Toosendanin (TSN), a triterpenoid derivative from Chinese traditional medicine, is a selective presynaptic blocker and an effective antibotulismic agent. Recently, its apoptosis-initiated effect and cytotoxicity in se...Toosendanin (TSN), a triterpenoid derivative from Chinese traditional medicine, is a selective presynaptic blocker and an effective antibotulismic agent. Recently, its apoptosis-initiated effect and cytotoxicity in several human cancer cell lines were observed. Since a transient increase in intracellular Ca^2+ concentration ([Ca^2+]i) triggers and facilitates展开更多
文摘Toosendanin (TSN), a triterpenoid derivative from Chinese traditional medicine, is a selective presynaptic blocker and an effective antibotulismic agent. Recently, its apoptosis-initiated effect and cytotoxicity in several human cancer cell lines were observed. Since a transient increase in intracellular Ca^2+ concentration ([Ca^2+]i) triggers and facilitates
