目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/...目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等结果;对单纯2型糖尿病组(T2DM) 34例2型糖尿病性视网膜病变组(DR) 64例变量行差异性分析;logistic回归分析筛选DR高危因素并绘制受试者工作特征曲线(ROC曲线)。结果:与T2DM组比较,DR组病程、血尿酸(SUA)、UHR、甘油三酯(TG)、TG/HDL-C水平升高(p pp p p p Objective: to investigate the correlation between blood uric acid/high-density lipoprotein cholesterol ratio (UHR) and diabetic retinopathy (DR). Methods: A total of 98 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology of Beihua University Hospital from March 2023 to March 2024 were selected as the study subjects. Clinical data and biochemical results were collected, and the results of BMI, UHR, and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) were calculated;for the 34 cases of type 2 diabetes mellitus in the type 2 diabetes mellitus group (T2DM) alone and the 64 cases in the diabetic retinopathy group (DR), the differences in variables were analyzed. Retinopathy group (DR) 64 cases were analyzed;logistic regression analysis was performed to screen the risk factors of DR and to draw the working characteristic curve (ROC curve) of the subjects. Results: Compared with the T2DM group, the DR group had increased disease duration, blood uric acid (SUA), UHR, triglyceride (TG), and TG/HDL-C levels (p p p p p p < 0.05). Conclusion: UHR, SUA, TG, and TG/HDL-C are all risk factors for the development of DR, with UHR having the greatest predictive value for the development of DR.展开更多
目的探讨骨转换与老年女性髋部脆性骨折(fragile hip fracture,HF)风险及与高密度脂蛋白胆固醇(HDLc)的相关性。方法选取2021年1月至2022年12月年龄≥60岁女性住院骨质疏松症患者共661例,分为无骨折组(A组)266例和HF组(B组)395例。检测...目的探讨骨转换与老年女性髋部脆性骨折(fragile hip fracture,HF)风险及与高密度脂蛋白胆固醇(HDLc)的相关性。方法选取2021年1月至2022年12月年龄≥60岁女性住院骨质疏松症患者共661例,分为无骨折组(A组)266例和HF组(B组)395例。检测总胆固醇(Tch)、甘油三酯(TG)、HDLc、低密度脂蛋白胆固醇(LDLc)、骨钙素N段中分子片段(N-MID OC)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、总蛋白(TP)、白蛋白(Alb)、钙(Ca)、磷(P)、镁(Mg)、尿素(Urea)、肌酐(Cr)、胱抑素C(Cys-C)、肾小球滤过率(eGFR)、骨形成率(MoMF)、骨吸收率(MoMR)及骨转化率(MoT)。结果(1)HF组TP[118(108,128)vs 124(114,131)]、Alb[38.4±3.7 vs 40.0±4.3]、HDLc[1.51(1.24,1.71)vs 1.54(1.37,1.73)]、Ca[2.21±0.12 vs 2.29±0.12]、P[1.03±0.16 vs 1.08±0.17]含量较无骨折组降低,年龄[76(68,83)vs 73(67,78)]、β-CTX[0.57(0.40,0.77)vs 0.34(0.19,0.56)]、MoMR[1.84(1.30,2.51)vs 1.09(0.61,1.83)]及MoT[2.16(1.56,2.85)vs 1.56(1.09,2.38)]较无骨折组增加,差异有统计学意义(P<0.05)。N-MID OC、MoMF、Urea、Cr、Cys-C、eGFR、Tch、TG、LDLc及Mg差异无统计学意义(P>0.05)。(2)老年女性HF与HDLc、TP、ALB、Ca、P、Mg呈负相关(r=-0.09、-0.26、-0.16、-0.28、-0.12、-0.03,P<0.05),与年龄、β-CTX、MoMR、MoT呈正相关(r=0.17、0.36、0.36、0.26,P<0.05),与N-MID OC、MoMF、Urea、Cr、Cys-C、eGFR、Tch、TG、LDLc无相关性(P>0.05)。(3)年龄、MoT、TP、Ca、P为老年女性HF的风险因素,OR分别为1.03(95%CI:1.01~1.06)、1.75(95%CI:1.44~2.12)、0.96(95%CI:0.92~0.99)、0.06(95%CI:0.01~0.37)、0.18(95%CI:0.06~0.6),P<0.05。(4)HDLc与骨转化间存在“U”型关系,P<0.01,其切点为1.692 mmol/L。结论高骨转换是老年女性HF的危险因素,其骨转化率与HDLc存在U型相关。展开更多
