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全脑放疗联合γ-刀局部加量治疗脑转移瘤的临床疗效 被引量:6
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作者 张倩 胡力宏 +2 位作者 宋旭旭 王顺 杨杰智 《医疗卫生装备》 CAS 2016年第7期87-89,100,共4页
目的:探讨肺癌脑转移瘤使用单纯全脑放疗与联合γ-刀局部加量放疗的临床疗效差异。方法:选择60名肺癌脑转移患者,随机分为A、B 2组,每组30人,A组接受全脑照射治疗,B组接受全脑照射治疗后行γ-刀局部加量治疗。对比2组患者颅内肿瘤缩小... 目的:探讨肺癌脑转移瘤使用单纯全脑放疗与联合γ-刀局部加量放疗的临床疗效差异。方法:选择60名肺癌脑转移患者,随机分为A、B 2组,每组30人,A组接受全脑照射治疗,B组接受全脑照射治疗后行γ-刀局部加量治疗。对比2组患者颅内肿瘤缩小程度、客观缓解率、总生存期。结果:A组患者颅内肿瘤缩小程度小于B组患者(P<0.05);A组患者客观缓解率小于B组患者(P<0.05);A组患者较B组患者总生存期短,且存在明显差异(P<0.05)。结论:全脑放疗可提高肺癌颅内转移患者总生存期,全脑放疗后对于颅内肿瘤进行局部γ-刀治疗可使颅内肿瘤明显缩小,且加量后患者总生存时间较非加量组长且存在明显统计学差异。 展开更多
关键词 脑转移瘤 全脑放疗 γ-刀局部加量 临床疗效
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全脑放疗与适形调强局部加量治疗乳腺癌脑转移疗效分析 被引量:3
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作者 司马义力.买买提尼牙孜 木克代斯.拜克提亚尔 +2 位作者 贺春钰 朱相露 木妮热.木沙江 《海南医学》 CAS 2016年第17期2851-2852,共2页
目的探讨乳腺癌脑转移患者采用全脑放疗与适形调强局部加量放疗联合治疗的临床疗效。方法回顾性分析我院乳腺放疗科2011年1月至2014年6月收治的68例乳腺癌脑转移患者的临床诊治资料,其中34例采用全脑放疗30 Gy后局部缩野照射者为观察组... 目的探讨乳腺癌脑转移患者采用全脑放疗与适形调强局部加量放疗联合治疗的临床疗效。方法回顾性分析我院乳腺放疗科2011年1月至2014年6月收治的68例乳腺癌脑转移患者的临床诊治资料,其中34例采用全脑放疗30 Gy后局部缩野照射者为观察组,34例全程局部缩野照射者为对照组,治疗2个周后。比较两组患者的临床疗效、1年生存率、治疗前后生活质量及不良反应。结果观察组病灶临床控制率为55.9%(19/34),明显高于对照组的26.5%(9/34),差异有统计学意义(P<0.05);观察组1年生存者23例(67.6%),明显高于对照组的10例(29.4%),差异有统计学意义(P<0.05);观察组和对照组患者治疗后的KPS评分分别为(89.9±6.3)分、(72.8±5.9)分,均比同组治疗前[(58.9±7.3)分、(59.7±6.9)分]明显提高(P<0.05),且观察组患者治疗后的KPS评分明显高于对照组,差异有统计学意义(P<0.05);观察组食欲下降率明显低于对照组[17.6%(6/34)vs 50.0%(17/34)],差异有统计学意义(P<0.05),但两组患者的恶心呕吐等不良反应率相当。结论应用全脑放疗与适形调强局部加量放疗联合治疗乳腺癌脑转移效果显著,且不良反应较小。 展开更多
关键词 全脑放疗 三维适形调强局部加量放疗 乳腺癌 脑转移 疗效
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全颅照射后局部加量联合化疗治疗乳腺癌脑转移的临床效果
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作者 秦付敏 张睿 《河南医学研究》 CAS 2019年第20期3698-3699,共2页
目的探讨全颅照射后局部加量联合化疗治疗乳腺癌脑转移的临床效果。方法选取2015年3月至2017年12月焦作市第二人民医院收治的134例乳腺癌脑转移患者,按照随机数表法将其分为对照组与观察组,每组67例。对照组接受全颅照射后局部加量放疗... 目的探讨全颅照射后局部加量联合化疗治疗乳腺癌脑转移的临床效果。方法选取2015年3月至2017年12月焦作市第二人民医院收治的134例乳腺癌脑转移患者,按照随机数表法将其分为对照组与观察组,每组67例。对照组接受全颅照射后局部加量放疗,观察组在对照组基础上接受联合多西他赛联合洛铂化疗。对比两组临床疗效、治疗前后生存质量[卡氏功能状态评分(KPS)]。结果两组客观有效率比较,差异无统计学意义(P>0.05)。观察组疾病控制率[86.57%(58/67)]高于对照组[71.64%(48/67)],差异有统计学意义(P<0.05)。治疗后,观察组KPS评分高于对照组,差异有统计学意义(P<0.001)。结论全颅照射后局部加量联合化疗可有效提高乳腺癌脑转移疾病控制率,且有利于改善患者生存质量。 展开更多
关键词 乳腺癌脑转移 全颅照射 局部加量 化疗
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Influences of nonassociated flow rules on three-dimensional seismic stability of loaded slopes 被引量:3
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作者 N.GANJIAN F.ASKARI O.FARZANEH 《Journal of Central South University》 SCIE EI CAS 2010年第3期603-611,共9页
The influences of soil dilatancy angle on three-dimensional (3D) seismic stability of locally-loaded slopes in nonassociated flow rule materials were investigated using a new rotational collapse mechanism and quasi-... The influences of soil dilatancy angle on three-dimensional (3D) seismic stability of locally-loaded slopes in nonassociated flow rule materials were investigated using a new rotational collapse mechanism and quasi-static coefficient concept. Extended