There are four kinds of the most famous vinegars in China. Qingxu Very Mature Vinegar of Shanxi Province is number one. Three others are Zhenjiang Savory Vinegar of Jiangsu Province, Baoning Bran Vinegar of Sichuan Pr...There are four kinds of the most famous vinegars in China. Qingxu Very Mature Vinegar of Shanxi Province is number one. Three others are Zhenjiang Savory Vinegar of Jiangsu Province, Baoning Bran Vinegar of Sichuan Province and Yongchun Vinegar of Fujian Province展开更多
Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small...Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time.展开更多
Landslides not only cause property losses,but also kill and injure large numbers of people every year in the mountainous areas. These losses and casualties may be avoided to some extent by early warning systems for la...Landslides not only cause property losses,but also kill and injure large numbers of people every year in the mountainous areas. These losses and casualties may be avoided to some extent by early warning systems for landslides. In this paper, a realtime monitoring network and a computer-aided automatic early warning system(EWS) are presented with details of their design and an example of application in the Longjingwan landslide, Kaiyang County, Guizhou Province. Then, according to principle simple method of landslide prediction, the setting of alarm levels and the design of appropriate counter-measures are presented. A four-level early warning system(Zero, Outlook, Attention and Warning) has been adopted, and the velocity threshold was selected as the main warning threshold for the landslide occurrence, but expert judgment is included in the EWS to avoid false alarms. A case study shows the applicability and reliability for landslide risk management, and recommendations are presented for other similar projects.展开更多
During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand w...During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand was found. This phenomenon was initially confirmed to be due to seismic liquefaction. Many microscopic seismic relics,such as load structure,flow structure,cutoff plane and flotation of organic matter were found in the directional microscopic analysis of deformation. These discoveries and cognitions prove that there were two earthquake events taking place in the Western Zhou Dynasty-Late Spring and Autumn Period in this area. Above-mentioned works enrich and develop the research methods to identify prehistoric earthquake event in eastern China area to a certain extent.展开更多
文摘There are four kinds of the most famous vinegars in China. Qingxu Very Mature Vinegar of Shanxi Province is number one. Three others are Zhenjiang Savory Vinegar of Jiangsu Province, Baoning Bran Vinegar of Sichuan Province and Yongchun Vinegar of Fujian Province
基金Supported by a grant from the key Scientific Foundation of Shanxi Province (No. 051096-2)
文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time.
基金financially supported by the State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection (Chengdu University of Technology) (Grant No. SKLGP2013Z007)the National Natural Science Foundation of China (Grant No. 41302242)
文摘Landslides not only cause property losses,but also kill and injure large numbers of people every year in the mountainous areas. These losses and casualties may be avoided to some extent by early warning systems for landslides. In this paper, a realtime monitoring network and a computer-aided automatic early warning system(EWS) are presented with details of their design and an example of application in the Longjingwan landslide, Kaiyang County, Guizhou Province. Then, according to principle simple method of landslide prediction, the setting of alarm levels and the design of appropriate counter-measures are presented. A four-level early warning system(Zero, Outlook, Attention and Warning) has been adopted, and the velocity threshold was selected as the main warning threshold for the landslide occurrence, but expert judgment is included in the EWS to avoid false alarms. A case study shows the applicability and reliability for landslide risk management, and recommendations are presented for other similar projects.
基金This paper is a contribution to Scientific Research Special Project of the Earthquake Calling (200808064)Science and Technology Tackle Key Problem Plan Project of Anhui Province(08010302204)Natural Science Fund of Anhui Province(070415222),China
文摘During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand was found. This phenomenon was initially confirmed to be due to seismic liquefaction. Many microscopic seismic relics,such as load structure,flow structure,cutoff plane and flotation of organic matter were found in the directional microscopic analysis of deformation. These discoveries and cognitions prove that there were two earthquake events taking place in the Western Zhou Dynasty-Late Spring and Autumn Period in this area. Above-mentioned works enrich and develop the research methods to identify prehistoric earthquake event in eastern China area to a certain extent.