文摘目的:探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与糖尿病性视网膜病变(DR)的相关性。方法:选择2023年3月~2024年3月于北华大学附属医院内分泌科住院的2型糖尿病患者共98例作为研究对象,收集临床资料及生化结果,计算BMI、UHR、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)等结果;对单纯2型糖尿病组(T2DM) 34例2型糖尿病性视网膜病变组(DR) 64例变量行差异性分析;logistic回归分析筛选DR高危因素并绘制受试者工作特征曲线(ROC曲线)。结果:与T2DM组比较,DR组病程、血尿酸(SUA)、UHR、甘油三酯(TG)、TG/HDL-C水平升高(p pp p p p Objective: to investigate the correlation between blood uric acid/high-density lipoprotein cholesterol ratio (UHR) and diabetic retinopathy (DR). Methods: A total of 98 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology of Beihua University Hospital from March 2023 to March 2024 were selected as the study subjects. Clinical data and biochemical results were collected, and the results of BMI, UHR, and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) were calculated;for the 34 cases of type 2 diabetes mellitus in the type 2 diabetes mellitus group (T2DM) alone and the 64 cases in the diabetic retinopathy group (DR), the differences in variables were analyzed. Retinopathy group (DR) 64 cases were analyzed;logistic regression analysis was performed to screen the risk factors of DR and to draw the working characteristic curve (ROC curve) of the subjects. Results: Compared with the T2DM group, the DR group had increased disease duration, blood uric acid (SUA), UHR, triglyceride (TG), and TG/HDL-C levels (p p p p p p < 0.05). Conclusion: UHR, SUA, TG, and TG/HDL-C are all risk factors for the development of DR, with UHR having the greatest predictive value for the development of DR.
文摘目的探讨骨转换与老年女性髋部脆性骨折(fragile hip fracture,HF)风险及与高密度脂蛋白胆固醇(HDLc)的相关性。方法选取2021年1月至2022年12月年龄≥60岁女性住院骨质疏松症患者共661例,分为无骨折组(A组)266例和HF组(B组)395例。检测总胆固醇(Tch)、甘油三酯(TG)、HDLc、低密度脂蛋白胆固醇(LDLc)、骨钙素N段中分子片段(N-MID OC)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、总蛋白(TP)、白蛋白(Alb)、钙(Ca)、磷(P)、镁(Mg)、尿素(Urea)、肌酐(Cr)、胱抑素C(Cys-C)、肾小球滤过率(eGFR)、骨形成率(MoMF)、骨吸收率(MoMR)及骨转化率(MoT)。结果(1)HF组TP[118(108,128)vs 124(114,131)]、Alb[38.4±3.7 vs 40.0±4.3]、HDLc[1.51(1.24,1.71)vs 1.54(1.37,1.73)]、Ca[2.21±0.12 vs 2.29±0.12]、P[1.03±0.16 vs 1.08±0.17]含量较无骨折组降低,年龄[76(68,83)vs 73(67,78)]、β-CTX[0.57(0.40,0.77)vs 0.34(0.19,0.56)]、MoMR[1.84(1.30,2.51)vs 1.09(0.61,1.83)]及MoT[2.16(1.56,2.85)vs 1.56(1.09,2.38)]较无骨折组增加,差异有统计学意义(P<0.05)。N-MID OC、MoMF、Urea、Cr、Cys-C、eGFR、Tch、TG、LDLc及Mg差异无统计学意义(P>0.05)。(2)老年女性HF与HDLc、TP、ALB、Ca、P、Mg呈负相关(r=-0.09、-0.26、-0.16、-0.28、-0.12、-0.03,P<0.05),与年龄、β-CTX、MoMR、MoT呈正相关(r=0.17、0.36、0.36、0.26,P<0.05),与N-MID OC、MoMF、Urea、Cr、Cys-C、eGFR、Tch、TG、LDLc无相关性(P>0.05)。(3)年龄、MoT、TP、Ca、P为老年女性HF的风险因素,OR分别为1.03(95%CI:1.01~1.06)、1.75(95%CI:1.44~2.12)、0.96(95%CI:0.92~0.99)、0.06(95%CI:0.01~0.37)、0.18(95%CI:0.06~0.6),P<0.05。(4)HDLc与骨转化间存在“U”型关系,P<0.01,其切点为1.692 mmol/L。结论高骨转换是老年女性HF的危险因素,其骨转化率与HDLc存在U型相关。