Bishop method and Boussinesq theorem were employed to establish the stress distribution along the rupture surfaces that are required to obtain the rate of internal energy dissipation for the nonassociated flow rule materials in rotational collapse mechanisms. Good agreement was observed by comparing the current results with those obtained using the translational or rotational mechanisms and numerical finite difference method. The results indicate that the seismic stability of slopes reduces by decreasing the dilatancy angle for nonassociated flow rule materials. The amount of the mentioned decrease is more significant in the case of mild slopes in frictional soils. A nearly infinite slope under local loading, whether its critical failure surface is 2D or 3D, not only depends on the magnitude of the external load, but also depends on the dilataney angle of soil and the coefficient of seismic load. 展开更多
关键词 3D slope stability failure analysis nonassociated flow rule
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基于DWI及^(18)F-FDG PET-CT勾画胸段食管癌大体肿瘤体积变化与比较 被引量:1
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作者 李慧敏 李建彬 +4 位作者 李奉祥 张英杰 李彦康 郭延娈 徐亮 《中华放射肿瘤学杂志》 CSCD 北大核心 2021年第12期1238-1243,共6页
目的探讨基于食管癌原发肿瘤弥散加权像(DWI)高信号区域指导个体化局部加量放疗的可行性。方法对比32例胸段食管癌患者放疗前和放疗第15次时增强3DCT、18F-FDG PET-CT及增强MRI定位扫描图像,基于放疗前和放疗中3DCT、PET-CT及基于MRI的... 目的探讨基于食管癌原发肿瘤弥散加权像(DWI)高信号区域指导个体化局部加量放疗的可行性。方法对比32例胸段食管癌患者放疗前和放疗第15次时增强3DCT、18F-FDG PET-CT及增强MRI定位扫描图像,基于放疗前和放疗中3DCT、PET-CT及基于MRI的DWI与T2WI融合图像勾画食管癌大体肿瘤体积(GTV)并分别定义为GTV_(CTpre)和GTV_(CTdur)、GTV_(PETpre)和GTV_(PETdur)、GTV_(DWIpre)和GTV_(DWIdur),分别测量放疗前及放疗中标准摄取值(SUV)、代谢肿瘤体积(MTV)、病灶糖酵解总量(TLG)、表观弥散系数(ADC)并计算其变化。结果治疗前与治疗中基于PET-CT和DWI图像所勾画食管癌GTV体积及其变化与相应增强3DCT之间均呈正相关(均P<0.001);SUV、MTV、TLG、ADC差异均有统计学意义(均P<0.001);无论治疗前还是治疗中GTV的SUV与ADC、△SUV与△ADC均无相关性(均P>0.05);GTV_(PETpre)与GTV_(DWIpre)间适形指数(CI)明显高于GTV_(PETdur)与GTV_(DWIdur)间的CI(P<0.001);基于DWI的GTV最大径退缩率及体积退缩率均>基于PET者(24%∶14%,P=0.017;60%∶41%,P<0.001)。结论无论放疗前还是放疗中食管癌SUV与ADC值、△SUV与△ADC均无相关性;放疗中期基于PET-CT图像高FDG摄取区勾画的GTV与基于DWI高信号区勾画者空间位置差异明显,且后者GTV退缩率明显大于前者。因此,放疗中基于DWI高信号区的变化进行放疗后程食管癌局部加量照射的可行性并不明确。 展开更多
关键词 弥散权成像 体层摄影术 正电子发射-X线计算机 大体肿瘤体积 食管肿瘤/局部加量照射
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Momentum-space imaging spectroscopy for the study of nanophotonic materials 被引量:3
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作者 Yiwen Zhang Maoxiong Zhao +12 位作者 Jiajun Wang Wenzhe Liu Bo Wang Songting Hu Guopeng Lu Ang Chen Jing Cui Weiyi Zhang Chia Wei Hsu Xiaohan Liu Lei Shi Haiwei Yin Jian Zi 《Science Bulletin》 SCIE EI CSCD 2021年第8期824-838,M0004,共16页
The novel phenomena in nanophotonic materials, such as the angle-dependent reflection and negative refraction effect, are closely related to the photonic dispersions EepT. EepT describes the relation between energy E ... The novel phenomena in nanophotonic materials, such as the angle-dependent reflection and negative refraction effect, are closely related to the photonic dispersions EepT. EepT describes the relation between energy E and momentum p of photonic