Objectives define the boundaries of complex engineering system.It is a hard work to identify the specific objectives of a complex engineering system.The objectives system development needs a complicated process,from n...Objectives define the boundaries of complex engineering system.It is a hard work to identify the specific objectives of a complex engineering system.The objectives system development needs a complicated process,from nix to prototype,and to final definition.The total process will cover the following course:from chaos to well-ordered;from qualitativeness to combination of quantitativeness and qualitativenss,then from qualitativeness to quantitativeness(a recurrent process),expert experience and theoretical science,rationality and sensibility,synthesis analysis and meta-synthesis,routinization and non-routinization.Such process is explicit in phase development yet overlapped;mutually confined yet mutually independent;permeated conflicts yet pregnant in harmony.This article explores the complexity of Sutong Bridge's objectives development and the process of meta-synthesis in the Sutong Bridge engineering.展开更多
In the current economic situation, strengthening the contract management of the construction cost has a beautifully role. At the same time, according to construction project cost management, the scientific management ...In the current economic situation, strengthening the contract management of the construction cost has a beautifully role. At the same time, according to construction project cost management, the scientific management of the contract, can promote the reasonable and balanced investment cost allocation in the quality and safety and other aspects of the project, so that the construction project can obtain higher added value, and to further promote China＇ s economic construction and accelerate the pace of the city. This paper first briefly elaborates our construction project cost of the contract management on the present situation, and some problems are analyzed and discussed, and then puts forward some suggestions on the measures and countermeasures for cost management of construction engineering contract.展开更多
Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets...Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 （VEGFR2） inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. In this study, we established a high-profile compounds library and certificated a novel compound named N-（N-pyrrolidylacetyl）-9-（4-bromobenzyl）-l,3,4,9-tetrahydro-^-carboline （YF-452）, which remarkably inhibited the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells （HUVECs） with little toxicity invitro. Rat thoracic aorta ring assay indicated that YF-452 significantly blocked the formation ofmicrovascular exvivo. In addition, YF-452 inhibited angiogenesis in chick chorioallantoic membrane （CAM） and mouse corneal micropocket assays. Moreover, YF-452 remarkably suppressed tumor growth in xenografts mice model. Furthermore, investigation of molecular mechanism revealed that YF-452 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase （ERK）, focal adhesion kinase （FAK） and Src. These results indicate that YF-452 inhibits angiogenesis and may be a potential antiangiogenic drug candidate for cancer therapy.展开更多
基金National Scientific and Technology Supporting Program of 11th 5-Year Plan(No.2006BAG04B06)
文摘Objectives define the boundaries of complex engineering system.It is a hard work to identify the specific objectives of a complex engineering system.The objectives system development needs a complicated process,from nix to prototype,and to final definition.The total process will cover the following course:from chaos to well-ordered;from qualitativeness to combination of quantitativeness and qualitativenss,then from qualitativeness to quantitativeness(a recurrent process),expert experience and theoretical science,rationality and sensibility,synthesis analysis and meta-synthesis,routinization and non-routinization.Such process is explicit in phase development yet overlapped;mutually confined yet mutually independent;permeated conflicts yet pregnant in harmony.This article explores the complexity of Sutong Bridge's objectives development and the process of meta-synthesis in the Sutong Bridge engineering.
文摘In the current economic situation, strengthening the contract management of the construction cost has a beautifully role. At the same time, according to construction project cost management, the scientific management of the contract, can promote the reasonable and balanced investment cost allocation in the quality and safety and other aspects of the project, so that the construction project can obtain higher added value, and to further promote China＇ s economic construction and accelerate the pace of the city. This paper first briefly elaborates our construction project cost of the contract management on the present situation, and some problems are analyzed and discussed, and then puts forward some suggestions on the measures and countermeasures for cost management of construction engineering contract.
基金supported by Major State Basic Research Development Program of China(2015CB910400)National Natural Science Foundation of China(81272463,81472788,81330049,81673304)The Science and Technology Commission of Shanghai Municipality(15431902200)
文摘Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 （VEGFR2） inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. In this study, we established a high-profile compounds library and certificated a novel compound named N-（N-pyrrolidylacetyl）-9-（4-bromobenzyl）-l,3,4,9-tetrahydro-^-carboline （YF-452）, which remarkably inhibited the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells （HUVECs） with little toxicity invitro. Rat thoracic aorta ring assay indicated that YF-452 significantly blocked the formation ofmicrovascular exvivo. In addition, YF-452 inhibited angiogenesis in chick chorioallantoic membrane （CAM） and mouse corneal micropocket assays. Moreover, YF-452 remarkably suppressed tumor growth in xenografts mice model. Furthermore, investigation of molecular mechanism revealed that YF-452 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase （ERK）, focal adhesion kinase （FAK） and Src. These results indicate that YF-452 inhibits angiogenesis and may be a potential antiangiogenic drug candidate for cancer therapy.
