山皮条水提物急性毒性试验及镇痛抗炎药效研究

目的:考察山皮条水提物小鼠灌胃给药急性毒性和镇痛抗炎作用。方法:采用半数致死量(LD_(50))法测定山皮条水提物小鼠灌胃给药急性毒性反应;采用醋酸致小鼠扭体试验和二甲苯致小鼠耳肿胀试验分别观察山皮条水提物的镇痛、抗炎作用。结果:在本实验条件和所设计剂量范围内,山皮条水提物24 h内小鼠单次灌胃给药LD_(50)为15. 48 g/kg·bw (相当于生药量85. 05 g/kg·bw),95%可信区间为14. 07～16. 99 g/kg·bw (相当于生药量77. 31～93. 35 g/kg·bw);与模型对照组比较,山皮条水提物在3. 15 g/kg·bw、6. 30 g/kg·bw (相当于生药量17. 31 g/kg·bw、34·62 g/kg·bw)剂量下,能明显抑制醋酸所致小鼠扭体反应(P <0. 01),在6. 30 g/kg·bw (相当于生药量34. 62 g/kg·bw)剂量下能降低二甲苯所致的小鼠耳肿胀度(P <0. 01)。结论:山皮条水提物具有明显的抗炎、镇痛作用,但具有一定的毒性。

山皮条民间整理与应用

山皮条又名金雀花,为豆科植物,属四川木兰。多年生小灌木,喜生长在向阳山坡石灰岩地带。药用其根。味淡,性辛;有清热降火,消炎解毒,除恶疮的功能。山皮条原系苗族专治恶疮的家传草药。1964年笔者几经暗访得一标本,经临床应用疗效确实。多年来以山皮条为主,佐以其它药物主治急性乳腺炎、疮毒类疾病,疗效确实。兹整理介绍如下:

民间医药治验疑难杂症五则探讨

民间医药学是祖国灿烂医学中的瑰宝。千百年来,各民族在与疾病作斗争中积累了具有本民族特色的医药知识和丰富的治疗经验,即使在科学高度发展的今天,民间医药在广大城乡仍在为群众防病治病发挥着重要的作用。笔者在近20年的临床工作中,积极采集和运用民间医药,认真研究民间中草药和单方、验方、秘方,在临床上取得了较好的疗效。现将多年来自己运用民间医药治验疑难杂症五则收集整理,供同道们参考。

Optimization of Conditions for the Extraction of Melanin from Walnut Husk

[Objective] This study was conducted optimize the conditions for the ex- traction of melanin from walnut husk. [Method] Melanin was isolated from walnut husk through alkali extraction and acid precipitation, and the factors that may influ- ence the extraction efficiency： temperature, duration, NaOH concentration and solid- liquid ratio were set at different levels. [Result] The optimal conditions for the ex- traction of melanin from walhut husk were temperature of 80 ℃, extraction duration of 120 min, NaOH concentration of 70 mol/L, and solid-liquid ratio of 1：20. [Conclu- sion] The optimal conditions for the extraction of melanin from walnut husk deter- mined in the present study will provide references for the development and utiliza- tion of natural melanin.