eigenmodes, and essentially determines the optical properties of materials. As EepT is defined in momentum space(k-space), the experimental method to detect the energy distribution, that is the spectrum, in a momentum-resolved manner is highly required. In this review, the momentum-space imaging spectroscopy(MSIS) system is presented, which can directly study the spectral information in momentum space. Using the MSIS system, the photonic dispersion can be captured in one shot with high energy and momentum resolution. From the experimental momentumresolved spectrum data, other key features of photonic eigenmodes, such as quality factors and polarization states, can also be extracted through the post-processing algorithm based on the coupled mode theory. In addition, the interference configurations of the MSIS system enable the measurement of coherence properties and phase information of nanophotonic materials, which is important for the study of light-matter interaction and beam shaping with nanostructures. The MSIS system can give the comprehensive information of nanophotonic materials, and is greatly useful for the study of novel photonic phenomena and the development of nanophotonic technologies. 展开更多
关键词 Momentum space imaging Nanophotonic material Photonic dispersion Photonic eigenmode Quality factor Polarization state
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Non-thermal radiation heating synthesis of nanomaterials
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作者 Guowei Xiong Jin Jia +4 位作者 Lili Zhao Xiaoyan Liu Xiaoli Zhang Hong Liu Weijia Zhou 《Science Bulletin》 SCIE EI CSCD 2021年第4期386-406,M0004,共22页
The nanoscale effect enables the unique magnetic,optical,thermal and electrical properties of nanostructured materials and has attracted extensive investigation for applications in catalysis,biomedicine,sensors,and en... The nanoscale effect enables the unique magnetic,optical,thermal and electrical properties of nanostructured materials and has attracted extensive investigation for applications in catalysis,biomedicine,sensors,and energy storage and conversion.The widely used synthesis methods,such as traditional hydrothermal reaction and calcination,are bulk heating processes based on thermal radiation.Differing from traditional heating methods,non-thermal radiation heating technique is a local heating mode.In this regard,this review summarizes various non-thermal radiation heating methods for synthesis of nanomaterials,including microwave heating,induction heating,Joule heating,laser heating and electron beam heating.The advantages and disadvantages of these non-thermal radiation heating methods for the synthesis of nanomaterials are compared and discussed.Finally,the future development and challenges of non-thermal radiation heating method for potential synthesis of nanomaterials are discussed. 展开更多
关键词 Synthesis of nanomaterials Microwave heating Induction heating Joule heating Laser heating
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