On 23 December 2015, China Food and Drug Administration （CFDA） promulgated the Technical Safety Standards for Cosmetics （TSSC）, which has been implemented on 1 December 2016. It has made a signifcant effect on cos...On 23 December 2015, China Food and Drug Administration （CFDA） promulgated the Technical Safety Standards for Cosmetics （TSSC）, which has been implemented on 1 December 2016. It has made a signifcant effect on cosmetics enterprises and attracted extensive attentions from the industry. In this paper, some hot issues about the TSSC are collected and responded by the experts and scholars.展开更多
Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Tra...Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Traditionally, safety evaluation of cosmetics uses animal tests. With the development of in vitro science and the 3R （Reduction, Replacement and Refinement） principle, three-dimensional reconstructed human epidermis （3D-RHE） models have been developed and widely applied in cosmetic safety evaluation. Reconstructed human skin models possess anatomy and metabolism biology similar to real human tissue. This paper reviews the current application of 3D-RHE models in the safety evaluation of skin irritation, eye irritation, phototoxicity and genotoxicity potential of cosmetic ingredients/formulas. The advantages and disadvantages of using skin models are also discussed, and comments and suggestions are given for its future development.展开更多
This paper introduced the development of Technical Safety Standards for Cosmetics(TSSC). It explained changes in TSSC in detail and put forward related suggestions for implementation.
文摘On 23 December 2015, China Food and Drug Administration （CFDA） promulgated the Technical Safety Standards for Cosmetics （TSSC）, which has been implemented on 1 December 2016. It has made a signifcant effect on cosmetics enterprises and attracted extensive attentions from the industry. In this paper, some hot issues about the TSSC are collected and responded by the experts and scholars.
文摘Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Traditionally, safety evaluation of cosmetics uses animal tests. With the development of in vitro science and the 3R （Reduction, Replacement and Refinement） principle, three-dimensional reconstructed human epidermis （3D-RHE） models have been developed and widely applied in cosmetic safety evaluation. Reconstructed human skin models possess anatomy and metabolism biology similar to real human tissue. This paper reviews the current application of 3D-RHE models in the safety evaluation of skin irritation, eye irritation, phototoxicity and genotoxicity potential of cosmetic ingredients/formulas. The advantages and disadvantages of using skin models are also discussed, and comments and suggestions are given for its future development.
文摘This paper introduced the development of Technical Safety Standards for Cosmetics(TSSC). It explained changes in TSSC in detail and put forward related suggestions for implementation.
