The Internet is becoming increasingly more valuable in the field ofarchitectural design so that what we conventionally called CAD might soon be changed to Internetaided design (iAD). In order to have a clear vision of...The Internet is becoming increasingly more valuable in the field ofarchitectural design so that what we conventionally called CAD might soon be changed to Internetaided design (iAD). In order to have a clear vision of what IAD will be or could be, we should firstexamine what is currently available. This research focuses on an investigation of selected Webvendors, which are typical and most influential in providing Internet related services for the AECindustry. By comparing and analyzing their functionality, services provided, business models,technology and financial situation, we have seen that Internet application in the AEC industry isstill in early stage, especially in the area of on-line engineering consulting for architects.展开更多
The changes of stress and strain around the shaft under the non-axial symmetrical loads during the excavation are analyzed with the finite element semi-analytical method based on the separated variable method. The cha...The changes of stress and strain around the shaft under the non-axial symmetrical loads during the excavation are analyzed with the finite element semi-analytical method based on the separated variable method. The change laws of deformation and stress of surrounding rocks are obtaied. Moreover, an optimum method of the design and construction of the shaft lining is de veloped. which presents a new train of thought of the design and costruction of the shaft and has important theoretical value and extensive application prospects.展开更多
While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with ...While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine residues.The electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent effect.Asymmetric chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural product.Additionally,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-azaelectrocyclization.Both labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging.展开更多
文摘The Internet is becoming increasingly more valuable in the field ofarchitectural design so that what we conventionally called CAD might soon be changed to Internetaided design (iAD). In order to have a clear vision of what IAD will be or could be, we should firstexamine what is currently available. This research focuses on an investigation of selected Webvendors, which are typical and most influential in providing Internet related services for the AECindustry. By comparing and analyzing their functionality, services provided, business models,technology and financial situation, we have seen that Internet application in the AEC industry isstill in early stage, especially in the area of on-line engineering consulting for architects.
文摘The changes of stress and strain around the shaft under the non-axial symmetrical loads during the excavation are analyzed with the finite element semi-analytical method based on the separated variable method. The change laws of deformation and stress of surrounding rocks are obtaied. Moreover, an optimum method of the design and construction of the shaft lining is de veloped. which presents a new train of thought of the design and costruction of the shaft and has important theoretical value and extensive application prospects.
基金supported by Grants-in-Aid for Scientific Research No.19681024 and 19651095 from the Japan Society for the Promotion of ScienceGrant-in-Aid for Science Research on Priority Areas 16073222 from the Ministry of Education,Culture,Sports,Science and Technology(MEXT)+2 种基金Molecular Imaging Research Program from MEXT,Matching Fund Subsidy for a Private University,Collaborative Development of Innovative Seeds from Japan Science and Technology Agency(JST)New Energy and Industrial Technology Development Organization(NEDO,project ID:07A01014a)a Research Grants from Yamada Science Foundation
文摘While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine residues.The electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent effect.Asymmetric chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural product.Additionally,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-azaelectrocyclization.Both labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging.
