·(6 h)^(-1)),两种模式预报的空间误差都较大。尺度分离法显示,对于小尺度系统,4 km WRF能较好再现对流但存在较大位置误差,而12 km WRF则漏报。MODE法(Method for Object-based Diagnostic Evaluation)显示4 km WRF在对象强度预报上更接近观测,但强度和范围偏大,导致华南偏强,而范围偏小造成江淮偏弱,12 km WRF低估主要是漏报。不同评估方法能清晰展示4 km WRF和12 km WRF预报误差的差异,为后续模式改进提供了重要参考。展开更多
The salt-gradient operation mode used in ion-exchange simulated moving bed chromatography (SMBC) can improve the efficiency of protein separations. A detailed model that takes into account any kind of adsorption/ion-e...The salt-gradient operation mode used in ion-exchange simulated moving bed chromatography (SMBC) can improve the efficiency of protein separations. A detailed model that takes into account any kind of adsorption/ion-exchange equilibrium, salt gradient, size exclusion, mass transfer resistance, and port periodic switching mechanism, was developed to simulate the complex dynamics. The model predictions were verified by the experimental data on upward and downward gradients for protein separations reported in the literature. All design and operating parameters (number, configuration, length and diameter of columns, particle size, switching period, flow rates of feed, raffinate, desorbent and extract, protein concentrations in feed, different salt concentrations in desorbent and feed) can be chosen correctly by numerical simulation. This model can facilitate the design, operation, optimization, control and scale-up of salt-gradient ion-exchange SMBC for protein separations.展开更多
文摘利用单一的客观评估方法并不能有效揭示预报误差来源。利用逐小时5 km格点融合降水产品,本研究使用了多种客观评估方法综合评估了南京大学2016年夏季汛期试验4 km与12 km WRF模式。整体上,两种分辨率都能成功地预报主雨带,4 km WRF在午后对流及复杂地形预报上更优。比较了各类客观评估方法,邻域法显示4 km WRF预报准确性更高,但对于强降水(≥13 mm·(6 h)^(-1)),两种模式预报的空间误差都较大。尺度分离法显示,对于小尺度系统,4 km WRF能较好再现对流但存在较大位置误差,而12 km WRF则漏报。MODE法(Method for Object-based Diagnostic Evaluation)显示4 km WRF在对象强度预报上更接近观测,但强度和范围偏大,导致华南偏强,而范围偏小造成江淮偏弱,12 km WRF低估主要是漏报。不同评估方法能清晰展示4 km WRF和12 km WRF预报误差的差异,为后续模式改进提供了重要参考。
文摘The salt-gradient operation mode used in ion-exchange simulated moving bed chromatography (SMBC) can improve the efficiency of protein separations. A detailed model that takes into account any kind of adsorption/ion-exchange equilibrium, salt gradient, size exclusion, mass transfer resistance, and port periodic switching mechanism, was developed to simulate the complex dynamics. The model predictions were verified by the experimental data on upward and downward gradients for protein separations reported in the literature. All design and operating parameters (number, configuration, length and diameter of columns, particle size, switching period, flow rates of feed, raffinate, desorbent and extract, protein concentrations in feed, different salt concentrations in desorbent and feed) can be chosen correctly by numerical simulation. This model can facilitate the design, operation, optimization, control and scale-up of salt-gradient ion-exchange SMBC for protein separations.
